{"text_format":"1","workbook":"xlsx","n_sheets":8,"sheets":["Start","DNEL Calculation Animal Data","INI","Config","Information","DNEL Results","Scenarios","Language"],"not_rendered":{"charts":0,"images":2,"macros":1,"external_links":0,"defined_names":377,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Start","index":0,"n_rows":30,"n_cols":7,"rows_kept":30,"cut":false,"hidden":false,"merged":[[19,1,19,5],[25,4,25,9],[21,1,21,9],[24,1,24,9],[2,1,2,2],[12,1,12,9],[15,1,15,9],[20,1,20,9],[22,1,22,9],[5,1,5,6],[5,7,5,9],[14,1,14,9],[13,1,13,9],[16,1,16,3],[17,1,17,9],[18,1,18,4]]}
[]
[null,{"$f":"Start_LanguageTool","v":"Please select the langauge:"}]
[null,"English"]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"Start_Introduction","v":"Starting information"}]
[null,{"$f":"Start_DNELDescription","v":"The European Union (EU) REACh legislation requires manufacturers and importers to calculate Derived No-Effect Levels (DNELs) for substances produced in quantities above 10 tonnes/year. "}]
[null,{"$f":"Start_DNELDefinition","v":"REACh Annex I (1.0.1.) defines DNELs as levels of exposure to the substance above which humans should not be exposed. REACh Annex I (1.4.1.) requires the establishment of DNELs for all relevant exposure patterns, reflecting the likely routes, duration and frequency of exposure. If justified by the exposure scenarios, a single DNEL may be sufficient. However, taking into account the available information and the exposure scenarios in Section 9 of the Chemical Safety Report, it may be necessary to identify different DNELs for each relevant human population (e.g. workers, general population and, if necessary, sub-populations such as children or pregnant women) and for different routes of exposure (oral, dermal, inhalation). Please note that the REACh legislation only requires that DNELs be derived for the leading health effect of a given exposure pattern, i.e. of a specific combination of exposure duration, frequency, route and human population. The leading health effect is defined as the toxic effect that leads to the lowest DNEL for a particular exposure pattern."}]
[null,{"$f":"Start_DNELES","v":"The SECO-DNEL Tool has a modular design. Each module consists of a DNEL scenario. The DNEL scenario comprises a (derived) DNEL and a set of rules used to derive the DNEL. The adoption of these rules are to be based on a broad methodological consensus and be consistent with the rules as set out by ECHA (2012). The current version 1.0 of the SECO-DNEL tool includes the DNEL scenarios for the reproductive toxicity and all non-reprotoxic effects (local or systemic) that arise from repeated exposure to a substance for a particular time span. DNELs may be derived for both workers and the general population. In total, version 1.0 of the tool contains 18 different DNEL scenarios. For more details on the DNEL scenarios, please consult the User's Manual on the SECO-DNEL tool 1.0.\n"}]
[null,{"$f":"Start_SECODNEL","v":"The methodology used in this tool follows a clear procedure:\n1. Substance-specific information should be used to derive the DNEL wherever possible.\n2. If substance-specific information is not available, the default procedure shall be applied.\nThe default procedure follows the guidance rules developed by ECHA (2012). The SECO-DNEL tool does not support default procedures from other institutions. In all cases, the user of the tool is required to explain and justify any deviations from the rules as set out by ECHA (2012). Because of its modular set-up, the existing DNEL scenarios may be reassessed and revised, or new scenarios may be added to the tool. Therefore, the tool should be regularly consulted for updates. \n\nThe SECO-DNEL Tool is provided free of charge.\n"}]
[null,{"$f":"Start_Acknowledgement","v":"Acknowledgements"}]
[null,{"$f":"Start_DNELMethod","v":"We would like to thank the Federal Institute for Occupational Safety and Health (Dortmund, Germany) for technical discussions and advice on the development of the SECO-DNEL Tool and UBit Schweiz AG for their technical support."}]
[null,{"$f":"Start_Kontakt","v":"Contact:"}]
[null,"dnel-tool@seco.admin.ch"]
[null,{"$f":"Start_ECHAGuidance","v":"Reference: "}]
[null,"ECHA (2012):  \"Characterisation of dose [concentration]-response for human health R.8\" "]
[null,{"$f":"Start_DNELWhatToDo","v":"To start the tool, please press the «Start SECO-DNEL Tool 1.0» button."}]
[]
[null,"Disclaimer"]
[null,null,null,null,{"$f":"DisclaimerBund1","v":"This software was downloaded from the website of the Swiss Federal Administration. All legal conditions regarding the Swiss Federal Administration apply."}]
[null,null,null,null,"www.disclaimer.admin.ch"]
[]
[]
[null,null,null,null,{"$f":"Start_Author","v":"Author"},"Dr. Bojan Gasic",{"$f":"Start_FunktionSECO","v":"Section Chemicals and Occupational Health (SECO)"}]

{"sheet":"DNEL Calculation Animal Data","index":1,"n_rows":414,"n_cols":10,"rows_kept":414,"cut":false,"hidden":false,"merged":[[40,1,40,3],[163,2,163,4],[143,2,143,3],[145,2,145,3],[148,2,148,6],[153,2,153,6],[160,2,160,4],[146,2,146,3],[76,1,76,3],[101,1,101,3],[68,1,68,3],[80,1,80,3],[97,1,97,4],[79,1,79,3],[95,1,95,5],[99,1,99,4],[3,1,3,9],[18,1,18,8],[14,1,14,3],[12,1,12,9],[7,1,7,9],[8,1,8,9],[4,1,4,9],[5,1,5,9],[6,1,6,9],[13,1,13,9],[29,4,29,5],[34,1,34,3],[36,1,36,3],[74,4,74,5],[43,1,43,3],[62,1,62,4],[66,1,66,3],[31,1,31,9],[38,4,38,5],[36,4,36,5],[38,1,38,3],[58,1,58,3],[60,1,60,3],[60,4,60,5],[58,4,58,5],[45,1,45,9],[93,1,93,9],[72,1,72,9],[104,1,104,3],[595,7,595,9],[63,1,63,9],[64,1,64,3],[115,1,115,4],[589,7,589,9],[109,1,109,3],[111,1,111,4],[103,1,103,4],[107,1,107,4],[121,1,121,4],[113,1,113,3],[70,1,70,3],[140,2,140,9],[22,1,22,5],[43,4,43,5],[126,1,130,7],[117,1,117,9],[105,1,105,4],[68,4,68,5],[74,1,74,3],[125,1,125,7],[119,1,119,4],[29,1,29,3],[40,4,40,5],[34,4,34,5],[41,1,41,2],[41,4,41,5],[27,1,27,9],[56,1,56,9]]}
[]
[]
[]
[null,"SECO-DNEL tool 1.0 - Simple European Calculator Of DNEL "]
[null,{"$f":"Intro_GeneralWorkFlow","v":"General work-flow for DNEL calculation - threshold effects"}]
[null,{"$f":"Intro_Step1","v":"Step 1: Select the relevant dose descriptor for the endpoint concerned (e.g. NOAEL, LOAEL)."}]
[null,{"$f":"Intro_Step2","v":"Step 2: Modify, when necessary, the relevant dose descriptor per endpoint to the correct starting point."}]
[null,{"$f":"Intro_Step3","v":"Step 3: Apply, when necessary, assessment factors to the correct starting point."}]
[null,{"$f":"Intro_DNELResults","v":"Results: Endpoint-specific DNEL values."}]
[]
[]
[]
[null,{"$f":"Intro_RemarkMandatoryFields","v":"The white coloured cells require you to enter a value, and the yellow coloured cells offer a selection of options from which one must be selected."}]
[null,{"$f":"Intro_StartingInformationSubstancesStudy","v":"Initial details of the substance and toxicological studies  "}]
[null,{"$f":"Intro_ProductIdentifier","v":"Product identifier:"}]
[null,{"$f":"Intro_SubstanceName","v":"Substance name"},{"$f":"Intro_CAS","v":"CAS-Nr."},{"$f":"Intro_EC","v":"EC-Nr."}]
[]
[]
[null,{"$f":"Intro_PhysicalChemicalPropertiesTitle","v":"Please enter information on the physical-chemical properties of the substance:"}]
[null,{"$f":"Intro_PhysicalState","v":"Physical state"},{"$f":"Intro_Density","v":"Density [kg/m3]"},{"$f":"Intro_PureVapourPressure","v":"Pure vapour pressure [Pa]"},{"$f":"Intro_MoleFraction","v":"Typical concentration [%]"},{"$f":"Intro_LogKOW","v":"Log Kow"},{"$f":"Intro_MolarMass","v":"Molar mass [g/mol]"},{"$f":"Intro_Temperature","v":"Temperature [ºC]"},{"$f":"Intro_Pressure","v":"Pressure [hPa]"}]
[null,"Please select:",null,null,null,null,null,20,1013]
[]
[null,{"$f":"Intro_StudyGuidelinesTitle","v":"Please enter details on the leading health effect and the study guideline: "}]
[null,{"$f":"Intro_LeadingHealthEffect","v":"Leading health effects (e.g. kidney effects)"},{"$f":"Intro_StudyGuideline","v":"Study guideline (e.g. OECD TG 413)"},{"$f":"Intro_StudyDuration","v":"Study duration (e.g. 90 days)"},{"$f":"Intro_Species","v":"Species (e.g. rat)"},{"$f":"Intro_NumberofAnimals","v":"Number of animals per dose group"}]
[]
[]
[]
[null,{"$f":"Step1_SelectDoseDescriptorTitle","v":"Step 1: Please select the relevant dose descriptor for the toxicological endpoint concerned."}]
[]
[null,{"$f":"Step1_SelectToxikologicalEndpoint","v":"Please select toxicological endpoint:"},null,null,"Please select:"]
[]
[null,{"$f":"Step1_EC3","v":"Please enter the effect concentration (EC, %) :"}]
[null,"skin",null,"µg/cm2/day",null,"Converts units for the effect concentration (EC3) from [%] to µg/cm2/day"]
[]
[null,{"$f":"Step1_SkinSensNOAELLOAEL","v":"Please select if the LLNA EC3 dose descriptor shall be considered as a NOAEL or LOAEL for induction:"},null,null,"Please select:"]
[]
[null,{"$f":"Step2_SelectRelevantPopulation","v":"Please select the relevant population:"},null,null,"Please select:"]
[]
[null,{"$f":"Step1_SelectEffectType","v":"Please select effect type:"},null,null,"Please select:"]
[]
[null,{"$f":"Step1_SelectDoseDescriptor","v":"Please select a dose descriptor:"},null,null,"Please select:"]
[null,{"$f":"Step1_SelectDoseDescriptor","v":"Please select a dose descriptor:"},null,null,"Please select:"]
[]
[null,{"$f":"Step1_SelectAdministrationRoute","v":"Please select an administration route:"},null,null,"Please select:"]
[]
[null,{"$f":"Step1_EnterDoseDescriptorValueTItle","v":"Please enter a dose descriptor value for the relevant administration route and select the correct units:"}]
[]
[null,{"$f":"Step1_Expositionsroute","v":"Exposure route"},{"$f":"Step1_ExposureValue","v":"Value"},{"$f":"Step1_ExposureUnits","v":"Units"}]
[null,"Oral",null,"Please select:"]
[null,"Dermal",null,"Please select:"]
[null,{"$f":"Step1_Inhalation","v":"Inhalation"},null,"Please select:"]
[]
[]
[]
[]
[]
[null,{"$f":"Step2_ModifyStartingPointCorrectionTitle","v":"Step 2: Please modify the relevant dose descriptor per endpoint to the correct starting point."}]
[]
[null,{"$f":"Step2_SelectRelevantHumanExpRoute","v":"Please select the relevant human exposure route:"},null,null,"Please select:"]
[]
[null,{"$f":"Step2_SelectRelevantPopulation","v":"Please select the relevant population:"},null,null,"Please select:"]
[]
[null,{"$f":"Step2_Bioavailability","v":"Bioavailability "}]
[]
[null,{"$f":"Step2_BioavailabilityExperimentalAnimal","v":"Please account for the bioavailability of experimental animals:"},null,null,null,"[%]"]
[]
[null,{"$f":"Step2_BioavailabilityHuman","v":"Please account for the bioavailability of humans:"},null,null,null,"[%]"]
[]
[null,{"$f":"Step2_ExperimentalAnimal","v":"Please select the experimental animal:"},null,null,"Please select:"]
[]
[null,{"$f":"Step2_ConsumerExposureDuration","v":"Please set consumer exposure duration:"},null,null,null," [h]        [1-24 h]"]
[]
[null,{"$f":"Step2_DiffExposureConditions","v":"Differences experimental/human exposure conditions"}]
[]
[null,{"$f":"Step2_ConcentrationDosesDependent","v":"Please select whether the toxic effect is\n1. concentration-driven or 2. dose-dependent?"},null,null,"Please select:"]
[]
[null,{"$f":"Step2_ExperimentalExpsoureConditions","v":"Experimental exposure conditions:"},null,null,null,{"$f":"Step2_ExpHoursPerDay","v":"hours/day"},null,null,{"$f":"Step2_ExpDaysWeek","v":"days/week"}]
[]
[]
[null,{"$f":"Step2_Results","v":"Results"}]
[null,"Other effect - systemic"]
[null,{"$f":"Step2_ExposureRoute","v":"Exposure route"},"Human NOAEC",{"$f":"Step2_ExposureUnits","v":"Units"}]
[null,"Oral",{"$f":"IFERROR((CorrectedDoseDescriptorOral*VLOOKUP(rngOralUnitsFinal,iniMatrixOralFinal,2,FALSE)),0)","v":0},"Please select:"]
[null,"Dermal",{"$f":"CorrectedDoseDescriptorDermal*VLOOKUP(rngDermalUnitsFinal,iniMatrixDermalFinal,2,FALSE)","v":0},"Please select:"]
[null,"Dermal",{"$f":"CorrectedDoseDescriptorDermalOral*VLOOKUP(rngDermalOralUnitsFinal,iniMatrixDermalFinal,2,FALSE)","v":0},"Please select:"]
[null,"Dermal",{"$f":"CorrectedDoseDescriptorDermalInhalation*VLOOKUP(rngDermalInhalationUnitsFinal,iniMatrixDermalFinal,2,FALSE)","v":0},"Please select:"]
[null,{"$f":"Step2_Inhalation","v":"Inhalation"},{"$f":"IFERROR((CorrectedDoseDescriptorInhalation*VLOOKUP(rngInhalationUnitsFinal,iniMatrixInhalationFinal,2,FALSE)),0)","v":0},"Please select:"]
[null,"Inhalation:",null,"Dermal Dermal",null,"Oral Dermal",null,"Inhalation Dermal",null,"Oral"]
[null,null,null,"Bereich",{"$f":"VLOOKUP(rngDermalUnitsStart,iniMatrixDermalStart,2,FALSE)","v":{"$error":"#N/A"}},null,null,null,null,{"$f":"VLOOKUP(rngOralUnitsStart,iniMatrixOralDermalStart,2,FALSE)","v":{"$error":"#NAME?"}}]
[]
[null,{"$f":"SUM(DoseDescriptorOral,DoseDescriptorDermal,DoseDescriptorInhalation)","v":0},{"$f":"SUM(CorrDoseDescriptorInhalation, CorrDoseDescriptorDermal,CorrDoseDescriptorDermalOral,CorrDoseDescriptorDermalInhalation, CorrDoseDescriptorOral)","v":0},{"$f":"IF(DoseDescriptorOral>0, rngOralUnitsStart, IF(DoseDescriptorDermal>0,rngDermalUnitsStart,IF(DoseDescriptorInhalation,rngInhalationUnitsStart,\"\")))","v":""},{"$f":"IF(CorrectedDoseDescriptorOral>0,rngOralUnitsFinal,IF(CorrDoseDescriptorDermal>0,rngDermalUnitsFinal,IF(CorrDoseDescriptorDermalOral>0,rngDermalOralUnitsFinal,IF(CorrDoseDescriptorDermalInhalation>0,rngDermalInhalationUnitsFinal,IF(CorrDoseDescriptorInhalation>0,rngInhalationUnitsFinal,\"\")))))","v":""},"corr inh NOAEC: ","NOAEL - oral route: ","corr inh NOAEC = oral NOAEL x 1/sRVan x Diff. exp. cond. x (ABSoral,an/ABSinh,hu) x sRVhu/wRV"]
[null,"ABSoral,an/ABSinh,hu",0.5,0.38,"m3/kg bw/8 h",1.4,"worker-DNEL long-term for inhalation route-systemic-other effect: "]
[]
[null,{"$f":"Step3_SelectAFTitle","v":"Step 3: Please apply assessment factors to the correct starting point"}]
[]
[null,{"$f":"Step3_InterspeciesVariability","v":"Interspecies variability"}]
[]
[null,{"$f":"Step3_AllomtericScalingText","v":"Please enter an allometric scaling factor:"}]
[]
[null,{"$f":"Step3_InterspeciesVariabilityText","v":"Please account for remaining differences in interspecies variability:"}]
[]
[null,{"$f":"Step3_IntraspeciesVariabilityLang","v":"Intraspecies variability"}]
[]
[null,{"$f":"Step3_IntraspeciesVariabilityLangText","v":"Please account for intraspecies differences in the target population:"}]
[]
[null,{"$f":"Step3_DifferencesExposureDuration","v":"Differences in duration of exposure"}]
[]
[null,{"$f":"Step3_DifferencesExposureDurationText","v":"Please account for the differences in the experimental exposure duration and the duration of exposure for the population:"},null,null,null,null,null,null,null," "]
[]
[null,{"$f":"Step3_DoseResponse","v":"Issues related to dose-response"}]
[]
[null,{"$f":"Step3_DoseResponseText","v":"Please enter an assessment factor to account for dose-response uncertainties:"}]
[]
[null,{"$f":"Step3_Quality","v":"Quality of the whole database"}]
[]
[null,{"$f":"Step3_QualityText","v":"Please enter an assessment factor to compensate for the potential remaining uncertainties regarding the quality of the whole database :"}]
[]
[null,{"$f":"Step3_SkinSensText","v":"Skin sensitation specific assessment factors"}]
[]
[null,{"$f":"Step3_SkinSensMatrix","v":"Please apply an assessment factor for vehicle or matrix effect, e.g. matrix with penetration enhancing properties:"}]
[]
[null,{"$f":"Step3_SkinSensExposureConditions","v":"Please apply an assessment factor for different exposure conditions, e.g. to account for differences in skin integrity."}]
[]
[]
[]
[null,{"$f":"DNELResults_Comments","v":"Please explain and justify, if necessary, any deviation from the default approach (max. 1400 characters):"}]
[]
[]
[]
[]
[]
[]
[]
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[]
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[null,null,{"$f":"DNELResult_Title","v":"Results: Please calculate the DNEL by clicking on the «Run DNEL Tool» button"}]
[]
[]
[null,null,{"$f":"DNELResults_OverallAssessmentFactor","v":"Overall assessment factor"}]
[]
[null,null,{"$f":"DNELResult_LeadingHealthEffect","v":"Leading health effect"}]
[null,null,{"$f":"IF('DNEL Calculation Animal Data'!B25=0,\"\",'DNEL Calculation Animal Data'!B25)","v":""}]
[]
[null,null,{"$f":"DNELResult_WorkerLongterm","v":"worker-DNEL long term"}]
[null,null,{"$f":"Step1_Expositionsroute","v":"Exposure route"},{"$f":"DNELResult_Systemic","v":"Systemic "},{"$f":"DNELResult_Units","v":"Units"},{"$f":"DNELResult_Local","v":"Local"},{"$f":"DNELResult_Units","v":"Units"}]
[null,null,{"$f":"Step1_Oral","v":"Oral"}]
[null,null,{"$f":"Step1_Dermal","v":"Dermal"}]
[null,null,{"$f":"Step1_Inhalation","v":"Inhalation"}]
[null,null,{"$f":"DNELResult_GenPopLongTerm","v":"general population-DNEL long term"}]
[null,null,{"$f":"Step1_Expositionsroute","v":"Exposure route"},{"$f":"DNELResult_Systemic","v":"Systemic "},{"$f":"DNELResult_Units","v":"Units"},{"$f":"DNELResult_Local","v":"Local"},{"$f":"DNELResult_Units","v":"Units"}]
[null,null,{"$f":"Step1_Oral","v":"Oral"}]
[null,null,{"$f":"Step1_Dermal","v":"Dermal"}]
[null,null,{"$f":"Step1_Inhalation","v":"Inhalation"}]
[null,null,null,1.6456140350877195,"mg/m3"]
[]
[null,null,{"$f":"DNELResult_WorkerSkinSens","v":"Worker - skin sensitising effect"}]
[null,null,{"$f":"Step1_Expositionsroute","v":"Exposure route"},{"$f":"DNELResult_Value","v":"Value"},{"$f":"DNELResult_Units","v":"Units"}]
[null,null,{"$f":"Step1_Dermal","v":"Dermal"},null,"µg/cm2/day"]
[null,null,{"$f":"DNELResult_GenPopSkinSens","v":"General population - skin sensitising effect"}]
[null,null,{"$f":"Step1_Expositionsroute","v":"Exposure route"},{"$f":"DNELResult_Value","v":"Value"},{"$f":"DNELResult_Units","v":"Units"}]
[null,null,{"$f":"Step1_Dermal","v":"Dermal"},null,"µg/cm2/day"]
[]
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[null,null,"-","-","-"]
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[null,null,null,null,"mg/cm2/d"]

{"sheet":"INI","index":2,"n_rows":103,"n_cols":3,"rows_kept":103,"cut":false,"hidden":true,"merged":[]}
[]
[]
[]
[]
["3. Toxicological endpoint"]
["Please select:"]
["Reprotoxic effect"]
["Other effect"]
[]
["4. Effect type"]
["Please select:"]
["Systemic effects"]
["Local effects"]
["Administration route"]
["Please select:"]
["Oral"]
["Dermal"]
["Inhalation"]
["5. Dose descriptor units"]
["Oral","Please select:"]
[null,"mg/kg bw/d"]
[null,"ug/kg bw/d"]
[null,"ng/kg bw/d"]
["Dermal","Please select:"]
[null,"mg/kg bw/d","iniMatrixDermalMGKGD"]
[null,"ug/kg bw/d","iniMatrixDermalMGKGD"]
[null,"ng/kg bw/d","iniMatrixDermalMGKGD"]
[null,"mg/cm2/d","iniMatrixDermalMGCM2D"]
[null,"ug/cm2/d","iniMatrixDermalMGCM2D"]
[null,"ng/cm2/d","iniMatrixDermalMGCM2D"]
["Inhalation","Please select:"]
[null,"mg/m3"]
[null,"ug/m3"]
[null,"ng/m3"]
[null,"ppm"]
[null,"ppb"]
["6. Human dose descriptor units"]
["Oral","Please select:"]
[null,"mg/kg bw/d",1]
[null,"ug/kg bw/d",1000]
[null,"ng/kg bw/d",1000000]
["Dermal","Please select:"]
[null,"mg/kg bw/d",1]
[null,"ug/kg bw/d",1000]
[null,"ng/kg bw/d",1000000]
[null,"Please select:"]
[null,"mg/cm2/d",1]
[null,"ug/cm2/d",1000]
[null,"ng/cm2/d",1000000]
["Inhalation","Please select:"]
[null,"mg/m3",1]
[null,"ug/m3",1000]
[null,"ng/m3",1000000]
[null,"ppm",{"$f":"( ((8.31447 * (StandardTemperature+ 273.15) / StandardPressure))*10)/MolarMass","v":{"$error":"#DIV/0!"}}]
[null,"ppb",{"$f":"C54*1000","v":{"$error":"#DIV/0!"}}]
[]
["Dose descriptors"]
["Animal data"]
["Repeated-dose - systemic - reprotoxic effects"]
[null,"Please select:"]
[null,"NOAEL/C fertility"]
[null,"LOAEL/C fertility"]
[null,"NOAEL/C development"]
[null,"LOAEL/C development"]
[]
["Repeated-dose - systemic - other effects"]
[null,"Please select:"]
[null,"NOAEL/C"]
[null,"LOAEL/C"]
[]
["Skin sensitising effect"]
[null,"Please select:"]
[null,"EC3"]
[]
[]
["Step 2: Starting point correction"]
["Relevant population",null,"Please select:"]
[null,null,"worker"]
[null,null,"consumer"]
[null,null,"human via the environment"]
[]
["Human exposure route",null,"Please select:"]
[null,null,"oral"]
[null,null,"dermal"]
[null,null,"inhalation"]
["Experimental animal",null,"Please select:"]
[null,null,"rat"]
[null,null,"mouse"]
[null,null,"hamster"]
[null,null,"guinea pig"]
[null,null,"rabbit"]
[null,null,"monkey"]
[null,null,"dog"]
["Conc./dose driven",null,"Please select:"]
[null,null,"concentration-driven"]
[null,null,"dose-dependent"]
[]
[]
["Please select:"]
["gas"]
["liquid"]
["solid (non powder)"]
["solid (powder)"]

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[null,"Substance name and identification numbers: \nThe user may enter the trade name of the substance or alternatively the name of the substance in accordance with Article 18(2) of Regulation (EC) No 1272/2008 (CLP): \n1. if the substance is included in Part 3 of Annex VI (CLP), a name and an identification number as given therein (i.e. index number, EC number and/or CAS number);\n2. if the substance is not included in Part 3 of Annex VI (CLP), but appears in the classification and labelling inventory, a name and an identification number as given therein (i.e. index number, EC number and/or CAS number);\n3. if the substance is not included in Part 3 of Annex VI (CLP) nor in the classification and labelling inventory, the number provided by the CAS, together with the name set out in the nomenclature provided by the IUPAC, or the CAS number together with another international chemical name; or                                                                                                                                                                                                                          4. if the CAS number is not available, the name set out in the IUPAC Nomenclature or another international chemical name. ","Stoffname und Identifikationsnummer: \nEs kann der Handelsname des Stoffes angegeben werden. \nAlternativ kann der Stoff auch nach Artikel 18(2) 1272/2008 (CLP) bezeichnet werden: \n1. falls der Stoff in Anhang VI Teil 3 aufgeführt ist: Namen und Identifikationsnummer, wie dort verwendet,\n2. falls der Stoff nicht in Anhang VI Teil 3, jedoch im Einstufungs- und Kennzeichnungsverzeichnis aufgeführt ist: Namen und Identifikationsnummer, wie dort verwendet,\n3. falls der Stoff weder in Anhang VI Teil 3 noch im Einstufungs- und Kennzeichnungsverzeichnis aufgeführt ist: die vom Chemical Abstracts Service ausgegebene Nummer (= CAS-Nummer\u008d‘), zusammen mit der von der Internationalen Union für reine und angewandte Chemie (= ‚IUPAC-Nomenklatur‘) bestimmten Namen, oder die CAS-Nummer zusammen mit einer anderen internationalen chemischen Bezeichnung oder                                                                                                                                                                                                                     4. falls keine CAS-Nummer verfügbar ist: den in der IUPAC-Nomenklatur angegebenen Namen oder eine andere internationale chemische Bezeichnung.     ","Nom de la substance et numéros d’identification :\nL’utilisateur peut nommer la substance conformément à l’article 18(2) du Règlement (CE) n° 1272/2008 (CLP) :\n1. si la substance figure à l’annexe VI, partie 3 (CLP), un nom et un numéro d’identification tels qu’ils figurent dans cette annexe (c.-à-d. numéro index, numéro CE et/ou numéro CAS) ;\n2. si la substance ne figure pas à l’annexe VI, partie 3 (CLP), mais figure dans l’inventaire des classifications et des étiquetages, un nom et un numéro d’identification tels qu’ils figurent dans cet inventaire (c.-à-d. numéro index, numéro CE et/ou numéro CAS) ;\n3. si la substance ne figure ni à l’annexe VI, partie 3 (CLP), ni dans l’inventaire des classifications et des étiquetages, le numéro fourni par le CAS accompagné du nom figurant dans la nomenclature fournie par l’UICPA ou le numéro CAS accompagné d’autres noms chimiques internationaux ; ou\n4. si le numéro CAS n'est pas disponible, le nom figurant dans la nomenclature UICPA ou d’autres noms chimiques internationaux.\n","Nome della sostanza e numeri di identificazione\nL’utente può nominare la sostanza in conformità con l’articolo 18 capoverso 2 del Regolamento (CE) N° 1272/2008 (CAS):\nPer una sostanza l'identificatore del prodotto comprende almeno gli elementi seguenti:\n1. se la sostanza è compresa nell'allegato VI, parte 3, la denominazione e il numero di identificazione che vi figurano;\n2. se la sostanza non è inclusa nell'allegato VI, parte 3, ma figura nell'inventario delle classificazioni e delle etichettature, la denominazione e il numero di identificazione che vi figurano;\n3. se la sostanza non è inclusa nell'allegato VI, parte 3, né nell'inventario delle classificazioni e delle etichettature, il numero assegnato dal CAS («numero CAS») unitamente alla denominazione figurante nella nomenclatura dell'IUPAC («nomenclatura IUPAC») o il numero CAS unitamente a un'altra denominazione chimica internazionale o con altre denominazioni chimiche internazionali; o;\n4. se il numero CAS non esiste, la denominazione figurante nella nomenclatura IUPAC o un'altra denominazione chimica internazionale o altre denominazioni chimiche internazionali.\n"]
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[null,"Physical-chemical properties:\nPhysical state: The user may select four different states of matter: 1. gas, 2. liquid, 3. solid (non-powder) or 4. solid (powder). Definitions of physical states (gas, liquid, solid) can be found in section 1.0. of Annex I (CLP).                   \nDensity: The density (ρ) of a substance is defined as the quotient of the mass m and its volume V: ρ = m/V; SI units [kg/m3]\nPure vapour pressure of the substance: The pure vapour pressure of a substance is defined as the saturation pressure above a solid or a liquid substance at constant temperature (usually 20 or 25 ºC). At the thermodynamic equilibrium, the vapour pressure of a pure substance is a function of temperature only. The tool uses the standard temperature of 20 ºC.                                                                                                       \nTypical concentration of the substance: Please enter the typical concentration of the main substance. For example, a substance A contains three components: the main component B [90 %], an impurity C [4 %] and an additive D [6 %]. The typical concentration of 90 % of the main substance must be entered in the corresponding cell. \nMolar mass: The molar mass is defined as the mass [g] of the substance divided by its amount [mol]. The units are often expressed in [mg/mol] or [g/mol]. The tool uses the units of [g/mol] for the molar mass. The molar mass must be entered to calculate the default values for the dermal and inhalative absorption in step 2.                                                                                                                                                               \nn-octanol/water partition coefficient, log Kow: The n-octanol/water partition coefficient (Kow) is defined as the ratio of the equilibrium concentrations of a dissolved substance in a two-phase system consisting of the largely immiscible solvents n-octanol and water. The property is moderately temperature-dependent and typically measured at 25 °C. The log Kow must be entered to calculate the default values for the dermal and inhalative absorption in step 2.   \n                                                                                                                                                                                                           \nFor further information on physical-chemical properties, please consult the ECHA guidance document R.7a: Endpoint specific guidance.","Physikalisch-chemische Eigenschaften:\nAggregatzustand: Es können vier verschiedene physikalische Zustände der Materie ausgewählt werden: 1. Gas, 2. Flüssigkeit, 3. Feststoff (nicht Pulver) oder 4. Feststoff (Pulver). Definitionen dieser Aggregatzustände (d.h. Gas, Flüssigkeit, Feststoff) können im Anhang I Abschnitt 1.0 CLP gefunden werden.                   \nDichte: Die Dichte (ρ) eines Stoffes entspricht dem Quotient der Masse m und seines Volumens V: ρ = m/V; SI Einheit [kg/m3].\nReiner Dampfdruck eines Stoffes: Der reine Dampfdruck eines Stoffes ist definiert als der Sättigungsdampfdruck über einem Feststoff oder einer Flüssigkeit bei einer konstanten Temperatur (in der Regel 20 oder 25 ºC). Im thermodynamischen Gleichgewicht ist der Dampfdruck eines Stoffes eine Funktion der Temperatur. Im Tool wird die Standard-Temperatur von 20 ºC verwendet.                                                                                                   \nTypische Stoffkonzentration: Bitte geben Sie die typische Konzentration (in %) des Hauptbestandteils des Stoffes ein. Zum Beispiel: Ein Stoff A enthält den Hauptbestandteil B [90 %], eine Verunreinigung C [4 %] und einen Zusatzstoff D [6 %]. Es ist die typische Stoffkonzentration von 90 % des Hauptbestandteils B in die Zelle einzugeben.                                                                                                                                                                    \nMolare Masse: Die molare Masse eines Stoffes ist definiert als der Quotient der Masse eines Stoffes und seiner Stoffmenge M [mol]. Im Tool wird die Einheit [g/mol] für die molare Masse verwendet. Die molare Masse muss für das Standardverfahren zur Bestimmung der dermalen und inhalativen Absorption im Schritt 2 angegeben werden.                                                                                                                                                             \nn-Oktanol/Wasser Verteilungskoeffizient, log Kow: Als n-Oktanol/Wasser Verteilungskoeffizient (Kow) bezeichnet man das Verhältnis der Gleichgewichtskonzentrationen einer gelösten Substanz in einem Zweiphasensystem aus zwei weitgehend unmischbaren Lösungsmitteln n-Okatnol und Wasser. Der log Kow ist temperaturabhängig und wird typischerweise bei 25 °C gemessen. Der log Kow muss für das Standardverfahren zur Bestimmung der dermalen und inhalativen Absorption im Schritt 2 angegeben werden.                            \n                                                                                                                                                                                              \nFür weitere Informationen zu den physikalisch-chemischen Eigenschaften wird der ECHA Leitfaden R.7a empfohlen.","Propriétés physiques et chimiques :\nEtat physique : L’utilisateur peut choisir parmi quatre états de la matière : 1. gaz, 2. liquide, 3. solide (non-pulvérulent) ou 4. solide (pulvérulent). Vous trouverez des définitions des états physiques (gaz, liquide, solide) dans la section 1.0. de l’Annexe I (CLP).\nDensité : La densité (ρ) d’une substance se définit comme étant le quotient de la masse m par son volume    V : ρ = m/V ; unités SI [kg/m3].\nPression de vapeur saturante de la substance : La pression de vapeur saturante d’une substance est la pression de saturation d’une substance solide ou liquide à une température constante (généralement 20 ou 25ºC). En équilibre thermodynamique, la pression de vapeur d’une substance pure dépend uniquement de la température. L’outil utilise la température standard de 20ºC.\nConcentration typique de la substance : Veuillez saisir la concentration typique de la substance principale. Par exemple, une substance A contient trois composants : le composant principal B [90 %], une impureté C [4 %] et un additif D [6 %]. La concentration typique de 90 % de la substance principale sera saisie dans la cellule correspondante.\nMasse molaire : La masse molaire est égale à la masse [g] de la substance divisée par sa quantité [mol]. Les unités sont souvent exprimées en [mg/mol] ou [g/mol]. L’outil utilise les unités de [g/mol] pour la masse molaire. Veuillez saisir la masse molaire pour calculer les valeurs par défaut pour l’absorption cutanée et par inhalation à l’étape 2.\nCoefficient de partage n-octanol/eau, log Kow : Le coefficient de partage n-octanol/eau (Kow) est défini comme étant le rapport des concentrations d’équilibre d’une substance dissoute dans un système à deux phases constitué de n-octanol et d’eau, deux solvants immiscibles. La propriété est moyennement dépendante de la température et mesurée typiquement à 25°C. Veuillez saisir le log Kow pour calculer les valeurs par défaut pour l’absorption cutanée et par inhalation à l’étape 2.\n\nPour de plus amples informations sur les propriétés physiques et chimiques, veuillez consulter le guide technique R.7a de l’ECHA : Informations spécifiques aux effets.\n","Proprietà chimico-fisiche:\nStato fisico: L’utente può scegliere quattro differenti stati della materia: 1. gas, 2. liquido, 3. solido (polvere). Le definizioni degli stati fisici possono essere trovate nella sezione 1.0 dell’Allegato I (CAS).\nDensità: La densità (p) di una sostanza è definita come il quoziente tra la massa m e il suo volume V: ρ = m/V; unità SI [ kg/m3].\nPressione del vapore puro della sostanza: La pressione del vapore puro di una sostanza è definita come la pressione di saturazione al di sopra di una sostanza liquida o solida a temperatura costante (normalmente 20 o 25°C). All’equilibrio termodinamico, la pressione di vapore di una sostanza pura è solo in funzione della temperatura. L’applicazione usa la temperatura standard di 20°C.\nConcentrazione tipica della sostanza: inserire la concentrazione tipica della sostanza principale. Per esempio, una sostanza A contiene tre componenti: la componente principale B [90%], un’impurità C [4%] e un additivo D [6%]. La tipica concentrazione del 90% della sostanza principale dovrà essere inserita nella cella corrispondente.\nMassa molare: La massa molare è definita come la massa [g] della sostanza divisa per la sua quantità [mol]. Le unità sono spesso espresse in [mg/mol] o [g/mol]. L’applicazione usa le unità di [g/mol] per la massa molare. La massa molare deve essere inserita per calcolare i valori standard per l’assorbimento dermale e inalato nella fase 2.\nCoefficiente di partizione n-ottanolo/acqua, log Kow: Il coefficiente di partizione n-ottanolo/acqua (Kow) è definito come il rapporto delle concentrazioni di equilibrio di una sostanza disciolta in un sistema bi-fasico consistente di solventi ampiamente immiscibili in n-ottanolo e acqua. La proprietà è moderatamente dipendente dalla temperatura- e tipicamente misurata a 25°C. Il log Kow deve essere inserito per calcolare i valori standard per l’assorbimento dermale e inalato nella fase 2.\n\nPer maggiori informazioni circa le proprietà chimico-fisiche, consultare il documento «ECHA guidance document R.7a: Endpoint specific guidance».\n"]
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[null,"Leading health effect: \nThe leading health effect is the toxicological adverse effect that results in the most critical DNEL.         \nStudy guideline: \nGood Laboratory Practice (GLP): mandatory for toxicological and ecotoxicological testing.\nEU methods: Regulation (EC) No 440/2008 (Part B)                                                                                                                                                                              OECD method: Section 4: Health effects                                                                                                                                                                             For example: OECD guideline for testing of chemicals (No. 413): Subchronic inhalation toxicity: 90-day study.                          \nStudy duration: \nThe study duration refers to the duration of the experimental study. E.g. in OECD testing guideline No. 413, the study duration is 90 days.                                                                                                                                                                   \nSpecies: \nThe species used to conduct the experiment. E.g. in the OECD testing guideline No. 413, the preferred species is rat.                                                                                                                                                                                  Number of animals per dose group: \nThe number of animals used per dose group in the experiment. E.g. in the OECD testing guideline No. 413, at least 20 animals (10 males and 10 females) should be used for the experiment.                                                       \nAdministration route: \nThe route of administration is the path by which a substance is brought into contact with the body. E.g. in the OECD testing guideline No. 413, the administration route is inhalation. ","Die dominierende gesundheitliche Wirkung: \nDie dominierende adverse gesundheitliche Wirkung ist diejenige, die zum kritischsten DNEL führt.          \nTestrichtlinien: \nGute Laborpraxis (GLP): Obligatorisch für toxikologische und ökotoxikologische Tests.\nEU Prüfmethoden: Verordnung (EG) Nr. 440/2008 (Teil B)                                                                                                                                                                              OECD Testrichtlinien: Abschnitt 4: Gesundheitsauswirkungen                                                                                                                                                                                                       \nStudiendauer: \nDie Studiendauer bezieht sich auf die Dauer der experimentellen Studie. Beispielsweise für die OECD Testrichtlinie Nr. 413 beträgt die Studiendauer 90 Tage.                                                                                                                                                                   \nSpezies:\nDie für das Experiment verwendete Spezies. Beispielsweise ist die Ratte die bevorzugte Spezies in der OECD-Testrichtlinie Nr. 413.                                                                                                                                                                                   Anzahl Versuchstiere in der Studie: \nDie Anzahl der Versuchstiere, die im Experiment verwendet werden. Beispielsweise sollten gemäss der OECD-Testrichtlinie Nr. 413 mindestens 20 Versuchstiere (10 Männchen und 10 Weibchen) für das Experiment verwendet werden.                                                       \nVerabreichungsweg: \nDer Verabreichungsweg ist der Weg, auf dem ein Prüfstoff in Kontakt mit dem Körper gebracht wird. Beispielsweise ist die Inhalation der gewählte Verabreichungsweg in der OECD-Testrichtlinie Nr. 413.","Principal effet sur la santé :\nLe principal effet sur la santé est l’effet toxicologique indésirable survenant dans les DNEL les plus critiques.\nLignes directrices pour les études :\nBonnes pratiques de laboratoire (BPL) : obligatoires pour les essais toxicologiques et écotoxicologiques.\nMéthodes de l’UE : Règlement (CE) n° 440/2008 (Partie B)\nMéthode de l’OCDE : Section 4 : Effets sur la santé\nPar exemple : Ligne directrice de l’OCDE pour les essais de produits chimiques (n° 413) : Toxicité subchronique par inhalation : étude sur 90 jours.\nDurée de l’étude :\nLa durée de l’étude correspond à la durée de l’étude expérimentale. Par ex. pour la ligne directrice n° 413 de l’OCDE, la durée de l’étude est de 90 jours. \nEspèce :\nL’espèce utilisée pour l’étude. Par ex. dans la directive n° 413 de l’OCDE, l’espèce la plus utilisée est le rat.\nNombre d’animaux dans l’étude :\nLe nombre d’espèces utilisées dans l’étude. Par ex. dans la directive n° 413 de l’OCDE, au moins 20 animaux (10 mâles et 10 femelles) sont utilisés aux fins de l’étude.\nVoie d’administration :\nLa voie d’administration est celle par laquelle une substance est amenée à entrer en contact avec le corps. Par ex. dans la directive n° 413 de l’OCDE, la voie d’administration est l’inhalation.\n","Effetto principale per la salute:\nL’effetto principale per la salute è l’effetto tossicologico avverso che risulta nel DNEL più critico \nGuida allo studio:\nPratica del Buon Laboratorio (Good Laboratory Practice, GLP): obbligatorio per prove tossicologiche ed ecotossicologiche.\nMetodi UE: Regolamento (CE) N° 440/2008(Parte B)\nMetodo OCSE: Sezione 4: Effetti sulla salute\nPer esempio: Istruzione OCSE per prove con sostanze chimiche (N° 413): tossicità subcronica da inalazione: studio di 90 giorni.\nDurata dello studio:\nLa durata dello studio si riferisce alla durata dello studio sperimentale. Per es. per la guida delle prove OCSE N° 413 la durata dello studio è di 90 giorni.\nSpecie:\nLe specie usate per condurre l’esperimento. Per es. nella guida per le prove OCSE N° 413 la specie preferita è il ratto.\nNumero di animali nello studio:\nIl numero di specie usate nell’esperimento. Per es. nella guida dei test OCSE N° 413 almeno 20 animali (10 maschi e 10 femmine) dovrebbero essere usati per l’esperimento.\nVia somministrativa:\nLa via somministrativa è il percorso con cui una sostanza è portata a contatto con il corpo. Per es. nella guida dei test OCSE N° 413 la via somministrativa è l’inalazione.\n"]
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[null,"Effect type:                                                                                                                                                                                        \nSystemic effect: \nEffect that is normally observed distant from the site of first contact, i.e. after having passed through a physiological barrier (mucous membrane of the gastrointestinal tract or of the respiratory tract, or the skin) and becomes systemically available.                                                                                                                                                                                                  Local effect: \nEffect that is observed at the site of first contact, caused irrespective of whether a substance is systemically available.","Art des toxikologischen Effektes:                                                                                                                                                                                         Systemischer Effekt: \nWirkung, die normalerweise entfernt vom Ort des ersten Kontakts beobachtet wird, d.h. nachdem der Stoff eine physiologische Schranke (die Mukosa des Gastrointestinal- oder Respirationstrakts oder die Haut) durchdrungen hat und systemisch verfügbar wird.                                                                                                                        \nLokaler Effekt: \nWirkung, die am Ort des ersten Kontakts beobachtet wird, unanhängig davon, ob der Stoff systemisch verfügbar ist.","Type d’effet :\nEffet systémique :\nEffet habituellement observé à distance du site du premier contact, c.-à-d. après avoir traversé une barrière physiologique (membrane muqueuse du tube digestif ou des voies respiratoires, ou la peau) et qui entraîne une disponibilité systémique.\nEffet local :\nEffet observé au niveau du site du premier contact, provoqué sans tenir compte de la disponibilité systémique d’une substance.\n","Effetto tipo:\nEffetto sistemico:\nEffetto che è normalmente osservato a distanza dal luogo del primo contatto, ossia dopo aver attraversato una barriera fisiologica (membrana di mucosa del tratto gastrointestinale o del tratto respiratorio oppure della pelle), diventando sistematicamente disponibile.\nEffetto locale:\nEffetto che è osservato sul luogo del primo contatto, causato senza tener conto se una sostanza è sistemicamente disponibile.\n"]
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[null,"Toxicological endpoint:\nReproductive toxicity: \nThe term reproductive toxicity is used to describe the adverse effects induced by a substance on sexual function and fertility in adult males and females, developmental toxicity in the offspring and effects on or mediated via lactation. For more details on reproductive toxicity, please consult section R.7.6. of ECHA guidance document R.7a.\nOther effects: \nOther effects comprise all non-reprotoxic effects (local or systemic) that arise from repeated exposure to a substance for a particular time span. Repeated-dose toxicity studies provide information on possible general toxicological effects such as body-weight gain, relative organ- and tissue-weight or functional disturbances in organs and tissues in general. For more details on repeated-dose toxicity (other effects), please consult section R.7.5. of the ECHA guidance document R.7a.","Toxikologischer Endpunkt\nReproduktionstoxizität:\nDer Begriff der Reproduktionstoxizität beschreibt die Beeinträchtigungen von Sexualfunktion und Fruchtbarkeit bei Mann und Frau sowie die Entwicklungstoxizität bei den Nachkommen und Wirkungen auf oder über die Laktation. Weitere Einzelheiten über die Reproduktionstoxizität finden Sie im Abschnitt R.7.6. der ECHA Guidance R.7a und Abschnitt 3.7. der Verordnung (EG) Nr. 1272/2008 (CLP).\nAndere Effekte:\nDie anderen Effekte umfassen alle nicht reproduktions-toxischen Effekte (lokal oder systemisch), die nach wiederholter Exposition gegenüber einer Chemikalie über eine bestimmte Zeitspanne entstehen. Diese geben Aufschluss über mögliche allgemeine toxikologischen Auswirkungen wie beispielsweise die Gewichtszunahme, relative Organ- und Gewebegewicht oder Körperfunktionsstörungen in Organen und Geweben. Für weitere Einzelheiten über die Toxizität bei wiederholter Verabreichung (andere Effekte) finden Sie im Abschnitt R.7.5. der ECHA Guidance R.7a.","Point-limite toxicologique :\nToxicité pour la reproduction :\nLa toxicité pour la reproduction désigne les effets nocifs provoqués par une substance au niveau de la fonction sexuelle et de la fertilité chez les mâles et les femelles à l’âge adulte, la toxicité pour le développement de l’embryon ou du fœtus et les effets sur ou induits par la lactation. Pour plus de détails sur la toxicité pour la reproduction, veuillez consulter la section R.7.6. du guide R.7a de l’ECHA.\nAutres effets :\nLes autres effets englobent l’ensemble des effets non toxiques pour la reproduction (locaux ou systémiques) résultant d’une exposition répétée à une substance pendant un laps de temps donné. Des études de toxicité par administration répétée fournissent des informations sur des effets toxicologiques généraux potentiels tels que la prise de poids, la pondération organique et tissulaire relative ou des troubles fonctionnels au niveau des organes et des tissus d’une manière générale. Pour plus de renseignements sur la toxicité par administration répétée (autres effets), veuillez consulter la section R.7.5. du guide R.7a de l’ECHA.\n","Punto terminale tossicologico:\nTossicità riproduttiva:\nIl termine di tossicità riproduttiva è usato per descrivere gli effetti avversi indotti da una sostanza sulla funzione e sulla fertilità sessuale in adulti maschi e femmine, tossicità sviluppante nella prole ed effetti sull’allattazione oppure mediati per mezzo dell’allattazione. Per maggiori dettagli sulla tossicità riproduttiva, consultare la sezione R.76. della Guida ECHA R.7a.\nAltri effetti:\nAltri effetti comprendono tutti gli effetti non tossici per la riproduzione (locali o sistemici) che affiorano per ripetuta esposizione a una sostanza per un particolare arco di tempo. Studi di tossicità a dose ripetuta danno informazioni su effetti tossicologici possibili quali per es. aumento di peso corporeo, relativo al peso dell’organo e del tessuto o disturbi funzionali negli organi e nei tessuti in generale. Per maggiori dettagli sulla tossicità a dose ripetuta (altri effetti) consultare la sezione R.7.5 della Guida ECHA R.7a.\n"]
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[null,"NOAEL (No Observed Adverse Effect Level):  \nThe highest dose used in a toxicity study without sign of an adverse effect. The NOAEL is usually set for the oral or dermal route of exposure.\nNOAEC (No Observed Adverse Effect Concentration): \nThe highest exposure concentration used in a toxicity study without sign of an adverse effect. The NOAEC is usually set for the inhalation route of exposure.\nLOAEL (Lowest Observed Adverse Effect Level): \nThe lowest dose used in a toxicity study which indicates an adverse effect.                                                                                                                                                                                  LOAEC (Lowest Observed Adverse Effect Concentration):  \nThe lowest exposure concentration used in a toxicity study which indicates an adverse effect.  \nN(L)OAEL(C) fertility: \nN(L)OAEL(C) related to adverse effects on fertility.                  \nN(L)OAEL(C) development: \nN(L)OAEL(C) related to development toxicity.  \nAdverse effect:  \nAn adverse effect is a change in the morphology, physiology, growth, development, reproduction or life span of an organism, system, or (sub) population that results in an impairment of functional capacity, or an impairment of the capacity to compensate for additional stress, or an increase in susceptibility to other influences (OECD, 2003).                                                                                                                                                                     ","NOAEL (No Observed Adverse Effect Level):  \nDer NOAEL entspricht der höchsten Dosis, die in einer Toxizitätsstudie verwendet wurde, bei der keine adversen Wirkungen beobachtet wurden. Der NOAEL wird im Allgemeinen für die orale oder dermale Route abgeleitet.                                                                                                                                                                             \nNOAEC (No Observed Adverse Effect Concentration): \nDer NOAEC entspricht der höchsten Expositionskonzentration, die in einer Toxizitätsstudie verwendet wurde, bei der keine adversen Wirkungen beobachtet wurden. Der NOAEC wird im Allgemeinen für die inhalative Route abgeleitet.    \nLOAEL (Lowest Observed Adverse Effect Level):  \nDer LOAEL entspricht der tiefsten Dosis, die in einer Toxizitätsstudie verwendet wurde, bei der adverse Wirkungen beobachtet wurden.                                                                                 \nLOAEC (Lowest Observed Adverse Effect Concentration):    \nDer LOAEC entspricht der tiefsten Expositionskonzentration, die in einer Toxizitätsstudie verwendet wurde, bei der adverse Wirkungen beobachtet wurden.       \nN(L)OAEL(C) fertility: \nDieser N(L)OAEL(C) bezieht sich auf die Fruchtbarkeitstoxizität.         \nN(L)OAEL(C) development: \nDieser N(L)OAEL(C) bezieht sich auf die Entwicklungstoxizität.                                                                                          \nAdverser Effekt:  \nEin adverser Effekt entspricht einer Veränderung der Morphologie, Physiologie, Wachstum, Entwicklung, Reproduktion oder Lebensspanne eines Organismus, eines Systems oder (Sub-)Population, der zu einer Beeinträchtigung der Funktionsfähigkeit führt, oder einer Beeinträchtigung der Fähigkeit, zusätzliche Belastungen auszugleichen, oder zu einer erhöhten Anfälligkeit gegenüber anderen Einflüssen (OECD, 2003).\n                                                                                                                                                                                           ","NOAEL (No Observed Adverse Effect Level):  \nDose maximale utilisée dans le cadre d’une étude de toxicité sans signes d’effets nocifs. La NOAEL est généralement utilisée pour la voie d’exposition orale ou cutanée.\nNOAEC (No Observed Adverse Effect Concentration): \nConcentration d’exposition maximale utilisée dans le cadre d’une étude de toxicité sans signes d’effets nocifs. La NOAEC est généralement utilisée pour la voie d’exposition par inhalation.\nLOAEL (Lowest Observed Adverse Effect Level):  \nDose minimale utilisée dans le cadre d’une étude de toxicité indiquant un effet nocif.\nLOAEC (Lowest Observed Adverse Effect Concentration):    \nConcentration d’exposition minimale utilisée dans le cadre d’une étude de toxicité indiquant un effet nocif.\nN(L)OAEL(C) fertility: \nN(L)OAEL(C) fertility ayant une répercussion préjudiciable sur la fertilité.\nN(L)OAEL(C) development: \nN(L)OAEL(C) development liée à la toxicité pour le développement.\nEffet nocif :\nUn effet nocif est un changement dans la morphologie, la physiologie, la croissance, le développement, la reproduction ou la durée de vie d’un organisme, d’un système ou d’une (sous-)population se traduisant par une perte de capacités fonctionnelles ou une perte de capacité à compenser un stress additionnel ou une sensibilité accrue aux effets nocifs découlant d’autres influences environnementales (OCDE, 2003).\n","NOAEL (No Observed Adverse Effect Level, livello di non osservazione di effetto negativo):\nLa più alta dose usata in uno studio di tossicità senza un segno di effetto contrario. Il NOAEL è normalmente adottato per la via di esposizione dermale od orale.\nNOAEC (No Observed Adverse Effect Concentration, concentrazione di non osservazione di effetto negativo):\nLa più alta concentrazione espositiva usata in uno studio di tossicità senza un segno di effetto contrario. Il NOAEC è normalmente adottato per la via di esposizione inalativa.\nLOAEL (Lowest Observed Adverse Effect Level, livello minimo di osservazione di effetto negativo):\nLa dose più bassa usata in uno studio di tossicità, che indica un effetto contrario.\nLOAEC (Lowest Observed Adverse Effect Concentration, concentrazione minima con osservazione di effetto negativo):\nLa più bassa concentrazione di esposizione usata in uno studio di tossicità, che indica un effetto negativo.\nN(L)OAEL(C) fertilità:\nN(L)OAEL(C) collegato all’impatto negativo sulla fertilità.\nN(L)OAEL(C) sviluppo:\nN(L) OAEL(C) collegato allo sviluppo della tossicità.\nEffetto negativo:\nUn effetto negativo è un cambiamento nella morfologia, fisiologia, crescita, sviluppo, riproduzione o durata della vita di un organismo, sistema, o (sotto)popolazione che risulta in un indebolimento della capacità funzionale, o un indebolimento della capacità di compensazione di stress supplementare, oppure in un aumento della vulnerabilità verso altre influenze (OCSE, 2003).\n"]
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[null,"Administration route: \nThis corresponds to the route by which the substance is administrated in the experimental animal study.","Verabreichungsweg: \nDer Verabreichungsweg ist der Weg, auf dem ein Prüfstoff in Kontakt mit dem Körper gebracht wird.","Voie d’administration :\nCorrespond à la voie par laquelle la substance est administrée dans le cadre de l’étude expérimentale avec des animaux.\n","Via di somministrazione:\nLa via attraverso la quale la sostanza è somministrata nello studio sperimentale animale.\n"]
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[null,"Units:\nPlease enter the dose descriptor value and select the appropriate unit for the route of administration (bw = body weight). \nThe following units may be selected:\nOral: mg/kg bw/day; µg/kg bw/day; ng/kg bw/day; \nDermal (systemic effects): mg/kg bw/day; µg/kg bw/day; ng/kg bw/day\nDermal (local effects): mg/cm2/day; µg/cm2/day; ng/cm2/day\nInhalation: mg/m3; µg/m3; ng/m3; ppm; ppb\n","Einheiten: \nBitte geben Sie den Dosisdeskriptor-Wert ein und wählen Sie die gewünschte Einheit für den gewählten Verabreichungsweg (bw = Körpergewicht).\nDie folgenden Einheiten können ausgewählt werden:\nOral: mg/kg bw/day; µg/kg bw/day; ng/kg bw/day; \nDermal (systemicher Effekt): mg/kg bw/day; µg/kg bw/day; ng/kg bw/day\nDermal (lokaler Effekt): mg/cm2/day; µg/cm2/day; ng/cm2/day\nInhalation: mg/m3; µg/m3; ng/m3; ppm; ppb\n","Unités :\nVeuillez saisir la valeur du descripteur de dose et sélectionner l’unité appropriée correspondant à la voie d’administration (pc = poids corporel).\nLes unités suivantes peuvent être sélectionnées :\nOrale : mg/kg pc/jour ; µg/kg pc/jour ; ng/kg pc/jour ;\nCutanée (effets systémiques) : mg/kg pc/jour ; µg/kg pc/jour ; ng/kg pc/jour\nCutanée (effets locaux) : mg/cm²/jour ; µg/cm²/jour ; ng/cm²/jour\nInhalation : mg/m3 ; µg/m3 ; ng/m3 ; ppm ; ppb\n","Unità:\nInserire il valore descrittore della dose e selezionare l’unità appropriata per la via di somministrazione (bw= peso corporeo).\nPossono essere usate le seguenti unità:\nOrale: mg/kg bw/giorno; µg/kg bw/giorno; ng/kg bw/giorno;\nDermatico (effetti sistemici): mg/kg bw/giorno; µg/kg bw/giorno; ng/kg bw/giorno\nDermatico (effetti locali): mg/cm2/giorno; µg/cm2/giorno; ng/cm2/giorno\nInalazione: mg/m3; µg/ m3; ng/ m3; ppm; ppb \n"]
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[null,"Exposure route: \nDNELs may have to be derived for: \n- oral,\n- dermal and\n- inhalation exposure.\n\nThe user of the tool is only required to derive DNELs for the relevant routes of exposure. In all cases, it must be justified why the selected exposure routes have been considered as relevant and others as irrelevant. For local effects, the tool does not support route-to-route extrapolation. In order to proceed with the calculation, the same human exposure route must be selected as for the experimental animal.              ","Expositionspfad: \nAngesichts der unterschiedlichen Expositionspfade für die verschiedenen Bevölkerungsgruppen müssen DNELs möglicherweise für \n- orale, \n- dermale und\n- inhalative Exposition abgeleitet werden. \n\nEs ist nicht in jedem Fall erforderlich für alle genannten Pfade DNELs abzuleiten. Dabei muss begründet werden, warum die ausgewählten Expositionspfade als relevant angesehen werden und andere nicht. Die Pfad-zu-Pfad Extrapolation für lokale Effekte wird vom Tool nicht unterstützt.","Voie d’exposition :\nL’établissement de DNEL peut s’avérer nécessaire pour :\n- l’exposition orale (consommateurs/humains à travers l’environnement),\n- l’exposition cutanée (travailleurs/consommateurs, et potentiellement humains à travers l’environnement, par ex. via un sol contaminé) et\n- l’exposition par inhalation (travailleurs/consommateurs/humains à travers l’environnement).\n\nIl n’est pas toujours nécessaire d’établir des DNEL pour l’ensemble des voies évoquées. Il suffit à l’utilisateur de l’outil d’établir des DNEL pour les voies d’exposition concernées. Dans tous les cas, il convient d’expliquer pourquoi les voies d’exposition choisies ont été considérées comme pertinentes tandis que d’autres ont été jugées non pertinentes.\n\nPour les effets locaux, l’outil n’accepte aucune extrapolation de voie à voie. Afin d’effectuer le calcul, il faut sélectionner la même voie d’exposition humaine que pour l’animal de laboratoire.\n","Via di esposizione:\nÈ possibile derivare DNEL per:\n- esposizione orale (consumatori/esseri umani attraverso l’ambiente),\n- esposizione dermatica (lavoratori/consumatori, e potenzialmente esseri umani attraverso l’ambiente, per es., attraverso terreno contaminato) e\n- esposizione per inalazione (lavoratori/consumatori/esseri umani attraverso l’ambiente).\n\nNon è sempre necessario derivare DNEL per tutte le vie citate. L’utente dell’applicazione è tenuto soltanto a derivare DNEL per le vie d’esposizione rilevanti. Ad ogni modo, bisogna giustificare perché le vie d’esposizione selezionate sono state considerate rilevanti, mentre altre irrilevanti.\n\nPer effetti locali, l’applicazione non supporta l’estrapolazione via-a-via. Per procedere con il calcolo, la stessa esposizione umana deve essere selezionata come per la sperimentazione animale.\n"]
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[null,"Relevant population:\nDNELs may have to be derived for: \n- workers and \n- general population. The general population includes consumers and humans exposed via the environment.\n- Under certain circumstances it may also be necessary to derive DNELs for certain subpopulations, to cover a particular higher sensitivity (e.g. for children, pregnant women).\n\nIt is not always necessary to derive DNELs for all mentioned populations. In all cases, it must be justified why the selected population has been considered as relevant and others as irrelevant. \n","Relevante Bevölkerungsgruppe: \nDNELs sind möglicherweise für \n-Arbeiter und für die \n-Allgemeinbevölkerung abzuleiten. Die Allgemeinbevölkerung schliesst Verbraucher und die Exposition über die Umwelt ein.\n-Unter bestimmten Umständen kann es erforderlich sein, DNELs für bestimmte Bevölkerungsgruppen abzuleiten, die eine  höhere Empfindlichkeit gegenüber bestimmten Chemikalien aufweisen (z.B. für Kinder, Schwangere).\n\nEs ist nicht in jedem Fall erforderlich, für alle genannten Bevölkerungsgruppen DNELs abzuleiten. Dabei muss begründet werden, warum die ausgewählten Bevölkerungsgruppen als relevant angesehen werden und andere nicht. ","Population de référence :\nL’établissement de DNEL peut s’avérer nécessaire pour :\n- les travailleurs et\n- la population générale. La population générale englobe les consommateurs et les humains exposés à travers l’environnement, les DNEL étant généralement identiques pour ces deux catégories.\n- Dans certains cas, il peut également s’avérer nécessaire d’établir des DNEL pour certaines sous-populations, c.-à-d. couvrant une sensibilité accrue spécifique (par ex. pour les enfants). Il est également nécessaire de déterminer si un DNEL couvre une sous-population spécifique dès lors qu’une exposition spécifique de cette sous-population, par ex. exposition d’enfants via des jouets, nécessite une évaluation spécifique à cette sous-population.\n\nIl n’est pas toujours nécessaire d’établir des DNEL pour l’ensemble des populations évoquées. Les DNEL ont seulement besoin d’être établis pour les populations présentant un schéma d’exposition pertinent. Dans tous les cas, il convient d’expliquer pourquoi la population choisie a été considérée comme pertinente tandis que d’autres ont été jugées non pertinentes.\n","Popolazione pertinente:\nÈ possibile derivare DNEL per:\n- lavoratori e\n- per la popolazione generale. La popolazione generale include consumatori ed esseri umani esposti attraverso l’ambiente, con un DNEL normalmente identico per consumatori ed esseri umani per mezzo dell’ambiente.\n- In determinate circostanze potrebbe anche essere necessario ricavare DNEL per certe sottopopolazioni, ossia comprendendo una particolare maggiore sensibilità (per es. per bambini). Un’altra ragione per valutare se un DNEL copra una specifica sotto-popolazione è quando c’è una specifica esposizione da parte di questa sotto-popolazione, per es. esposizione di bambini attraverso giocattoli, che richiede una valutazione specifica della sottopopolazione.\nNon è necessario ricavare DNEL per tutte le popolazioni menzionate. I DNEL hanno bisogno di essere ricavati solo per le popolazioni con un modello d’esposizione rilevante. In ogni caso bisogna giustificare perché la popolazione selezionata è stata considerata rilevante e altre irrilevanti.\n"]
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[null,"Default values for bioavailability for the same exposure route in animals and humans:                                                         \noral-to-oral extrapolation: 1 (= 100 % / 100 %);                                                                                                                                                          \ndermal-to-dermal extrapolation: 1 (= 100 % / 100 %);                                                                                                                                                                     inhalation-to-inhalation extrapolation: 1 (= 100 % / 100 %)                                                                                                      \nDefault values for route-to-route extrapolation:                                                                                                                                \noral-to-inhalation extrapolation: 0.5 (= 50 % / 100 %);                                                                                                                                                           inhalation-to-oral extrapolation: 1 (= 100 % / 100 %);                                                                                                                                                                \noral-to-dermal extrapolation: 1 (= 100 % / 100 %);                                                                                                                                                        \ndermal-to-oral extrapolation: 1 (= 100 % / 100 %)\ninhalation-to-dermal extrapolation: 1 (= 100 % / 100 %)                                                                                                                                                           \ndermal-to-inhalation extrapolation:\nPercutaneous absorption through intact skin is highly dependent on the physico-chemical properties of chemicals, in particular molecular weight and lipophilicity. Molecules above a certain molecular weight are unlikely to cross an intact skin, and substances which are either too lipophilic or too hydrophilic have a low skin penetration.\nIn the default mode of the SECO-DNEL Tool 1.0, the cut-off points are set at a molecular weight > 500 g/mol and log Kow < -1 or > 4.  When this cut-off point is exceeded then a default dermal absorption factor of 10 % is set (EC, 2007). Otherwise, a default dermal absorption factor of 100 % is applied. In both cases, the inhalation absorption factor is set at 100 %. Please do not forget to enter the molecular weight and log Kow in the information part at the very top of the tool. \n                                                                                                                                                                                    \nDefinition: Route-to-route extrapolation is defined as the prediction of the total amount of a substance administered by one route that would produce the same toxic endpoint or response as that obtained for a given amount of a substance administered by another route (IGHRC, 2006). Most available animal data are obtained using the oral route, and the extrapolations most commonly carried out are from the oral to the dermal or inhalation route. Importantly, route-to-route extrapolation is only allowed for systemic effects (without first-pass effects), but not for local effects (e.g. inhalative lung irritation).      \n                                                                                                                 \nCalculation example: 30 % absorption for the oral route (animal) and 60 % absorption for the inhalation route (human) results into a route-to-route extrapolation factor of 0.5 (= 30% / 60%). In the DNEL results section of the tool, this value is referred to as ABSoral,an/ABSinh,hu = 0.5. \n\n           \n","Default Werte für die Bioverfügbarkeit eines Stoffes für dieselbe Expositionsroute:                                                         \nOral-zu-Oral Extrapolation: 1 (= 100 %/ 100 %);                                                                                                                                                          \nDermal-zu-Dermal Extrapolation: 1 (= 100 %/ 100 %);                                                                                                                                                                     Inhalation-zu-Inhalation Extrapolation: 1 (= 100 %/ 100 %)                                                                                                                                   \nDefault Werte für die Pfad-zu-Pfad Extrapolation:                                                                                                                                \nOral-zu-Inhalation Extrapolation: 0.5 (= 50 %/ 100 %);                                                                                                                                                           Inhalation-zu-Oral Extrapolation: 1 (= 100 %/ 100 %);                                                                                                                                                                \nOral-zu-Dermal Extrapolation: 1 (= 100 %/ 100 %);                                                                                                                                                        \nDermal-zu-Oral Extrapolation: 1 (= 100 %/ 100 %)\nInhalation-zu-Dermal Extrapolation: 1 (= 100 % / 100 %)                                                                                                                                                      \nDermal-zu-Inhalation Extrapolation:\nDie perkutane Absorption durch die intakte Haut ist stark abhängig von den physikalisch-chemischen Eigenschaften von Chemikalien, insbesondere des Molekulargewichts und deren Lipophilie. Für Moleküle, die ein bestimmtes Molekulargewicht überschreiten, ist es unwahrscheinlich, dass sie die intakte Haut passieren, und Stoffe, die entweder stark lipophil oder stark hydrophil sind, zeigen eine eher geringe Durchdringungsfähigkeit der Haut.\nIm Standardmodus (d.h. Default) des SECO-DNEL-Tool ist der Cut-Off-Wert bei einem Molekulargewicht von > 500 g/mol und bei einem log Kow-Wert < -1 oder > 4 programmiert. Wird dieser Cut-Off-Wert überschritten, so wird eine konservative Standardabsorption von 10% für die dermale Absorption angenommen (EG, 2007). Andernfalls wird eine Standardabsorption von 100 % für die Haut angenommen. In beiden Fällen wird für die Inhalation eine Standardabsorption von 100 % angenommen. Bitte vergessen Sie dazu nicht das Molekulargewicht und den log Kow im Informationsteil des Tools oben einzugeben.      \n                                                                                                                                                                              \nDefinition:  Die Pfad-zu-Pfad-Extrapolation wird definiert als die Übertragung einer Gesamtmenge eines Stoffes, die für einen Aufnahmeweg verabreicht wurde und einen bestimmten toxischen Effekt erzeugt, auf eine äquivalente Menge eines Stoffes für einen anderen Aufnahmeweg, die denselben toxischen Effekt erzeugt (IGHRC 2006). Die meisten verfügbaren tierexperimentellen Daten basieren auf orale Studien und die Extrapolation wird daher meistens von der oralen auf die dermale oder inhalative Expositionsroute durchgeführt. Wichtig ist, dass die Pfad-zu-Pfad-Extrapolation nur für systemische Wirkungen (ohne First-Pass-Effekte) erlaubt ist, aber nicht für lokale Effekte (z.B. inhalative Lungenreizung).\n                                                                                                \nBerechnungsbeispiel: Bei 30 % Absorption über den oralen Aufnahmeweg (Ratte) und 60 % Absorption über die Inhalation (Mensch) führt die Pfad-zu-Pfad Extrapolation zu einem Absorptionsquotienten von 0.5 (= 30% / 60%). Im DNEL Results Teil des Tools wird der Absorptionsquotient als ABSoral,an/ABSinh,hu = 0.5 ausgewiesen. \n\n           \n","Valeurs par défaut de biodisponibilité pour la même voie d’exposition chez les animaux et les humains :\nextrapolation orale/orale : 1 (= 100 %/ 100 %) ;\nextrapolation cutanée/cutanée : 1 (= 100 %/ 100 %) ;\nextrapolation inhalation/inhalation : 1 (= 100 %/ 100 %) \nValeurs par défaut pour l’extrapolation de voie à voie :\nextrapolation orale/inhalation : 0.5 (= 50 %/ 100 %) ;\nextrapolation inhalation/orale : 1 (= 100 %/ 100 %) ;\nextrapolation orale/cutanée : 1 (= 100 %/ 100 %) ;\nextrapolation cutanée/orale : 1 (= 100 %/ 100 %)\nextrapolation inhalation/cutanée et cutanée/inhalation :\nL’absorption percutanée via une peau intacte dépend beaucoup des propriétés physiques et chimiques des substances chimiques, et notamment de la masse moléculaire et des propriétés lipophiles. Au-delà d’une certaine masse moléculaire, il est peu probable que les molécules traversent la peau intacte, et les substances trop lipophiles ou trop hydrophiles ont un faible degré de pénétration dans la peau.\nDans le mode par défaut de l’outil SECO-DNEL 1.0, les points critiques sont paramétrés à une masse moléculaire de 500 g/mol et des valeurs log Kow inférieures à -1 ou supérieures à 4 afin de définir un facteur d’absorption cutanée par défaut modéré équivalent à 10 % d’absorption cutanée (CE, 2007). Dans le cas contraire, un facteur d’absorption cutanée par défaut de 100 % est défini. Dans les deux cas, le facteur d’absorption par inhalation est défini à 100 %. N’oubliez pas d’entrer la masse moléculaire et le log Kow dans le champ d’information tout en haut de l’outil.\nExplication :\nL’extrapolation de voie à voie se définit comme étant la prédiction du volume total d’une substance administrée par une voie qui entraînerait la même réponse ou le même point-limite toxique que ce qui a été obtenu pour un volume donné de substance administrée par une autre voie (IGHRC, 2006). La plupart des données animales disponibles sont obtenues par voie orale et les extrapolations les plus fréquentes sont par voie orale à cutanée ou par inhalation. Il est important de noter que l’extrapolation de voie à voie est seulement autorisée pour les effets systémiques (sans effets de premier passage), mais pas pour les effets locaux (par ex. irritation des poumons par inhalation).\nExemple de calcul :\n30 % d’absorption pour la voie orale (animal) et 60 % d’absorption par inhalation (humain) entraîne un facteur d’extrapolation de voie à voie de 0,5 (= 30 % / 60 %). Dans la section des résultats DNEL de l’outil, cette valeur est désignée ABSoral,an/ABSinh,hu = 0,5.\n","Valori standard per la biodisponibilità per la stessa via di esposizione in animali e in esseri umani:\nestrapolazione orale-ad-orale: 1(=100% / 100%)\nestrapolazione dermale-a-dermale: 1(=100%/ 100%)\nestrapolazione inalazione-a-inalazione: 1(=100%/ 100%)\nValori standard di estrapolazione via-a-via:\nestrapolazione orale-a-inalazione: 0,5(=50%/ 100%)\nestrapolazione inalazione-a-orale: 1 (=100%/ 100%)\nestrapolazione orale-a-dermale: 1(=100%/100%)\nestrapolazione dermale a orale: 1(=100%/ 100%)\nestrapolazione inalazione-a-dermale e dermale-a-inalazione:\nL’assorbimento percutaneo attraverso pelle intatta è altamente dipendente dalle proprietà psico-chimiche dei prodotti chimici e in particolare dal peso molecolare e dalla lipofilità. È improbabile che le molecole al di sopra di un certo peso molecolare attraversino la pelle intatta, mentre le sostanze troppo lipofile o troppo idrofile hanno una bassa penetrazione di pelle.\nNella modalità standard dell’applicazione DNEL-SECO (versione 1.0) i punti interrotti sono impostati a un peso molecolare di 500g/mol con valori di log Kow al di sotto di -1 o sopra 4 per impostare un fattore prudenziale standard di assorbimento dermale al 10% dell’assorbimento cutaneo (CE, 2007). Altrimenti, il fattore standard di assorbimento dermale è impostato al 100%. Importante: non dimenticare di inserire il peso molecolare e il log Kow, nella parte informativa della parte superiore dell’applicazione.\nSpiegazione:\nL’estrapolazione via-a-via è definita come predizione dell’ammontare totale di una sostanza somministrata da una via che produrrebbe lo stesso punto terminale tossico o risposta tossica come quello ottenuto per una determinata quantità di una sostanza somministrata da un’altra via (IGHRC, 2006). La maggior parte dei dati animali disponibili sono ottenuti usando la via orale, e le estrapolazioni eseguite più comunemente sono dalla via orale alla dermica o all’inalazione. È bene sapere che l’estrapolazione via-a-via è permessa soltanto per effetti sistemici (senza effetti di prima passata), ma non per effetti locali (per es. irritazione polmonare inalativa).\nEsempio di calcolo\nIl 30% di assorbimento per via orale (animale) e il 60% di assorbimento per via di inalazione (esseri umani) risulta in un fattore di estrapolazione via-a-via dello 0,5 (=30%/ 60%). Nella sezione dei risultati DNEL dell’applicazione, ci si riferisce a questo valore come ABSoral, an/ABSinh, hu=0,5.\n"]
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[null,"Experimental animals: \nSeven different experimental animals may be selected in the tool. Each of them has a specific standard respiratory volume [m3/kg bw] which is used to convert an inhalative exposure concentration (usually expressed in mg/m3 or ppm) to a dose per kg body weight (e.g. mg/kg bw/d), and, vice versa, to convert a dose in an inhalative exposure concentration. The standard respiratory volume of the experimental animal is calculated by applying an appropriate allometric scaling factor (e.g. 4 for rats) to account for the toxicokinetic differences between humans and animals (for more details, see information in the section on interspecies variability in step 3 of the tool). The following table lists the standard respiratory volume of each animal [m3/kg bw] for 8 hours, with human weight for workers = 70 kg:\n\nrat: 0.38 m3/kg bw/8 h\nmouse: 0.67 m3/kg bw/8 h\nhamster: 0.48 m3/kg bw/8 h\nguinea pig: 0.29 m3/kg bw/8 h\nrabbit: 0.23 m3/kg bw/8 h\nmonkey: 0.19 m3/kg bw/8 h\ndog: 0.13 m3/kg bw/8 h\n\nExample, rat: \n1. Standard respiratory volume, human (sRVHuman) = 6.7 m3/person/8 h; worker weight: 70 kg \n2. sRVHuman (per kg): 6.7 m3/person/70 kg = 0.0957 m3/kg bw/8h\n3. sRVrat = sRVHuman x Allometric Scaling Factor (rat) = 0.0957 * 4  = 0.38 m3/kg bw/8h","Versuchstiere: \nEs können im Tool sieben verschiedene Versuchstiere gewählt werden. Jedes dieser Versuchstiere hat ein bestimmtes Standard-Atemvolumen [m3/kg Körpergewicht (bw)], das erforderlich ist, um eine inhalative Expositionskonzentration (in der Regel in mg/m3 oder ppm ausgedrückt) in einen Dosiswert pro kg Körpergewicht (z.B. mg/kg bw/d) umzurechnen, und umgekehrt einen Dosiswert in eine inhalative Expositionskonzentration. Das Standard-Atemvolumen der Versuchstiere wird durch die Anwendung eines geeigneten allometrischen Skalierungsfaktors (z.B. 4 für Ratten) berechnet, um die toxikokinetischen Unterschiede zwischen Mensch und Tier zu quantifizieren (für mehr Details siehe Information im Schritt 3 über die Interspezies-Variabilität). In der folgenden Tabelle entsprechen die Standard-Atemvolumen der Tiere [in m3/ kg bw] für 8 Stunden und Arbeiter-Körpergewicht von 70 kg:\n\nRatte: 0.38 m3/kg bw/8 h\nMaus: 0.67 m3/kg bw/8 h\nHamster: 0.48 m3/kg bw/8 h\nMeerschweinchen: 0.29 m3/kg bw/8 h\nKaninchen: 0.23 m3/kg bw/8 h\nAffe: 0.19 m3/kg bw/8 h\nHund: 0.13 m3/kg bw/8 h\n\nBeispiel, Ratte: \n1. Standard-Atemvolumen, Mensch (sRVMensch) = 6.7 m3/Person/8 h; Arbeiter-Körpergewicht: 70 kg \n2. sRVMensch (pro kg): 6.7 m3/Person/70 kg = 0.0957 m3/kg bw/8h\n3. Standard-Atemvolumen, Ratte: sRVRatte= sRVMensch x Allometrischer Skalierungsfaktor (Ratte) = 0.0957 * 4 = 0.38 m3/kg bw/8h","Animaux de laboratoire :\nSept animaux de laboratoire différents peuvent être sélectionnés dans l’outil. Chacun a une capacité respiratoire standard spécifique [m3/kg pc] qui est utilisée pour convertir une concentration d’exposition par inhalation (généralement exprimée en mg/m3 ou ppm) en une dose par kg de poids corporel (par ex. mg/kg pc/d), et inversement pour convertir une dose en une concentration d’exposition par inhalation. La capacité respiratoire standard de l’animal de laboratoire est calculée en appliquant un coefficient d’ajustement allométrique approprié (par ex. 4 pour les rats) afin de tenir compte des différences toxicocinétiques entre les humains et les animaux (pour plus de renseignements, cf. les informations dans la section variabilité interspécifique à l’étape 3 de l’outil). Le tableau suivant correspond à une capacité respiratoire standard de l’animal [m3/kg pc] pour 8 heures et un poids humain pour les travailleurs = 70 kg :\n\nrat : 0,38 m3/kg pc/8 h\nsouris : 0,67 m3/kg pc/8 h\nhamster : 0,48 m3/kg pc/8 h\ncochon d’Inde : 0,29 m3/kg pc/8 h\nlapin : 0,23 m3/kg pc/8 h\nsinge : 0,19 m3/kg pc/8 h\nchien : 0,13 m3/kg pc/8 h\n\nExemple, rat :\n1. Capacité respiratoire standard, humain (sRVhumain) = 6,7 m3/personne/8 h ; poids du travailleur : 70 kg\n2. sRVhumain (par kg) : 6,7 m3/personne/70 kg = 0,0957 m3/kg pc/8h\n3. sRVrat = sRVhumain x coefficient d’ajustement allométrique (rat) = 0,0957 * 4 = 0,38 m3/kg pc/8h\n","Esperimenti animali:\nL’applicazione permette di selezionare sette differenti esperimenti animali. Ognuno di essi ha uno specifico volume respiratorio standard [m3/kg bw] che è usato per convertire una concentrazione d’esposizione inalativa (normalmente espressa in mg/m3 o ppm) a una dose per kg di peso corporeo (per es. Mg/kg bw/d), e viceversa, per convertire una dose in concentrazione d’esposizione inalativa. Il volume respiratorio standard dell’animale sperimentale è calcolato applicando un adeguato fattore di scala allometrico (per es. 4 per i ratti) per spiegare le differenze tra esseri umani e animali (per maggiori dettagli, cfr. le osservazioni nella sezione di variabilità interspecie nella fase 3 dell’applicazione). La seguente tabella corrisponde a un volume respiratorio standard dell’animale [m3/kg bw] per 8 ore e un peso corporeo umano per lavoratori= 70kg:\n\nratto: 0,38m3/kg bw/8h\ntopo: 0,67m3/kg bw/8h\ncriceto: 0,48m3/kg bw78h\nporcellino d’india: 0,29m3/kg bw/8h\nconiglio: 0,23m3/kg bw/8h\nscimmia: 0,19m3/kg bw/8h\ncane: 0,13m3/kg bw/8h\n\nEsempio, ratto:\n1. Volume respiratorio standard, esseri umani (sRVHuman)=6,7m3/persona/8h; peso lavoratore: 70kg\n2. sRVHuman (per kg): 6,7m3/person/70kg= 0,0957m3/kg bw/8h\n3. sRVrat= sRVHuman x Fattore Scalare Allometrico (ratto) 0 0,0957*4= 0,38 m3/kg bw/8h\n"]
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[null,"Differences in experimental and human exposure conditions: \nDose-dependent default correction factor for differences in experimental and human exposure conditions:\nworker:\noral: 1.4 (= 7/5); hours/day (animal/human): not applicable (n.a.)  &  days/week (animal/human): 7/5 \ndermal: 0.75 (= 6/8 x 5/5); hours/day (animal/human): 6/8  &  days/week (animal/human): 5/5 \ninhalation: 0.75 (= 6/8 x 5/5); hours/day (animal/human): 6/8  &  days/week (animal/human): 5/5 \nconsumer (CED: Consumer Exposure Duration):\noral: 1 (= 7/7); hours/day (animal/human): not applicable (n.a.)  &  days/week (animal/human): 7/7 \ndermal: 6/CDE x 5/7; hours/day (animal/human): 6/CDE  &  days/week (animal/human): 5/7 \ninhalation: 6/CDE x 5/7; hours/day (animal/human): 6/CDE  &  days/week (animal/human): 5/7 \nhuman via the environment:\noral: 1 (= 7/7); hours/day (animal/human): not applicable (n.a.)   &  days/week (animal/human): 7/7 \ndermal: 0.179 (= 6/24 x 5/7); hours/day (animal/human): 6/24  &  days/week (animal/human): 5/7 \ninhalation: 0.179 (= 6/24 x 5/7); hours/day (animal/human): 6/24  &  days/week (animal/human): 5/7 \n\nConcentration-driven default correction factor for differences in experimental and human exposure conditions:\nFor all exposure routes and relevant populations: 1\n\nExplanation:\nThe exposure conditions for experimental animals in a toxicity study may differ from that of target populations. For example, in repeated-dose inhalation studies, exposure normally is 6 hours per day, which differs from that for workers (assumed 8 hours per day), humans via the environment (assumed 24 hours per day), and consumers (assumed 1-24 hours per day, depending on the exposure scenario). If the toxic effect is driven by the total (accumulated) dose, or depends on both total dose and the exposure concentration, concentration–time corrections (i.e. time scaling) must be applied. Time scaling is not appropriate when the toxic effect is mainly driven by the exposure concentration (as for irritation). A useful tool for time scaling is the modified Haber’s law (Cn x t = k, where ‘C’ is the concentration, ‘n’ is a regression coefficient, ‘t’ is the exposure time and ‘k’ is a constant). Please note that for the oral route the experimental exposure conditions expressed in hours/day are generally not applicable.\nExample:\nA NOAEC is available from a rat 6 h/d inhalation study. In most cases, this experimental NOAEC must be corrected by a factor 0.75 (6/8) for workers, or, for humans via the environment, by a factor of 0.25 (6/24). In these cases the regression coefficient n = 1 has been considered as the most appropriate value. \n","Unterschiede in den Expositionsbedingungen Tier/Mensch: \nDosis-abhängiger Default-Korrekturfaktor für die Berechnung der Unterschiede in den Expositionsbedingungen Tier/Mensch:\nArbeiter:\nOral: 1.4 (= 7/5); Stunden/Tag (Tier/Mensch): n.a.  &  Tage/Woche (Tier/Mensch): 7/5 \nDermal: 0.75 (= 6/8 x 5/5); Stunden/Tag  (Tier/Mensch): 6/8  &  Tage/Woche  (Tier/Mensch): 5/5 \nInhalation: 0.75 (= 6/8 x 5/5); Stunden/Tag  (Tier/Mensch): 6/8  &  Tage/Woche  (Tier/Mensch): 5/5 \nVerbraucher (CED: Expositionsdauer Verbraucher):\nOral: 1 (= 7/7); Stunden/Tag  (Tier/Mensch): n.a.  &  Tage/Woche  (Tier/Mensch): 7/7 \nDermal: 6/CDE x 5/7; Stunden/Tag  (Tier/Mensch): 6/CDE  &  Tage/Woche  (Tier/Mensch): 5/7 \nInhalation: 6/CDE x 5/7; Stunden/Tag  (Tier/Mensch): 6/CDE  &  Tage/Woche  (Tier/Mensch): 5/7 \nMensch exponiert über die Umwelt:\nOral: 1 (= 7/7); Stunden/Tag  (Tier/Mensch): n.a.  &  Tage/Woche (Tier/Mensch): 7/7 \nDermal: 0.179 (= 6/24 x 5/7); Stunden/Tag  (Tier/Mensch): 6/24  &  Tage/Woche (Tier/Mensch): 5/7 \nInhalation: 0.179 (= 6/24 x 5/7); Stunden/Tag  (Tier/Mensch): 6/24  &  Tage/Woche  (Tier/Mensch): 5/7 \nKonzentrations-abhängiger Default-Korrekturfaktor für die Berechnung der Unterschiede in den Expositionsbedingungen Tier/Mensch:\nFür alle Expositionsrouten und relevante Populationen : 1\nErklärung: Die Expositionsbedingungen für die Versuchstiere in einer Toxizitätsstudie können sich von denen der Zielgruppe unterscheiden. Beispielsweise beträgt bei Inhalationsstudien mit wiederholter Exposition die Exposition normalerweise 6 Stunden pro Tag und unterscheidet sich damit von der bei Beschäftigten am Arbeitsplatz (Annahme: 8 Stunden pro Tag), der Bevölkerung über die Umwelt (Annahme: 24 Stunden am Tag) und Verbrauchern (Annahme: 1 – 24 Stunden pro Tag, abhängig vom Expositionsszenario). Sofern die toxische Wirkung von der (akkumulierten) Gesamtdosis oder von beidem, der Gesamtdosis und der Expositionskonzentration, bestimmt wird, sind Konzentrations-Zeit-Anpassungen (d. h. Zeitextrapolation) vorzunehmen. Eine Zeitextrapolation ist nicht angebracht, wenn die toxische Wirkung im Wesentlichen von der Expositionskonzentration bestimmt wird (wie bei der Reizung). Ein nützliches Instrument zur Berechnung der Zeitextrapolation ist die modifizierte Haber'sche Regel (Cn x t = k, wobei \"C\" für die Konzentration, \"n\" den Regressionskoeffizienten, \"t\" die Expositionszeit und \"k\" eine Konstante stehen). \nBeispiel: Liegt zum Beispiel ein NOAEC aus einer 6 h/d-Inhalationsstudie an Ratten vor, so muss dieser NOAEC in den meisten Fällen für Beschäftigte um den Faktor 0.75 (6/8) korrigiert werden oder für Menschen exponiert über die Umwelt um einen Faktor 0.25 (6/24) (In diesem Fall wurde der Regressionskoeffizient n = 1 angenommen).","Différences relatives aux conditions expérimentales et d’exposition humaine :\nFacteur de correction par défaut en fonction de la dose pour des différences au niveau des conditions expérimentales et d’exposition humaine :\ntravailleur :\noral : 1,4 (= 7/5) ; heures/jour (animal/humain) : sans objet (s.o.) & jours/semaine (animal/humain) : 7/5\ncutané : 0,75 (= 6/8 x 5/5) ; heures/jour (animal/humain) : 6/8 & jours/semaine (animal/humain) : 5/5\ninhalation : 0,75 (= 6/8 x 5/5) ; heures/jour (animal/humain) : 6/8 & jours/semaine (animal/humain) : 5/5\nconsommateur (DEC : Durée d’Exposition du Consommateur) :\noral : 1 (= 7/7) ; heures/jour (animal/humain) : sans objet (s.o.) & jours/semaine (animal/humain) : 7/7\ncutané : 6/DEC x 5/7 ; heures/jour (animal/humain) : 6/DEC & jours/semaine (animal/humain) : 5/7\ninhalation : 6/DEC x 5/7 ; heures/jour (animal/humain) : 6/DEC & jours/semaine (animal/humain) : 5/7\nhumain via l’environnement :\noral : 1 (= 7/7) ; heures/jour (animal/humain) : sans objet (s.o.) & jours/semaine (animal/humain) : 7/7\ncutané : 0,179 (= 6/24 x 5/7) ; heures/jour (animal/humain) : 6/24 & jours/semaine (animal/humain) : 5/7\ninhalation : 0,179 (= 6/24 x 5/7) ; heures/jour (animal/humain) : 6/24 & jours/semaine (animal/humain) : 5/7\nFacteur de correction par défaut induit par la concentration pour des différences au niveau des conditions expérimentales/d’exposition humaine :\nPour toutes les voies d’exposition et populations de référence : 1\nExplication : Dans le cadre d’une étude de toxicité, les conditions d’exposition pour les animaux de laboratoire peuvent différer de celle des populations cibles. Par exemple, lors d’études sur l’inhalation par administration répétée, l’exposition normale est de 6 heures par jour, ce qui diffère de celle préconisée pour les travailleurs (8 heures par jour), l’humain à travers l’environnement (24 heures par jour), et les consommateurs (1 à 24 heures par jour, en fonction du scénario d’exposition). Si l’effet toxique est induit par la dose totale (accumulée) ou dépend à la fois de la dose totale et de la concentration d’exposition, des corrections doivent être apportées à la durée de concentration (c.-à-d. ajustement de l’échelle de temps). L’ajustement de l’échelle de temps n’est pas indiqué lorsque l’effet toxique est principalement induit par la concentration d’exposition (comme pour l’irritation). Un outil pratique pour l’ajustement de l’échelle de temps est la loi de Haber modifiée (Cn x t = k, où « C » désigne la concentration, « n » un coefficient de régression, « t » la durée d’exposition et « k » une constante). Veuillez noter que pour la voie orale, les conditions d’exposition expérimentales exprimées en heures/jour ne sont généralement pas applicables.\nExemple : Une CSENO est fournie par une étude sur l’inhalation d’un rat à raison de 6 h/j. Dans la plupart des cas, cette NOAEC expérimentale doit être corrigée par un facteur de 0,75 (6/8) pour les travailleurs ou par un facteur de 0,25 (6/24) pour l’humain à travers l’environnement. (Dans ces cas, le coefficient de régression n=1 a été considéré comme étant la valeur la plus appropriée).\n","Differenze di condizioni nell’esposizione sperimentale e umana :\nFattore di correzione del difetto a dipendenza della dose per differenze di condizioni nell’esposizione umana e sperimentale:\nLavoratore:\nOrale: 1,4 (=7/5), ore/giorno (animale/essere umano): non applicabile (n.a.) & giorni/settimana (animale/essere umano): 7/5\nDermale: 0,75 (=6/8x5/5); ore/giorno (animale/essere umano): 6/8 & giorni/settimana (animale/essere umano): 5/5\nInalazione: 0,75 (=6/8x5/5); ore/giorno (animale/essere umano): 6/8 & giorni/settimana (animale/essere umano): 5/5\nConsumatore (CED: Durata Esposizione Consumatore):\nOrale: 1 (=7/7); ore/giorno (animale/essere umano): non applicabile (n.a.) & giorni/settimana (animale/essere umano): 7/7\nDermale: 6/CDE x 5/7; ore/giorno (animale/essere umano): 6/CDE & giorni/settimana (animale/essere umano): 5/7\nInalazione: 0,75 (=6/8 x 5/5); ore/giorno (animale/essere umano): 6/CDE & giorni/settimana (animale/essere umano): 5/7\nEsseri umani attraverso l’ambiente:\nOrale: 1 (=7/7); ore/giorno (animale/essere umano): non applicabile (n.a.) & giorni/settimana (animale/essere umano):7/7\nDermale: 0,179 (=6/24 x 5/7); ore/giorno (animale/essere umano): 6/24 & giorni/settimana (animale/essere umano): 5/7\nInalazione: 0,179 (=6/24 x 5/7); ore/giorno (animale/essere umano): 6/24 & giorni/settimana (animale/essere umano): 5/7\nFattore di correzione standard in base alla concentrazione per differenze nell’esp./condizioni di esposizione essere umano:\nPer tutte le vie di esposizione e popolazioni rilevanti: 1\nSpiegazione: Le condizioni di esposizione per esperimenti animali in uno studio di tossicità possono differire da quelle di popolazioni target. Per esempio, in ripetuti studi per la dose d’inalazione, l’esposizione è normalmente di 6 ore al giorno, che differisce da quella per lavoratori (presupposto: 8 ore al giorno), esseri umani per via ambientale (presupposto: 24 ore al giorno), e consumatori (presupposto: 1-24 ore al giorno, a dipendenza dallo scenario di esposizione). Se l’effetto tossico è guidato dalla dose totale (accumulata), oppure dipende da entrambe, dose totale e concentrazione di esposizione, bisogna applicare correzioni di concentrazione/tempo (ossia tempo scalare). Il tempo scalare non è appropriato quando l’effetto tossico è principalmente guidato dalla concentrazione di esposizione (come per l’irritazione). Uno strumento utile per il tempo scalare è la legge di Haber modificata (Cn x t = k, dove C è la concentrazione, « n » è il coefficiente di regressione, « t » è il tempo di esposizione e « k » è una costante). Importante: per la via orale le condizioni di esposizione sperimentale espresse in ore/giorno non sono generalmente applicabili.\nEsempio: Un NOAEC può essere ricavato da un ratto con uno studio di inalazione 6 h/d. Per i lavoratori, nella maggior parte dei casi, questo NOAEC sperimentale va corretto con un fattore di 0,75 (6/8) oppure, per gli esseri umani per via ambientale, con un fattore di 0,25 (6/24) (In questi casi il coefficiente di regressione n=1 è stato considerato il valore più appropriato).\n"]
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[null,"Please calculate the starting point corrected dose descriptor value and select the appropriate units for the route of exposure (bw = body weight). The starting point correction is either run by selecting the exposure units or by clicking the Run button. \nThe following units can be selected:\nOral: mg/kg bw/day; µg/kg bw/day; ng/kg bw/day; \nDermal (systemic effects): mg/kg bw/day; µg/kg bw/day; ng/kg bw/day\nDermal (local effects): mg/cm2/day; µg/cm2/day; ng/cm2/day\nInhalation: mg/m3; µg/m3; ng/m3; ppm; ppb\n","Bitte berechnen Sie den startpunkt-korrigierten Dosisdeskriptor und wählen Sie eine geeignete Einheit für den gewählten Expositionsweg (bw = Körpergewicht). Der Berechnung wird entweder direkt durch die Auswahl der Einheit oder durch Anklicken der Schaltfläche Run ausgelöst.\nDie folgenden Einheiten können ausgewählt werden:\nOral: mg/kg bw/day; µg/kg bw/day; ng/kg bw/day; \nDermal (systemische Effekte): mg/kg bw/day; µg/kg bw/day; ng/kg bw/day\nDermal (lokale Effekte): mg/cm2/day; µg/cm2/day; ng/cm2/day\nInhalation: mg/m3; µg/m3; ng/m3; ppm; ppb\n"]
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[null,"Default assessment factors for interspecies variability:                                                                                                                                                                                                        \n1. Allometric scaling factor:                                                                                                                                                                                                                \nsystemic effects (oral or dermal route): rat: 4; mouse: 7; hamster: 5; guinea pig: 3; rabbit: 2.4; monkey: 2; dog: 1.4.                                                                                                                                                                                                                                                                                                   systemic effects (inhalation route): 1.                                                                                                                                                                                                                                                 local effects: 1.                                                                                                                                                                                            \n2. Remaining differences:                                                                                                                                                                                                                                                   \nsystemic effects: 2.5                                                                                                                                                                                                                                                local effects: 2.5     \n                                                                                                                                                                                  \nExplanations:  \nThe interspecies differences result from variation in the sensitivity of species due to differences in toxicokinetics and toxicodynamics. Some of the toxicokinetic differences can be explained by differences in body size (and related differences in basal metabolic rate).                                                                                                                                           Systemic effects: \nIf no substance-specific data are available, the standard procedure is to correct for differences in metabolic rate (allometric scaling) and to apply an additional factor of 2.5 for other or remaining interspecies differences, i.e. toxicokinetic differences not related to metabolic rate (small part) and toxicodynamic differences (larger part).                                                                                                                                                                                       Allometric scaling factors do not have to be calculated if the relevant exposure route is inhalation (i.e. allometric scaling factor = 1), because respiratory rates depend directly on caloric demand.\nLocal effects:                                                                                                                                                                                                       No allometric scaling factor is required for local toxic effects, because they are independent of the basal metabolic rate. For the remaining uncertainties in kinetic (at a smaller extent) and in dynamic (at a larger extent) interspecies differences, consideration of the mechanism of toxicity is crucial, e.g. if the effect is a simple destruction of membranes due to the physicochemical properties (e.g. pH) of the chemical concerned as opposed to a mechanism involving local metabolism.\n     \n                              ","Standard Extrapolationsfaktoren für die Interspezies-Variabilität:                                                                                                                                                                                                                \n1. Allometrischer Skalierungsfaktor:                                                                                                                                                                                                                \nSystemische Effekte (oraler oder dermaler Aufnahmeweg): Ratte: 4; Maus: 7; Hamster: 5; Meerschweinchen: 3; Kaninchen: 2.4; Affe: 2; Hund: 1.4.                                                                                                                                                                                                                                                                                                   Systemische Effekte: (inhalativer Aufnahmeweg): 1.                                                                                                                                                                                                                                                 Lokale Effekte: 1.                                                                                                                                                                                            \n2. Weitere Unterschiede:                                                                                                                                                                                                                                                   \nSystemische Effekte: 2.5                                                                                                                                                                                                                                                Lokale Effekte: 2.5     \n                                                                                                                                                                                  \nErklärung:  \nInterspeziesunterschiede resultieren aus der Variation der Empfindlichkeit von Arten aufgrund von toxikokinetischen und toxikodynamischen Unterschieden. Einige dieser toxikokinetischen Unterschiede können durch Unterschiede im Körpergewicht (und damit zusammenhängenden Unterschieden in der basalen Stoffwechselrate) erklärt werden.         \nSystemische Effekte: \nDie Standardvorgehensweise für die Bestimmung der Interspezies-Variabilität quantifiziert die Unterschiede in der Stoffwechselrate (allometrisches Scaling) und die Anwendung eines zusätzlichen Faktors von 2.5 für andere Interspeziesunterschiede. Diese beinhalten (zu einem kleinen Teil) toxikokinetische Unterschiede, die nicht in Zusammenhang mit der Stoffwechselrate stehen, und (zum grösseren Teil) Unterschiede in der Toxikodynamik.  \nBitte beachten Sie, dass allometrische Skalierungsfaktoren nicht für die inhalative Route berechnet werden müssen (d.h. allometrischer Skalierungsfaktor = 1), da die Atemfrequenz direkt vom basalen Grundumsatz abhängt.                                                                                                                                                                                                                                                                                         Lokale Effekte: \nKein allometrisches Scaling wird für die lokalen Effekte vorgenommen, da lokale Wirkungen unabhängig vom Grundumsatz sind (Faktor für allometrisches Scaling: 1). Für die verbleibenden Unsicherheiten hinsichtlich (zum kleineren Teil) kinetischer und (zum grösseren Teil) dynamischer Interspeziesunterschiede ist der Wirkungsmechanismus ausschlaggebend, z.B. wenn die Wirkung schlicht auf einer Zerstörung von Membranen durch physikalisch-chemische Eigenschaften (z.B. pH) der betrachteten Chemikalie beruht im Gegensatz zu einem Mechanismus, der lokale Metabolisierung beinhaltet.\n     \n                              ","Facteurs d’évaluation par défaut pour la variabilité interspécifique :\n1. Coefficient d’ajustement allométrique :\nEffets systémiques (voie orale ou cutanée) : rat : 4 ; souris : 7 ; hamster : 5 ; cochon d’Inde : 3 ; lapin : 2,4 ; singe : 2 ; chien : 1,4.\nEffets systémiques (inhalation) : 1.\nEffets locaux : 1.\n2. Différences restantes :\nEffets systémiques : 2,5\nEffets locaux : 2,5\n\nExplications :\nLes différences interspécifiques résultent d’une variation de sensibilité des espèces due à des différences toxicocinétiques et toxicodynamiques. Certaines des différences toxicocinétiques peuvent s’expliquer par des différences de taille (et des différences apparentées au niveau du métabolisme basal).\nEffets systémiques :\nEn l’absence de données spécifiques à la substance, la procédure standard consiste à corriger les différences au niveau du taux métabolique (ajustement allométrique) et à appliquer un facteur supplémentaire de 2,5 pour d’autres différences interspécifiques ou restantes, c.-à-d. différences toxicocinétiques sans rapport avec le taux métabolique (petite partie) et différences toxicodynamiques (partie plus importante).\nLes coefficients d’ajustement allométrique n’ont pas besoin d’être calculés si la voie d’exposition pertinente est l’inhalation (c.-à-d. coefficient d’ajustement allométrique = 1) étant donné que la fréquence respiratoire dépend directement de la demande de calories. Autrement dit, les résultats de l’étude sont (implicitement) extrapolés aux humains sur la base du taux métabolique.\nEffets locaux :\nAucun coefficient d’ajustement allométrique n’a besoin d’être appliqué pour les effets toxiques locaux étant donné qu’ils sont indépendants du métabolisme basal. Pour les effets locaux sur la peau, les yeux et le tube digestif via une simple destruction des membranes, un facteur de 1 (au lieu de 2,5) peut également être appliqué pour les différences restantes concernant la variabilité interspécifique.\n","Fattori standard di valutazione per variabilità interspecie :\n1. Fattore scalare allometrico:\nEffetti sistemici (via orale e dermale): ratto: 4; topo: 7; criceto: 5; porcellino d’india: 3; coniglio: 2,4; scimmia: 2; cane: 1,4; \nEffetti sistemici (via inalazione): 1\nEffetti locali: 1\n2. Differenze rimanenti:\nEffetti sistemici:2,5\nEffetti locali: 2,5\n\nSpiegazioni:\nLe differenze interspecie risultano dalla variazione nella sensibilità delle specie, dovuta a differenze nella tossicocinetica e nella tossicodinamica. Alcune delle differenze tossicocinetiche possono essere spiegate per via delle differenze nelle dimensioni corporee (e correlate differenze nel tasso metabolico basale).\nEffetti sistemici:\nSe non sono disponibili dati specifici della sostanza, la procedura standard è quella di correggere per differenze nel tasso metabolico (scala allometrica) e di applicare un ulteriore fattore di 2,5 per le altre differenze, o per differenze interspecie restanti, ossia differenze tossicocinetiche non correlate al tasso di metabolismo (piccola parte) e differenze tossicocinetiche (larga parte).\nI fattori scalari allometrici non devono essere calcolati se la pertinente via d’esposizione è l’inalazione (ossia fattore scalare allometrico=1), perché i tassi respiratori dipendono direttamente dalla domanda di calorie. Ciò vuol dire che i risultati degli studi sono (implicitamente) estrapolati per gli esseri umani sulla base del tasso scalare metabolico.\nEffetti locali:\nNon è necessario applicare alcun fattore scalare allometrico per effetti tossici locali, perché sono indipendenti dal tasso metabolico basale. Per effetti locali sulla pelle, occhi e tratto Gl, attraverso semplice distruzione delle membrane, anche un fattore di 1 (invece di 2,5) può essere applicato per le rimanenti differenze nella variabilità interspecie.\n"]
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[null,"Default assessment factors for intraspecies variability:                                                                                                                                                                                                                \nworker: 5                                                                                                                                                                                                                                                consumer: 10\nhuman via the environment: 10   \n                                                                                                                                                                                        \nExplanations: \nHumans differ in sensitivity to toxic insult due to many different biological factors such as genetic polymorphism affecting e.g. toxicokinetics/metabolism, age, gender, life style or health status. These differences can be the result of genetic and/or environmental influences. This intraspecies variation is greater in humans than in more inbred experimental animal populations. \nFor workers, the standard procedure for threshold effects applies a default assessment factor of 5, based on the fact that this sub-population does not cover the very young, the very old, and the very ill.                                                                                                                         \nFor the general population (i.e. consumers and humans via the environment), the standard procedure for threshold effects applies a default assessment factor of 10. For children, a higher intraspecies assessment factor may be considered.                                                                                                     ","Standard Extrapolationsfaktor für die Intraspezies Unterschiede:                                                                                                                                                                                                                \nArbeiter: 5                                                                                                                                                                                                                                                Verbraucher: 10\nExposition über die Umwelt: 10   \n                                                                                                                                                                                       \nErklärung: \nMenschen unterscheiden sich in ihrer Empfindlichkeit gegenüber einer toxischen Schädigung aufgrund einer Vielzahl biologischer Faktoren wie etwa genetischer Polymorphismen, die z.B. Toxikokinetik/Metabolismus beeinflussen, sowie Alter, Geschlecht, Gesundheits- und Ernährungsstatus. Diese Unterschiede können das Ergebnis genetischer und/oder umweltbedingter Einflüsse sein. Die Intraspeziesvariabilität ist beim Menschen grösser als bei den stärker ingezüchteten Versuchstierstämmen.                                                                              \nFür die Arbeitnehmenden, wird für die Intraspezies-Unterschiede ein Standard-Extrapolationsfaktor von 5 verwendet, basierend auf der Tatsache, dass diese Subpopulation nicht die die ganz jungen, die sehr alten, und die sehr kranken Menschen enthält.                                                                                                                                                                                     Für die allgemeine Bevölkerung, wird für die Intraspezies-Unterschiede ein Standard-Extrapolationsfaktor von 10 verwendet. Ein höherer Intraspeziesfaktor sollte für Kinder und Schwangere in Betracht gezogen werden.","Facteurs d’évaluation par défaut pour la variabilité intraspécifique :\nTravailleur : 5\nConsommateur : 10\nHumain via l’environnement : 10\n\nExplications :\nLa sensibilité des humains aux agressions toxiques diverge en raison de nombreux facteurs biologiques différents comme le polymorphisme génétique affectant par ex. la toxicocinétique/le métabolisme, l’âge, le sexe, le style de vie ou l’état de santé. Ces différences peuvent résulter d’influences génétiques et environnementales. Cette variation intraspécifique est plus importante chez les humains que chez les animaux de laboratoire plus consanguins.\nPour les travailleurs, un facteur d’évaluation par défaut de 5 doit être utilisé en tant que procédure standard pour les effets de seuil, étant donné que cette sous-population ne couvre pas les personnes très jeunes, très âgées et très malades.\nPour la population générale (c.-à-d. consommateurs et humains via l’environnement), un facteur d’évaluation par défaut de 10 est appliqué en tant que procédure standard pour les effets de seuil. Ce facteur est jugé suffisant pour protéger la majeure partie de la population. Pour les enfants, un facteur d’évaluation intraspécifique plus élevé peut être pris en compte.\n","Fattori standard di valutazione per variabilità interspecie:\nLavoratori: 5\nConsumatori: 10\nEsseri umani attraverso l’ambiente: 10\n\nSpiegazioni:\nGli esseri umani differiscono nella sensibilità all’offesa tossica, dovuta a molti fattori biologici differenti, quale il polimorfismo genetico che influenza per es. tossicocinetica/metabolismo, età, genere, stile di vita o stato di salute. Queste differenze possono essere il risultato di influenze genetiche e ambientali. Questa variazione interspecie è maggiore negli esseri umani che in una più congenita popolazione sperimentale animale.\nPer i lavoratori, come procedimento standard per effetti soglia bisogna usare un fattore di valutazione standard di 5, basato sul fatto che questa sotto-popolazione non copre i molto giovani, i molto vecchi e quelli molto ammalati.\nPer la popolazione generale (ossia consumatori ed esseri umani attraverso l’ambiente), come procedimento standard per effetti soglia, bisogna applicare un fattore 10 come difetto di valutazione. Questo fattore è assunto come sufficiente per proteggere la maggior parte della popolazione. Per i bambini può essere preso in considerazione un più alto fattore di valutazione intraspecie.\n"]
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[null,"Default assessment factors for exposure duration:                                                                                                                                                                                                                                                                                                                                                  \nIf an adequate chronic toxicity study is available, this is the preferred starting point, and no assessment factor for duration extrapolation is required 1\nOtherwise the following assessment factors are applied:\nsub-acute to chronic:  6                                                                                                                                                          \nsub-acute to sub-chronic: 3                                                                                                                                      \nsub-chronic to chronic: 2\n                                                                                                                                                                                     \nExplanation: \nAn assessment factor must be considered when assessing different exposure durations for the population and scenario under consideration: 1. in general, the experimental NOAEL will decrease with increasing exposure duration (e.g. from 28 days to 90 days) and, 2. other or more serious adverse effects may appear with increasing exposure times.\n\nThese default factors should be used for systemic effects and, in the case of toxicity testing by inhalation, for local tissue damage in the respiratory tract. ","Standard Extrapolationsfaktor für die Expositionsdauer:                                                                                                                                                                                                                                                                                                                                                  \nSofern eine geeignete chronische Toxizitätsstudie vorliegt, ist diese der bevorzugte Ausgangspunkt, und es ist kein Extrapolationsfaktor für die Expositionsdauer erforderlich: 1                                                                                                                           \nAndererseits sollten die folgenden Standard-Extrapolationsfaktoren verwendet werden:                                                                                                                                                 subakut zu chronisch:  6                                                                                                                                                          \nsubakut zu subchronisch: 3                                                                                                                                                                               subchronisch zu chronisch: 2\n                                                                                                                                                                                     \nErklärung: \nUnterschiede in der Dauer der Exposition im Experiment und bei der Bevölkerung sind unter Beachtung folgender Punkte zu berücksichtigen: 1. Im Allgemeinen sinkt der NOAEL im Experiment mit zunehmender Dauer der Expositionszeit, und 2. Können bei zunehmender Expositionszeit andere, gravierendere adverse Wirkungen auftreten.   \n\nDiese Standard-Faktoren sollten für systemische Wirkungen verwendet werden, und bei Prüfung der Inhalationstoxizität, für lokale Gewebeschäden im Respirationstrakt. ","Facteurs d’évaluation par défaut pour la durée d’exposition :\nSi une étude de toxicité chronique appropriée est disponible, elle constitue le point de départ privilégié et aucun facteur d’évaluation n’est requis pour l’extrapolation de la durée : 1\nDans le cas contraire, les facteurs d’évaluation suivants sont appliqués :\nsubaiguë à chronique : 6\nsubaiguë à subchronique : 3\nsubchronique à chronique : 2\n \nExplication :\nUn facteur d’évaluation doit être pris en compte lorsque des différences au niveau de la durée d’exposition pour la population et le scénario considérés sont évaluées : 1. En général, la NOAEL expérimentale diminue au fur et à mesure que la durée d’exposition augmente (par ex. de 28 jours à 90 jours) et 2. D’autres effets nocifs ou des effets plus graves peuvent survenir au fur et à mesure que les temps d’exposition augmentent. Par conséquent, le DNEL le plus modéré pour la toxicité par administration répétée est établi pour l’exposition chronique.\nCes facteurs par défaut doivent être utilisés pour les effets systémiques et, en cas d’essais de toxicité par inhalation, pour les lésions tissulaires locales dans les voies respiratoires.\n","Fattori standard di valutazione per durata di esposizione:\nSe è disponibile un adeguato studio di tossicità cronica, questo è il punto di partenza preferito e non è necessario alcun fattore di valutazione per la durata dell’estrapolazione: 1\nAltrimenti, vengono applicati i seguenti fattori di valutazione:\nda subacuto a cronico: 6\nda subacuto a subcronico: 3\nda subcronico a cronico: 2\n\nSpiegazione:\nÈ necessario considerare un fattore di valutazione quando si valutano le differenze nella durata di esposizione della popolazione e lo scenario preso in considerazione: 1. In generale, il NOAEL sperimentale diminuirà con la durata d’incremento dell’esposizione (per es. da 28 giorni a 90 giorni) e 2. Altri o più seri effetti contrari possono comparire con l’aumento dei tempi di esposizione. Come conseguenza, il DNEL più conservativo per tossicità a dosi ripetute è ricavato per esposizione cronica.\nQuesti fattori standard dovrebbero essere usati per effetti sistemici e, in caso di tossicità testata per inalazione, per danno tissutale locale, nel tratto respiratorio.\n"]
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[null,"Default assessment factors for dose-response relationship:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                \ndose descriptor is a NOAEL (step 1): 1                                                                                                                                                               dose descriptor is a LOAEL (step 1): 3 (as minimum/majority of cases) to 10 (as maximum/minority of cases).\n\nExplanations: \nFor dose-response relationship, consideration should be given to the uncertainties in the dose descriptor (e.g. NOAEL, LOAEL) as a surrogate for the true No-Adverse-Effect-Level (NAEL), as well as to the extrapolation of the LOAEL to the NAEL. The size of an assessment factor should take into account the dose spacing in the experiment, the shape and slope of the dose-response curve, and the extent and severity of the effect seen at the LOAEL.                                                                                                                                                                                                  ","Standard Sicherheitsfaktor für die Dosis-Wirkungs-Beziehung                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                \nNOAEL als Dosisdeskriptor (Schritt 1): 1                                                                                                                                                               LOAEL als Dosisdeskriptor (Schritt 1): 3 (Minimumfaktor/Mehrheit der Fälle) bis 10 (Maximalfaktor/In wenigen Fällen).\n                                                                                                                                                                                     \nErklärung:\nHinsichtlich der Dosis-Wirkungs-Beziehung sollten die Unsicherheiten in den Dosisdeskriptoren (NOAEL, LOAEL) als Stellvertreter für den wahren NAEL (No Adverse Effect Level) und der Extrapolation vom LOAEL auf den NAEL (wenn nur ein LOAEL vorliegt oder dieser als besser geeigneter Startpunkt angesehen wird) betrachtet werden. Die Höhe des Extrapolationsfaktors sollte die Abstände der Dosishöhen im Experiment (in heutigen Studien im Allgemeinen 2 – 4fach) sowie Verlauf und Steigung der Dosis-Wirkungs-Kurve berücksichtigen, ausserdem Ausmass und Schwere der Wirkung beim LOAEL.                                                                                                                                                           ","Facteurs d’évaluation par défaut pour la relation dose-effet :\nLe descripteur de dose est une NOAEL (étape 1) : 1\nLe descripteur de dose est une LOAEL (étape 1) : 3 (en tant que minimum, majorité des cas) à 10 (en tant que maximum, minorité des cas).\n\nExplications :\nPour la relation dose-effet, il convient de tenir compte des incertitudes au niveau du descripteur de dose (par ex. NOAEL, LOAEL) en tant que substitut pour la véritable dose sans effet toxique (NAEL), ainsi que pour l’extrapolation de la LOAEL à la NAEL. L’importance d’un facteur d’évaluation doit tenir compte de l’espacement des doses dans le cadre de l’expérience, de la forme et de la pente de la courbe dose-effet, et de l’étendue et de la gravité de l’effet observé pour la LOAEL.\n","Fattori standard di valutazione per la relazione di risposta alla dose:\nIl descrittore della dose è un NOAEL (fase 1): 1\nIl descrittore della dose è un LOAEL (fase 1): da 3 (come minoranza/maggioranza dei casi) a 10 (come maggioranza/minoranza dei casi).\n\nSpiegazioni:\nPer la relazione dose-risposta, bisogna tener conto delle incertezze nel descrittore della dose (per es. NOAEL, LOAEL) come un surrogato per il vero livello di effetto non contrario (NAEL), così come anche per l’estrapolazione del LOAEL e del NAEL. La dimensione di un fattore di valutazione dovrebbe tener conto dell’intervallo di dosaggio nell’esperimento, della forma e della pendenza della curva di risposta alla dose nonché dell’estensione e della severità dell’effetto visto al LOAEL.\n"]
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[null,"Default assessment factors for the quality of the whole database:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          \ndefault assessment factor to be applied for good/standard quality of the database: 1.\n\nExplanations: \nAn assessment factor on the quality of the whole database should, if justified, be applied to compensate for the potential remaining uncertainties in the derived DNEL. The default assessment factor should take into account completeness, consistency and the standard information requirements. A larger database assessment factor should, where relevant, be applied and justified on a case-by-case basis.          ","Standard-Sicherheitsfaktor für die Qualität der gesamten Datengrundlage:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          \nStandard-Sicherheitsfaktor bei guter/Standardqualität der Datenbasis:  1.                                                                                                                                                              \n                                                                                                                                                                               \nErklärung: \nEin Extrapolationsfaktor für die Qualität der gesamten Datengrundlage sollte im begründeten Fall angewendet werden, um mögliche verbleibende Unsicherheiten des abgeleiteten DNEL auszugleichen. Der Standard-Sicherheitsfaktor, der bei guter/Standardqualität der Datenbasis unter Berücksichtigung von Vollständigkeit, Konsistenz und Standardanforderungen anzusetzen ist, beträgt 1. Ein höherer Faktor sollte, wenn erforderlich, angesetzt werden und in einer Einzelfallbetrachtung begründet werden.      ","Facteurs d’évaluation par défaut pour la qualité de l’ensemble de la base de données :\nFacteur d’évaluation par défaut à appliquer pour la bonne qualité/qualité standard de la base de données : 1.\n\nExplications :\nUn facteur d’évaluation de la qualité de l’ensemble de la base de données doit, si cela est justifié, être appliqué pour compenser les éventuelles incertitudes restantes dans le DNEL établi. Le facteur d’évaluation par défaut doit tenir compte de l’intégralité, de la cohérence et des exigences standards en matière d’informations. Un facteur d’évaluation de bases de données plus importantes doit être appliqué, le cas échéant, et justifié au cas par cas.\n","Fattori standard di valutazione per la qualità dell’intero database:\nFattori standard di valutazione da applicare per una qualità buona/standard del database: 1\n\nSpiegazioni:\nUn fattore di valutazione relativo alla qualità di tutto il database dovrebbe, se giustificato, essere applicato per compensare le potenziali incertezze residue nel DNEL ricavato. Il fattore standard di valutazione dovrebbe tenere conto dei requisiti di completezza, di coerenza e dell’informazione standard. Un fattore di valutazione più ampio, dovrebbe, se rilevante, essere applicato e giustificato sulla base di ogni singolo caso.\n"]
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[null,"DNEL calculation procedure:\nPreferably, the value for each individual assessment factor (steps 2 & 3) in the tool is based on substance-specific information. In practice this approach has limitations (data are often scarce, e.g. on toxicokinetics and toxicodynamics) and, therefore, default assessment factors are most often required. The default factors that are implemented in the tool are explained in the information boxes in steps 2 & 3 of this tool and in more detail in the ECHA guidance document R.8.\n\nUse the comment box to (briefly) explain and justify as clearly as possible each deviation from the default process (e.g. by using substance-specific data), including any assessment factor values chosen. A link or reference can also be given, e.g. to the chemical safety report (CSR) or studies where the deviation from the default approach is explained in more detail. \n\nPlease note that the comment box is limited to 1400 characters. Detailed descriptions should be given in the CSR.\n\n\n","Erklärung und Rechtfertigung bei einer Abweichung vom Standardverfahren:\nIm Kommentarfeld soll jede Abweichung vom Standardverfahren (z.B. durch stoffspezifische Daten), einschliesslich der Wahl für einen bestimmten Wert für einen Extrapolations- oder Sicherheitsfaktor, kurz erläutert und so transparent wie möglich begründet werden. Es kann auch ein Link oder eine Referenz angegeben werden, beispielsweise auf den Stoffsicherheitsbericht (CSR) oder auf die einschlägigen Publikationen/Literatur/Studien, in denen die Abweichung von der Standardvorgehensweise in mehr Details erläutert wird. Die Standard-Faktoren, die im Tool implementiert sind, werden in den Informationskästen in Schritt 2 und 3 dieses Tools und in mehr Details in der ECHA (2012) erläutert.\n\nBitte beachten Sie, dass das Kommentarfeld nur 1400 Zeichen unterstützt. Die detaillierte Beschreibung sollte im CSR erfolgen.","Procédure de calcul de DNEL :\nLa valeur pour chaque facteur d’évaluation individuel (étapes 2 & 3) dans l’outil est basée de préférence sur des informations spécifiques à la substance. Dans la pratique, cette approche a des limites (les données sont souvent rares, par ex. en toxicocinétique et toxicodynamique) et par conséquent, des facteurs d’évaluation par défaut doivent être utilisés le plus souvent. Les facteurs par défaut utilisés dans l’outil sont expliqués dans les cadres d’information aux étapes 2 & 3 de cet outil et plus en détail dans le guide R.8 de l’ECHA.\n\nDans la zone de commentaire, tout écart par rapport à la procédure par défaut (par ex. en utilisant des données spécifiques à une substance), y compris tout choix d’une valeur de facteur d’évaluation, doit être (brièvement) expliqué et justifié de manière aussi transparente que possible. Il est également possible par ex. de fournir un lien ou de faire une référence au rapport sur la sécurité chimique (RSC) ou à des études où l’écart par rapport à l’approche par défaut est expliqué plus en détail.\n\nVeuillez noter que les commentaires ne doivent pas dépasser 1400 caractères. La description détaillée doit être fournie dans le RSC.\n\n","Procedimento per il calcolo DNEL:\nPreferibilmente, il valore per ciascun singolo fattore di valutazione (fase 2&3) nell’applicazione è basato sull’informazione specifica alla sostanza. In pratica, questo approccio ha dei limiti (i dati sono spesso scarsi, per es. sulla tossicocinetica e sulla tossicodinamica) e, perciò, il più delle volte, è necessario ricorrere ai fattori standard di valutazione. I fattori standard che sono attuati nell’applicazione sono spiegati nei riquadri informativi nella fase 2&3 di questa applicazione e con maggiori dettagli nella Guida ECHA R.8.\n\nNel riquadro di commento ogni deviazione dal processo di difetto (per es. usando dati specifici alla sostanza), compresa qualunque scelta per un valore del fattore di valutazione, dovrebbe essere (brevemente) spiegato e giustificato con la massima trasparenza. Inoltre, si può aggiungere un collegamento o una referenza per es. al rapporto di sicurezza chimica (CSR) o a studi che spiegano nei dettagli la deviazione dall’approccio standard.\nImportante: il riquadro per il commento supporta solo 1400 caratteri. La descrizione dettagliata andrebbe inserita nel CSR.\n"]
[]
[null,"How to calculate the DNEL:\n1. Please press the «Run DNEL tool» button to calculate the DNEL. The calculated DNEL value will be presented in the table below (yellow cell).\n2. Please press the «Delete DNEL values» button to delete all DNEL values and the overall assessment factor.\n3. Please press the «See DNEL results» button to show all relevant factors, parameters and formulae that were used to derive the DNEL.\n4. Press the «Add To Scenarios» button to add the DNEL scenario in the Scenario spreadsheet, which allows you to print all added scenarios in a PDF file.\n\nThe DNEL is calculated by dividing the starting point corrected N(L)OAEL(C) (step 2) by the overall assessment factor (AF) (step 3):\nDNEL = Starting point corrected N(L)OAEL(C) / Overall AF\n\nThe overall AF is calculated as:\nOverall AF = AF(Interspecies) x AF(Intraspecies) x AF(Exposure duration) x AF(Dose-response) x AF(Database quality)\n\nFor more information on individual AFs, see the information boxes in step 3 of the tool or the ECHA guidance document R.8.\n","Der DNEL wird wie folgt berechnet:\n1. Klicken Sie bitte auf die Schaltfläche «Run DNEL Tool», um den DNEL zu berechnen. Die berechneten DNELs werden in der Tabelle unten (mit einer gelben Farbe markiert) eingetragen.\n2. Klicken Sie bitte auf die Schaltfläche «Delete DNEL values», um sämtliche DNELs und den totalen Assessmentfaktor in der Tabelle zu löschen.\n3. Klicken Sie bitte auf die Schaltfläche «See DNEL results» um alle relevanten Parameter, Faktoren und Formeln für die Berechnung des DNELs anzuzeigen.\n4. Klicken Sie bitte auf die Schaltfläche «Add To Scenarios», um das berechnete DNEL-Szenario ins Arbeitsblatt «Scenarios» zu übertragen. Die berechneten DNEL Szenarien können dann als pdf-File gedruckt werden.\n\nDer DNEL wird berechnet, indem der startpunkt-korrigierte N(L)OAEL(C) (Schritt 2) durch den totalen Assessmentfaktor (Totaler AF) geteilt wird (Schritt 3):\nDNEL = startpunkt-korrigierter N(L)OAEL(C) / Totaler AF\n\nDer totale AF wird folgendermassen berechnet:\nTotaler AF = AF(Interspezies) x AF(Intraspezies) x AF(Expositionsdauer) x AF(Dosis-Wirkungs-Beziehung) x AF(Qualität der Datengrundalge)\n\nFür mehr Informationen zu den einzelnen AF konsultieren Sie bitte die Informationsboxen im Schritt 3 des Tools oder die ECHA (2012).\n","Comment calculer le DNEL :\n1. Appuyez sur le bouton « Run DNEL tool » (lancer l’outil DNEL) pour calculer le DNEL. La valeur DNEL calculée sera présentée dans le tableau ci-dessous (cellule jaune).\n2. Pour supprimer toutes les valeurs DNEL et le facteur d’évaluation global, appuyez sur le bouton « Delete DNEL valeurs » (supprimer les valeurs DNEL).\n3. Appuyez sur le bouton « See DNEL results » (voir les résultats DNEL) pour afficher l’ensemble des facteurs pertinents utilisés pour établir le DNEL.\n4. Appuyez sur le bouton « Add To Scenarios » (ajouter aux scénarios) pour ajouter le scénario DNEL à la feuille Scénario afin d’imprimer tous les scénarios ajoutés dans un fichier pdf.\n\nMéthode de calcul de DNEL :\nLe DNEL se calcule en divisant le point de départ corrigé N(L)OAEL(C) (étape 2) par le facteur d’évaluation global (AF) (étape 3) :\nDNEL = point de départ corrigé N(L)OAEL(C) / AF global\n\nThe AF global se calcule de la manière suivante :\nAF global = AF(interspécifique) x AF(intraspécifique) x AF(durée d’exposition) x AF(conséquences dose-effet) x AF(qualité base de données)\n\nPour plus d’informations sur le AF individuel, cf. les cadres d’information à l’étape 3 de l’outil ou le guide R.8 de l’ECHA.\n","Come calcolare il DNEL:\n1. Per calcolare il DNEL, premi il tasto « Run DNEL tool ». Il valore di DNEL calcolato sarà presente nella tabella sottostante (casella gialla).\n2. Per cancellare tutti i valori DNEL e il fattore di valutazione complessivo premi il tasto « Delete DNEL values »\n3. Premi il tasto « See DNEL results » per visualizzare tutti i fattori rilevanti che sono stati usati per ricavare il DNEL.\n4. Premi il tasto « Add To Scenarios » per aggiungere lo scenario DNEL, al foglio elettronico e per riprodurre tutti gli scenari aggiunti in un documento pdf.\n\nProcedimento per il calcolo DNEL:\nIl DNEL è calcolato dividendo il punto iniziale corretto N(L)OAEL(C) (fase2) per il fattore di valutazione complessivo (AF) (fase 3):\nDNEL=Punto iniziale corretto N(L)OAEL(C)/ Complessivo AF\n\nL’AF complessivo è calcolato come:\nComplessivo AF=AF(Interspecie)x AF(Interspecie)x AF(Durata d’Esposizione)x AF(Problemi risposta dose)x AF(Qualità database)\nPer maggiori informazioni circa l’AF individuale, guarda i riquadri informativi nella fase 3 dell’applicazione oppure nella Guida ECHA, documento R.8.\n"]

{"sheet":"DNEL Results","index":5,"n_rows":1017,"n_cols":31,"rows_kept":1017,"cut":false,"hidden":true,"merged":[[44,1,57,3],[225,1,238,3],[284,1,298,3],[343,1,358,3],[104,1,118,3],[144,1,144,3],[166,1,177,3]]}
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "}]
[null,"Information on phsyical-chemical properties and toxicologidcal studies relevant for DNEL calculation",null,null,null,"worker/general population - other/reprotoxic effects - systemic & local (oral-->oral; dermal-->dermal)"]
[null,"Substance Identity",null,null,null,1]
[null,"Substance Name:",{"$f":"SubstName","v":0},null,null,"oral --> oral"]
[null,"CAS Number:",{"$f":"CASNr","v":0},null,null,"dermal-->oral"]
[null,"EC Number:",{"$f":"ECNr","v":0},null,null,"oral-->dermal"]
[null,"Physical-chemical information",null,null,null,"dermal-->dermal"]
[null,"Physical state of the substance/product",{"$f":"IF(PhysicalState=\"Please select:\",\"\", PhysicalState)","v":""}]
[null,"Density",{"$f":"Density","v":0},{"$f":"IF(Density=\"\",\"\",\"kg/m3\")","v":""}]
[null,"Pure vapour pressure",{"$f":"PureVapourPressure","v":0},{"$f":"IF(PureVapourPressure=\"\",\"\",\"Pa\")","v":""}]
[null,"Molar fraction",{"$f":"MoleFraction","v":0}]
[null,"Molar mass",{"$f":"MolarMass","v":0},{"$f":"IF(MolarMass=\"\",\"\",\"mg/mol\")","v":""}]
[null,"Log Kow",{"$f":"LogKow","v":0}]
[null,"Study information"]
[null,"Leading health effect",{"$f":"LeadingHealthEffect","v":0}]
[null,"Study guideline",{"$f":"StudyGuideline","v":0}]
[null,"Study duration",{"$f":"StudyDuration","v":0},{"$f":"IF(StudyDuration=\"\",\"\",\"days\")","v":""}]
[null,"Species",{"$f":"Species","v":0}]
[null,"Number of animals in the study",{"$f":"NumerOfAnimal","v":0}]
[null,"Administration route",{"$f":"rngAdministrationRoute","v":"Please select:"}]
[null,"Step 1: Select the relevant dose descriptor for the toxicological endpoint concerned"]
[null,"Toxicological endpoint:",{"$f":"Step2ToEndpoint","v":"Other effect - systemic"}]
[null,{"$f":"Results_StringDoseDescriptor","v":"NOAEL - oral route: "},{"$f":"Results_DoseDescriptor","v":0},{"$f":"Results_DoseDescriptorUnits","v":""}]
[null,"Step 2: Modify the relevant dose descriptor per endpoint of the correct starting point"]
[null,"Starting point correction formula:"]
[null,{"$f":"Result_StartCorrectionFormula","v":"corr inh NOAEC = oral NOAEL x 1/sRVan x Diff. exp. cond. x (ABSoral,an/ABSinh,hu) x sRVhu/wRV"}]
[null,"Relevant human expsoure route:",{"$f":"rngExposureRoute","v":"Please select:"}]
[null,{"$f":"Results_StringAbsQuotient","v":"ABSoral,an/ABSinh,hu"},{"$f":"Results_ABSQuotient","v":0.5}]
[null,"Experimental animal:",{"$f":"rngExperimentalAnimal","v":"Please select:"}]
[null,"Differences experimental/human exposure conditions",{"$f":"Results_DiffExposureConditions","v":1.4}]
[null,"Corrected dose descriptor"]
[null,{"$f":"Results_StringCorrectedDoseDescriptor","v":"corr inh NOAEC: "},{"$f":"Results_CorrectedDoseDescriptors","v":0},{"$f":"Results_CorrDoseDescriptorUnits","v":""}]
[null,"Step 3: Select assessment factors"]
[null,"Interspecies, AS",{"$f":"IF(Step3AllometricScalingFactor=0,1, Step3AllometricScalingFactor)","v":1}]
[null,"Interspecies, remaining differences",{"$f":"Step3RemainingDifferences","v":0}]
[null,"AF1: Interspecies, total",{"$f":"PRODUCT(C34:C35)","v":0}]
[null,"AF2: Intraspecies",{"$f":"Step3_IntraspeciesVariability","v":0}]
[null,"AF3: Exposure duration",{"$f":"Step3DifferencesExposureDuration","v":0}]
[null,"AF4: Dose response-relationship",{"$f":"Step3IssuesRelatedToDoseResponse","v":0}]
[null,"AF5: Quality of the whole data base",{"$f":"Step3QualityDatabase","v":0}]
[null,"Overall AF (= AF1xAF2xAF3xAF4xAF5)",{"$f":"DNELOverallAF","v":0}]
[null,"DNEL Results"]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "},{"$f":"LastDNELValue","v":1.6456140350877195},{"$f":"LastDNELUnit","v":"mg/m3"}]
[null,"Comments:"]
[null,{"$f":"DNELCommentBlock","v":0}]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
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[]
[]
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[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "}]
[null,"Information on phsyical-chemical properties and toxicologidcal studies relevant for DNEL calculation",null,null,null,"worker/general population - other/reprotoxic effects - systemic",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Results_StringDNELNomenclature,\"\"))))","v":false}]
[null,"Substance Identity",null,null,null,2,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Information on phsyical-chemical properties and toxicologidcal studies relevant for DNEL calculation",null,null,null,"worker - repeated-dose - systemic"]
[null,"Substance Name:",{"$f":"SubstName","v":0},null,null,"inh-->oral",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Substance Identity",null,null,null,1]
[null,"CAS Number:",{"$f":"CASNr","v":0},null,null,"inh-->dermal",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Substance Name:",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",SubstName,\"\"))))","v":false},null,null,"oral/dermal/inhalativ --> oral"]
[null,"EC Number:",{"$f":"ECNr","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"CAS Number:",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",CASNr,\"\"))))","v":false}]
[null,"Physical-chemical information",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"EC Number:",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",ECNr,\"\"))))","v":false}]
[null,"Physical state of the substance/product",{"$f":"IF(PhysicalState=\"Please select:\",\"\",PhysicalState)","v":""},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Physical-chemical information"]
[null,"Density",{"$f":"Density","v":0},{"$f":"IF(Density=\"\",\"\",\"kg/m3\")","v":""},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Physical state of the substance/product",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",PhysicalState,\"\"))))","v":false}]
[null,"Pure vapour pressure",{"$f":"PureVapourPressure","v":0},{"$f":"IF(PureVapourPressure=\"\",\"\",\"Pa\")","v":""},null,null,null,{"$f":"IF(rngRelevantPopulation=\"worker\", IF(rngExposureRoute=\"dermal\",SubstName,\"\"),\"\")","v":""},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Density",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Density,\"\"))))","v":false}]
[null,"Molar fraction",{"$f":"MoleFraction","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Pure vapour pressure",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",PureVapourPressure,\"\"))))","v":false}]
[null,"Molar mass",{"$f":"MolarMass","v":0},{"$f":"IF(MolarMass=\"\",\"\",\"mg/mol\")","v":""},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Molar fraction",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",MoleFraction,\"\"))))","v":false}]
[null,"Log Kow",{"$f":"LogKow","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Molar mass",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",MolarMass,\"\"))))","v":false}]
[null,"Study information",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Log Kow",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",LogKow,\"\"))))","v":false}]
[null,"Leading health effect",{"$f":"LeadingHealthEffect","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Study information"]
[null,"Study guideline",{"$f":"StudyGuideline","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Leading health effect",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",LeadingHealthEffect,\"\"))))","v":false}]
[null,"Study duration",{"$f":"StudyDuration","v":0},{"$f":"IF(StudyDuration=\"\",\"\",\"day(s)\")","v":""},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Study guideline",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",StudyGuideline,\"\"))))","v":false}]
[null,"Species",{"$f":"Species","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Study duration",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",StudyDuration,\"\"))))","v":false}]
[null,"Number of animals in the study",{"$f":"NumerOfAnimal","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Species",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Species,\"\"))))","v":false}]
[null,"Administration route",{"$f":"rngAdministrationRoute","v":"Please select:"},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Number of animals in the study",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",NumerOfAnimal,\"\"))))","v":false}]
[null,"Step 1: Select the relevant dose descriptor for the toxicological endpoint concerned",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Administration route",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",rngAdministrationRoute,\"\"))))","v":false}]
[null,"Toxicological endpoint:",{"$f":"Step2ToEndpoint","v":"Other effect - systemic"},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Step 1: Select the relevant dose descriptor for the toxicological endpoint concerned"]
[null,{"$f":"Results_StringDoseDescriptor","v":"NOAEL - oral route: "},{"$f":"Results_DoseDescriptor","v":0},{"$f":"Results_DoseDescriptorUnits","v":""},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Toxicological endpoint:",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Step2ToEndpoint,\"\"))))","v":false}]
[null,"Step 2: Modify the relevant dose descriptor per endpoint of the correct starting point"]
[null,"Starting point correction formula:",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Step 2: Modify the relevant dose descriptor per endpoint of the correct starting point"]
[null,{"$f":"Result_StartCorrectionFormula","v":"corr inh NOAEC = oral NOAEL x 1/sRVan x Diff. exp. cond. x (ABSoral,an/ABSinh,hu) x sRVhu/wRV"},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Starting point correction formula:"]
[null,"Relevant human expsoure route:",{"$f":"rngExposureRoute","v":"Please select:"},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Result_StartCorrectionFormula,\"\"))))","v":false}]
[null,{"$f":"Results_StringAbsQuotient","v":"ABSoral,an/ABSinh,hu"},{"$f":"Results_ABSQuotient","v":0.5},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Relevant human expsoure route:",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",rngExposureRoute,\"\"))))","v":false}]
[null,"Experimental animal:",{"$f":"rngExperimentalAnimal","v":"Please select:"},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Results_StringAbsQuotient,\"\"))))","v":false},{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Results_ABSQuotient,\"\"))))","v":false}]
[null,"Standard respiratory volume, animal (sRVAnimal)",{"$f":"Results_sRVAnimal","v":0.38},{"$f":"Results_sRVAnimalUnits","v":"m3/kg bw/8 h"},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Experimental animal:",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",rngExperimentalAnimal,\"\"))))","v":false}]
[null,"Differences experimental/human exposure conditions",{"$f":"Results_DiffExposureConditions","v":1.4},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Differences experimental/human exposure conditions",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Results_DiffExposureConditions,\"\"))))","v":false}]
[null,"Corrected dose descriptor",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Corrected dose descriptor"]
[null,{"$f":"Results_StringCorrectedDoseDescriptor","v":"corr inh NOAEC: "},{"$f":"Results_CorrectedDoseDescriptors","v":0},{"$f":"Results_CorrDoseDescriptorUnits","v":""},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Results_StringCorrectedDoseDescriptor,\"\"))))","v":false},{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Results_CorrectedDoseDescriptors,\"\"))))","v":false},{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Results_CorrDoseDescriptorUnits,\"\"))))","v":false}]
[null,"Step 3: Select assessment factors",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Step 3: Select assessment factors"]
[null,"Interspecies, AS",{"$f":"IF(Step3AllometricScalingFactor=0,1, Step3AllometricScalingFactor)","v":1},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Interspecies, AS",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Step3AllometricScalingFactor,\"\"))))","v":false}]
[null,"Interspecies, remaining differences",{"$f":"Step3RemainingDifferences","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Interspecies, remaining differences",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Step3RemainingDifferences,\"\"))))","v":false}]
[null,"AF1: Interspecies, total",{"$f":"PRODUCT(C94:C95)","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"AF1: Interspecies, total",{"$f":"PRODUCT(AB94:AB95)","v":0}]
[null,"AF2: Intraspecies",{"$f":"Step3_IntraspeciesVariability","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"AF2: Intraspecies",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Step3_IntraspeciesVariability,\"\"))))","v":false}]
[null,"AF3: Exposure duration",{"$f":"Step3DifferencesExposureDuration","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"AF3: Exposure duration",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Step3DifferencesExposureDuration,\"\"))))","v":false}]
[null,"AF4: Dose response-relationship",{"$f":"Step3IssuesRelatedToDoseResponse","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"AF4: Dose response-relationship",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Step3IssuesRelatedToDoseResponse,\"\"))))","v":false}]
[null,"AF5: Quality of the whole data base",{"$f":"Step3QualityDatabase","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"AF5: Quality of the whole data base",{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Step3QualityDatabase,\"\"))))","v":false}]
[null,"Overall AF (= AF1xAF2xAF3xAF4xAF5)",{"$f":"DNELOverallAF","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Overall AF (= AF1xAF2xAF3xAF4xAF5)",{"$f":"PRODUCT(AB96:AB100)","v":0}]
[null,"DNEL Results",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"DNEL Results"]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "},{"$f":"LastDNELValue","v":1.6456140350877195},{"$f":"LastDNELUnit","v":"mg/m3"},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",Results_StringDNELNomenclature,\"\"))))","v":false},{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",LastDNELValue,\"\"))))","v":false},{"$f":"IF(rngRelevantPopulation=\"worker\",IF(rngAppliedDose=\"Other effect\", IF(rngEffectType=\"Systemic effects\", IF(rngExposureRoute=\"oral\",LastDNELUnit,\"\"))))","v":false}]
[null,"Comments:",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Comments:"]
[null,{"$f":"DNELCommentBlock","v":0}]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "}]
[null,"Information on phsyical-chemical properties and toxicologidcal studies relevant for DNEL calculation",null,null,null,"worker - other/reprotoxic effects - systemic"]
[null,"Substance Identity",null,null,null,3]
[null,"Substance Name:",{"$f":"SubstName","v":0},null,null,"oral-->inh"]
[null,"CAS Number:",{"$f":"CASNr","v":0},null,null,"dermal-->inh"]
[null,"EC Number:",{"$f":"ECNr","v":0}]
[null,"Physical-chemical information"]
[null,"Physical state of the substance/product",{"$f":"IF(PhysicalState=\"Please select:\",\"\",PhysicalState)","v":""}]
[null,"Density",{"$f":"Density","v":0},{"$f":"IF(Density=\"\",\"\",\"kg/m3\")","v":""}]
[null,"Pure vapour pressure",{"$f":"PureVapourPressure","v":0},{"$f":"IF(PureVapourPressure=\"\",\"\",\"Pa\")","v":""}]
[null,"Molar fraction",{"$f":"MoleFraction","v":0}]
[null,"Molar mass",{"$f":"MolarMass","v":0},{"$f":"IF(MolarMass=\"\",\"\",\"mg/mol\")","v":""}]
[null,"Log Kow",{"$f":"LogKow","v":0}]
[null,"Study information"]
[null,"Leading health effect",{"$f":"LeadingHealthEffect","v":0}]
[null,"Study guideline",{"$f":"StudyGuideline","v":0}]
[null,"Study duration",{"$f":"StudyDuration","v":0},{"$f":"IF(StudyDuration=\"\",\"\",\"days\")","v":""}]
[null,"Species",{"$f":"Species","v":0}]
[null,"Number of animals in the study",{"$f":"NumerOfAnimal","v":0}]
[null,"Administration route",{"$f":"rngAdministrationRoute","v":"Please select:"}]
[null,"Step 1: Select the relevant dose descriptor for the toxicological endpoint concerned"]
[null,"Toxicological endpoint:",{"$f":"Step2ToEndpoint","v":"Other effect - systemic"}]
[null,{"$f":"Results_StringDoseDescriptor","v":"NOAEL - oral route: "},{"$f":"Results_DoseDescriptor","v":0},{"$f":"Results_DoseDescriptorUnits","v":""}]
[null,"Step 2: Modify the relevant dose descriptor per endpoint of the correct starting point"]
[null,"Starting point correction formula:"]
[null,{"$f":"Result_StartCorrectionFormula","v":"corr inh NOAEC = oral NOAEL x 1/sRVan x Diff. exp. cond. x (ABSoral,an/ABSinh,hu) x sRVhu/wRV"}]
[null,"Relevant human expsoure route:",{"$f":"rngExposureRoute","v":"Please select:"}]
[null,{"$f":"Results_StringAbsQuotient","v":"ABSoral,an/ABSinh,hu"},{"$f":"Results_ABSQuotient","v":0.5}]
[null,"Experimental animal:",{"$f":"rngExperimentalAnimal","v":"Please select:"}]
[null,"Standard respiratory volume, animal (sRVan)",{"$f":"Results_sRVAnimal","v":0.38},{"$f":"Results_sRVAnimalUnits","v":"m3/kg bw/8 h"}]
[null,"Standard respiratory volume, human (sRVhu)",6.7,"m3 / person "]
[null,"Worker respiratory volume (wRV)",10,"m3 / person"]
[null,"Differences experimental/human exposure conditions",{"$f":"Results_DiffExposureConditions","v":1.4}]
[null,"Corrected dose descriptor"]
[null,{"$f":"Results_StringCorrectedDoseDescriptor","v":"corr inh NOAEC: "},{"$f":"Results_CorrectedDoseDescriptors","v":0},{"$f":"Results_CorrDoseDescriptorUnits","v":""}]
[null,"Step 3: Select assessment factors"]
[null,"Interspecies, AS",{"$f":"IF(Step3AllometricScalingFactor=0,1, Step3AllometricScalingFactor)","v":1}]
[null,"Interspecies, remaining differences",{"$f":"Step3RemainingDifferences","v":0}]
[null,"AF1: Interspecies, total",{"$f":"PRODUCT(C156:C157)","v":0}]
[null,"AF2: Intraspecies",{"$f":"Step3_IntraspeciesVariability","v":0}]
[null,"AF3: Exposure duration",{"$f":"Step3DifferencesExposureDuration","v":0}]
[null,"AF4: Dose response-relationship",{"$f":"Step3IssuesRelatedToDoseResponse","v":0}]
[null,"AF5: Quality of the whole data base",{"$f":"Step3QualityDatabase","v":0}]
[null,"Overall AF (= AF1xAF2xAF3xAF4xAF5)",{"$f":"DNELOverallAF","v":0}]
[null,"DNEL Results"]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "},{"$f":"LastDNELValue","v":1.6456140350877195},{"$f":"LastDNELUnit","v":"mg/m3"}]
[null,"Comments:"]
[null,{"$f":"DNELCommentBlock","v":0}]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "}]
[null,"Information on phsyical-chemical properties and toxicologidcal studies relevant for DNEL calculation",null,null,null,"worker - other/reprotoxic effects - systemic & local"]
[null,"Substance Identity",null,null,null,4]
[null,"Substance Name:",{"$f":"SubstName","v":0},null,null,"inh-->inh"]
[null,"CAS Number:",{"$f":"CASNr","v":0}]
[null,"EC Number:",{"$f":"ECNr","v":0}]
[null,"Physical-chemical information"]
[null,"Physical state of the substance/product",{"$f":"IF(PhysicalState=\"Please select:\",\"\",PhysicalState)","v":""}]
[null,"Density",{"$f":"Density","v":0},{"$f":"IF(Density=\"\",\"\",\"kg/m3\")","v":""}]
[null,"Pure vapour pressure",{"$f":"PureVapourPressure","v":0},{"$f":"IF(PureVapourPressure=\"\",\"\",\"Pa\")","v":""}]
[null,"Molar fraction",{"$f":"MoleFraction","v":0}]
[null,"Molar mass",{"$f":"MolarMass","v":0},{"$f":"IF(MolarMass=\"\",\"\",\"mg/mol\")","v":""}]
[null,"Log Kow",{"$f":"LogKow","v":0}]
[null,"Study information"]
[null,"Leading health effect",{"$f":"LeadingHealthEffect","v":0}]
[null,"Study guideline",{"$f":"StudyGuideline","v":0}]
[null,"Study duration",{"$f":"StudyDuration","v":0},{"$f":"IF(StudyDuration=\"\",\"\",\"day(s)\")","v":""}]
[null,"Species",{"$f":"Species","v":0}]
[null,"Number of animals in the study",{"$f":"NumerOfAnimal","v":0}]
[null,"Administration route",{"$f":"rngAdministrationRoute","v":"Please select:"}]
[null,"Step 1: Select the relevant dose descriptor for the toxicological endpoint concerned"]
[null,"Toxicological endpoint:",{"$f":"Step2ToEndpoint","v":"Other effect - systemic"}]
[null,{"$f":"Results_StringDoseDescriptor","v":"NOAEL - oral route: "},{"$f":"Results_DoseDescriptor","v":0},{"$f":"Results_DoseDescriptorUnits","v":""}]
[null,"Step 2: Modify the relevant dose descriptor per endpoint of the correct starting point"]
[null,"Starting point correction formula:"]
[null,{"$f":"Result_StartCorrectionFormula","v":"corr inh NOAEC = oral NOAEL x 1/sRVan x Diff. exp. cond. x (ABSoral,an/ABSinh,hu) x sRVhu/wRV"}]
[null,"Relevant human expsoure route:",{"$f":"rngExposureRoute","v":"Please select:"}]
[null,{"$f":"Results_StringAbsQuotient","v":"ABSoral,an/ABSinh,hu"},{"$f":"Results_ABSQuotient","v":0.5}]
[null,"Experimental animal:",{"$f":"rngExperimentalAnimal","v":"Please select:"}]
[null,"Standard respiratory volume, human (sRVHuman)",6.7,"m³ / person "]
[null,"Worker respiratory volume (wRV)",10,"m³ / person"]
[null,"Differences experimental/human exposure conditions",{"$f":"Results_DiffExposureConditions","v":1.4}]
[null,"Corrected dose descriptor"]
[null,{"$f":"Results_StringCorrectedDoseDescriptor","v":"corr inh NOAEC: "},{"$f":"Results_CorrectedDoseDescriptors","v":0},{"$f":"Results_CorrDoseDescriptorUnits","v":""}]
[null,"Step 3: Select assessment factors"]
[null,"Interspecies, AS",{"$f":"IF(Step3AllometricScalingFactor=0,1, Step3AllometricScalingFactor)","v":1}]
[null,"Interspecies, remaining differences",{"$f":"Step3RemainingDifferences","v":0}]
[null,"AF1: Interspecies, total",{"$f":"PRODUCT(C215:C216)","v":0}]
[null,"AF2: Intraspecies",{"$f":"Step3_IntraspeciesVariability","v":0}]
[null,"AF3: Exposure duration",{"$f":"Step3DifferencesExposureDuration","v":0}]
[null,"AF4: Dose response-relationship",{"$f":"Step3IssuesRelatedToDoseResponse","v":0}]
[null,"AF5: Quality of the whole data base",{"$f":"Step3QualityDatabase","v":0}]
[null,"Overall AF (= AF1xAF2xAF3xAF4xAF5)",{"$f":"DNELOverallAF","v":0}]
[null,"DNEL Results"]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "},{"$f":"LastDNELValue","v":1.6456140350877195},{"$f":"LastDNELUnit","v":"mg/m3"}]
[null,"Comments:"]
[null,{"$f":"DNELCommentBlock","v":0}]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "}]
[null,"Information on phsyical-chemical properties and toxicologidcal studies relevant for DNEL calculation",null,null,null,"general population - other/reprotoxic effects - systemic"]
[null,"Substance Identity",null,null,null,5]
[null,"Substance Name:",{"$f":"SubstName","v":0},null,null,"oral-->inh"]
[null,"CAS Number:",{"$f":"CASNr","v":0},null,null,"dermal-->inh"]
[null,"EC Number:",{"$f":"ECNr","v":0}]
[null,"Physical-chemical information"]
[null,"Physical state of the substance/product",{"$f":"IF(PhysicalState=\"Please select:\",\"\",PhysicalState)","v":""}]
[null,"Density",{"$f":"Density","v":0},{"$f":"IF(Density=\"\",\"\",\"kg/m3\")","v":""}]
[null,"Pure vapour pressure",{"$f":"PureVapourPressure","v":0},{"$f":"IF(PureVapourPressure=\"\",\"\",\"Pa\")","v":""}]
[null,"Molar fraction",{"$f":"MoleFraction","v":0}]
[null,"Molar mass",{"$f":"MolarMass","v":0},{"$f":"IF(MolarMass=\"\",\"\",\"mg/mol\")","v":""}]
[null,"Log Kow",{"$f":"LogKow","v":0}]
[null,"Study information"]
[null,"Leading health effect",{"$f":"LeadingHealthEffect","v":0}]
[null,"Study guideline",{"$f":"StudyGuideline","v":0}]
[null,"Study duration",{"$f":"StudyDuration","v":0},{"$f":"IF(StudyDuration=\"\",\"\",\"day(s)\")","v":""}]
[null,"Species",{"$f":"Species","v":0}]
[null,"Number of animals in the study",{"$f":"NumerOfAnimal","v":0}]
[null,"Administration route",{"$f":"rngAdministrationRoute","v":"Please select:"}]
[null,"Step 1: Select the relevant dose descriptor for the toxicological endpoint concerned"]
[null,"Toxicological endpoint:",{"$f":"Step2ToEndpoint","v":"Other effect - systemic"}]
[null,{"$f":"Results_StringDoseDescriptor","v":"NOAEL - oral route: "},{"$f":"Results_DoseDescriptor","v":0},{"$f":"Results_DoseDescriptorUnits","v":""}]
[null,"Step 2: Modify the relevant dose descriptor per endpoint of the correct starting point"]
[null,"Starting point correction formula:"]
[null,{"$f":"Result_StartCorrectionFormula","v":"corr inh NOAEC = oral NOAEL x 1/sRVan x Diff. exp. cond. x (ABSoral,an/ABSinh,hu) x sRVhu/wRV"}]
[null,"Relevant human expsoure route:",{"$f":"rngExposureRoute","v":"Please select:"}]
[null,{"$f":"Results_StringAbsQuotient","v":"ABSoral,an/ABSinh,hu"},{"$f":"Results_ABSQuotient","v":0.5}]
[null,"Experimental animal:",{"$f":"rngExperimentalAnimal","v":"Please select:"}]
[null,"Standard respiratory volume, animal (sRVan)",{"$f":"Results_sRVAnimal","v":0.38},{"$f":"Results_sRVAnimalUnits","v":"m3/kg bw/8 h"}]
[null,"Differences experimental/human exposure conditions",{"$f":"Results_DiffExposureConditions","v":1.4}]
[null,"Corrected dose descriptor"]
[null,{"$f":"Results_StringCorrectedDoseDescriptor","v":"corr inh NOAEC: "},{"$f":"Results_CorrectedDoseDescriptors","v":0},{"$f":"Results_CorrDoseDescriptorUnits","v":""}]
[null,"Step 3: Select assessment factors"]
[null,"Interspecies, AS",{"$f":"IF(Step3AllometricScalingFactor=0,1, Step3AllometricScalingFactor)","v":1}]
[null,"Interspecies, remaining differences",{"$f":"Step3RemainingDifferences","v":0}]
[null,"AF1: Interspecies, total",{"$f":"PRODUCT(C274:C275)","v":0}]
[null,"AF2: Intraspecies",{"$f":"Step3_IntraspeciesVariability","v":0}]
[null,"AF3: Exposure duration",{"$f":"Step3DifferencesExposureDuration","v":0}]
[null,"AF4: Dose response-relationship",{"$f":"Step3IssuesRelatedToDoseResponse","v":0}]
[null,"AF5: Quality of the whole data base",{"$f":"Step3QualityDatabase","v":0}]
[null,"Overall AF (= AF1xAF2xAF3xAF4xAF5)",{"$f":"DNELOverallAF","v":0}]
[null,"DNEL Results"]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "},{"$f":"LastDNELValue","v":1.6456140350877195},{"$f":"LastDNELUnit","v":"mg/m3"}]
[null,"Comments:"]
[null,{"$f":"DNELCommentBlock","v":0}]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "}]
[null,"Information on phsyical-chemical properties and toxicologidcal studies relevant for DNEL calculation",null,null,null,"general population - other/reprotoxic effects - systemic"]
[null,"Substance Identity",null,null,null,6]
[null,"Substance Name:",{"$f":"SubstName","v":0},null,null,"inh-->inh"]
[null,"CAS Number:",{"$f":"CASNr","v":0}]
[null,"EC Number:",{"$f":"ECNr","v":0}]
[null,"Physical-chemical information"]
[null,"Physical state of the substance/product",{"$f":"IF(PhysicalState=\"Please select:\",\"\",PhysicalState)","v":""}]
[null,"Density",{"$f":"Density","v":0},{"$f":"IF(Density=\"\",\"\",\"kg/m3\")","v":""}]
[null,"Pure vapour pressure",{"$f":"PureVapourPressure","v":0},{"$f":"IF(PureVapourPressure=\"\",\"\",\"Pa\")","v":""}]
[null,"Molar fraction",{"$f":"MoleFraction","v":0}]
[null,"Molar mass",{"$f":"MolarMass","v":0},{"$f":"IF(MolarMass=\"\",\"\",\"mg/mol\")","v":""}]
[null,"Log Kow",{"$f":"LogKow","v":0}]
[null,"Study information"]
[null,"Leading health effect",{"$f":"LeadingHealthEffect","v":0}]
[null,"Study guideline",{"$f":"StudyGuideline","v":0}]
[null,"Study duration",{"$f":"StudyDuration","v":0},{"$f":"IF(StudyDuration=\"\",\"\",\"day(s)\")","v":""}]
[null,"Species",{"$f":"Species","v":0}]
[null,"Number of animals in the study",{"$f":"NumerOfAnimal","v":0}]
[null,"Administration route",{"$f":"rngAdministrationRoute","v":"Please select:"}]
[null,"Step 1: Select the relevant dose descriptor for the toxicological endpoint concerned"]
[null,"Toxicological endpoint:",{"$f":"Step2ToEndpoint","v":"Other effect - systemic"}]
[null,{"$f":"Results_StringDoseDescriptor","v":"NOAEL - oral route: "},{"$f":"Results_DoseDescriptor","v":0},{"$f":"Results_DoseDescriptorUnits","v":""}]
[null,"Step 2: Modify the relevant dose descriptor per endpoint of the correct starting point"]
[null,"Starting point correction formula:"]
[null,{"$f":"Result_StartCorrectionFormula","v":"corr inh NOAEC = oral NOAEL x 1/sRVan x Diff. exp. cond. x (ABSoral,an/ABSinh,hu) x sRVhu/wRV"}]
[null,"Relevant human expsoure route:",{"$f":"rngExposureRoute","v":"Please select:"}]
[null,{"$f":"Results_StringAbsQuotient","v":"ABSoral,an/ABSinh,hu"},{"$f":"Results_ABSQuotient","v":0.5}]
[null,"Experimental animal:",{"$f":"rngExperimentalAnimal","v":"Please select:"}]
[null,"Differences experimental/human exposure conditions",{"$f":"Results_DiffExposureConditions","v":1.4}]
[null,"Corrected dose descriptor"]
[null,{"$f":"Results_StringCorrectedDoseDescriptor","v":"corr inh NOAEC: "},{"$f":"Results_CorrectedDoseDescriptors","v":0},{"$f":"Results_CorrDoseDescriptorUnits","v":""}]
[null,"Step 3: Select assessment factors"]
[null,"Interspecies, AS",{"$f":"IF(Step3AllometricScalingFactor=0,1, Step3AllometricScalingFactor)","v":1}]
[null,"Interspecies, remaining differences",{"$f":"Step3RemainingDifferences","v":0}]
[null,"AF1: Interspecies, total",{"$f":"PRODUCT(C333:C334)","v":0}]
[null,"AF2: Intraspecies",{"$f":"Step3_IntraspeciesVariability","v":0}]
[null,"AF3: Exposure duration",{"$f":"Step3DifferencesExposureDuration","v":0}]
[null,"AF4: Dose response-relationship",{"$f":"Step3IssuesRelatedToDoseResponse","v":0}]
[null,"AF5: Quality of the whole data base",{"$f":"Step3QualityDatabase","v":0}]
[null,"Overall AF (= AF1xAF2xAF3xAF4xAF5)",{"$f":"DNELOverallAF","v":0}]
[null,"DNEL Results"]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "},{"$f":"LastDNELValue","v":1.6456140350877195},{"$f":"LastDNELUnit","v":"mg/m3"}]
[null,"Comments:"]
[null,{"$f":"DNELCommentBlock","v":0}]
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[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "}]
[null,"Information on phsyical-chemical properties and toxicologidcal studies relevant for DNEL calculation",null,null,null,"Worker Skin sensitising effects"]
[null,"Substance Identity",null,null,null,1]
[null,"Substance Name:",{"$f":"SubstName","v":0}]
[null,"CAS Number:",{"$f":"CASNr","v":0}]
[null,"EC Number:",{"$f":"ECNr","v":0}]
[null,"Physical-chemical information"]
[null,"Physical state of the substance/product",{"$f":"PhysicalState","v":"Please select:"}]
[null,"Density",{"$f":"Density","v":0}]
[null,"Pure vapour pressure",{"$f":"PureVapourPressure","v":0}]
[null,"Molar fraction",{"$f":"MoleFraction","v":0}]
[null,"Molar mass",{"$f":"MolarMass","v":0}]
[null,"Log Kow",{"$f":"LogKow","v":0}]
[null,"Study information"]
[null,"Leading health effect",{"$f":"LeadingHealthEffect","v":0}]
[null,"Study guideline",{"$f":"StudyGuideline","v":0}]
[null,"Study duration",{"$f":"StudyDuration","v":0}]
[null,"Species",{"$f":"Species","v":0}]
[null,"Number of animals in the study",{"$f":"NumerOfAnimal","v":0}]
[null,"Administration route",{"$f":"AdministrationRoute","v":0}]
[null,"Step 1: Select the relevant dose descriptor for the toxicological endpoint concerned"]
[null,"Toxicological endpoint:",{"$f":"Step2ToEndpoint","v":"Other effect - systemic"}]
[null,{"$f":"Results_StringDoseDescriptor","v":"NOAEL - oral route: "},{"$f":"Results_DoseDescriptor","v":0},{"$f":"Results_DoseDescriptorUnits","v":""}]
[null,"Step 2: Modify the relevant dose descriptor per endpoint of the correct starting point"]
[null,"Starting point correction formula:"]
[null,{"$f":"Result_StartCorrectionFormula","v":"corr inh NOAEC = oral NOAEL x 1/sRVan x Diff. exp. cond. x (ABSoral,an/ABSinh,hu) x sRVhu/wRV"}]
[null,"Relevant human expsoure route:","dermal"]
[null,"Experimental animal:","mouse"]
[null,"Corrected dose descriptor"]
[null,{"$f":"Results_StringCorrectedDoseDescriptor","v":"corr inh NOAEC: "},{"$f":"Results_CorrectedDoseDescriptors","v":0},{"$f":"Results_CorrDoseDescriptorUnits","v":""}]
[null,"Step 3: Select assessment factors"]
[null,"AF1: Interspecies, total",{"$f":"Step3RemainingDifferences","v":0}]
[null,"AF2: Intraspecies",{"$f":"PRODUCT(Step3AllometricScalingFactor,Step3RemainingDifferences)","v":0}]
[null,"AF4: Dose response-relationship",{"$f":"Step3IssuesRelatedToDoseResponse","v":0}]
[null,"AF5: Quality of the whole data base",{"$f":"Step3QualityDatabase","v":0}]
[null,"AF5: Vehicle or matrix effect",{"$f":"Step3AFMatrix","v":0}]
[null,"AF6: AF for difference exposure conditions",{"$f":"Step3SkinSensAFExpConditions","v":0}]
[null,"Overall AF (= AF1xAF2xAF3xAF4xAF5)",{"$f":"PRODUCT(C391:C396)","v":0}]
[null,"DNEL Results"]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "},{"$f":"LastDNELValue","v":1.6456140350877195},{"$f":"LastDNELUnit","v":"mg/m3"}]
[null,"Comments:"]
[]
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[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "}]
[null,"Information on phsyical-chemical properties and toxicologidcal studies relevant for DNEL calculation",null,null,null,"General population - Skin sensitising effect"]
[null,"Substance Identity",null,null,null,2]
[null,"Substance Name:",{"$f":"SubstName","v":0}]
[null,"CAS Number:",{"$f":"CASNr","v":0}]
[null,"EC Number:",{"$f":"ECNr","v":0}]
[null,"Physical-chemical information"]
[null,"Physical state of the substance/product",{"$f":"PhysicalState","v":"Please select:"}]
[null,"Density",{"$f":"Density","v":0}]
[null,"Pure vapour pressure",{"$f":"PureVapourPressure","v":0}]
[null,"Molar fraction",{"$f":"MoleFraction","v":0}]
[null,"Molar mass",{"$f":"MolarMass","v":0}]
[null,"Log Kow",{"$f":"LogKow","v":0}]
[null,"Study information"]
[null,"Leading health effect",{"$f":"LeadingHealthEffect","v":0}]
[null,"Study guideline",{"$f":"StudyGuideline","v":0}]
[null,"Study duration",{"$f":"StudyDuration","v":0}]
[null,"Species",{"$f":"Species","v":0}]
[null,"Number of animals in the study",{"$f":"NumerOfAnimal","v":0}]
[null,"Administration route",{"$f":"AdministrationRoute","v":0}]
[null,"Step 1: Select the relevant dose descriptor for the toxicological endpoint concerned"]
[null,"Toxicological endpoint:",{"$f":"Step2ToEndpoint","v":"Other effect - systemic"}]
[null,{"$f":"Results_StringDoseDescriptor","v":"NOAEL - oral route: "},{"$f":"Results_DoseDescriptor","v":0},{"$f":"Results_DoseDescriptorUnits","v":""}]
[null,"Step 2: Modify the relevant dose descriptor per endpoint of the correct starting point"]
[null,"Starting point correction formula:"]
[null,{"$f":"Result_StartCorrectionFormula","v":"corr inh NOAEC = oral NOAEL x 1/sRVan x Diff. exp. cond. x (ABSoral,an/ABSinh,hu) x sRVhu/wRV"}]
[null,"Relevant human expsoure route:","dermal"]
[null,"Experimental animal:","mouse"]
[null,"Corrected dose descriptor"]
[null,{"$f":"Results_StringCorrectedDoseDescriptor","v":"corr inh NOAEC: "},{"$f":"Results_CorrectedDoseDescriptors","v":0},{"$f":"Results_CorrDoseDescriptorUnits","v":""}]
[null,"Step 3: Select assessment factors"]
[null,"AF1: Interspecies, total",{"$f":"Step3RemainingDifferences","v":0}]
[null,"AF2: Intraspecies",{"$f":"PRODUCT(Step3AllometricScalingFactor,Step3RemainingDifferences)","v":0}]
[null,"AF4: Dose response-relationship",{"$f":"Step3IssuesRelatedToDoseResponse","v":0}]
[null,"AF5: Quality of the whole data base",{"$f":"Step3QualityDatabase","v":0}]
[null,"AF5: Vehicle or matrix effect",{"$f":"Step3AFMatrix","v":0}]
[null,"AF6: AF for difference exposure conditions",{"$f":"Step3SkinSensAFExpConditions","v":0}]
[null,"Overall AF (= AF1xAF2xAF3xAF4xAF5)",{"$f":"PRODUCT(C449:C454)","v":0}]
[null,"DNEL Results"]
[null,{"$f":"Results_StringDNELNomenclature","v":"worker-DNEL long-term for inhalation route-systemic-other effect: "},{"$f":"LastDNELValue","v":1.6456140350877195},{"$f":"LastDNELUnit","v":"mg/m3"}]
[null,"Comments:"]
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[null,null,null,null,null,null,null,null,null,null,null,null,"skin sensitisation"]
[null,null,null,null,null,null,null,null,null,null,null,null,9]

{"sheet":"Scenarios","index":6,"n_rows":29,"n_cols":6,"rows_kept":29,"cut":false,"hidden":false,"merged":[[19,5,21,6]]}
[]
[]
[]
[]
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[]
[]
[null,"SECO-DNEL Tool 1.0 - Simple European Calculator Of DNEL Values",null,{"$f":"TODAY()","v":"2015-03-19"}]
[null,"Endpoint-specific DNEL"]
[null,"Worker - long term"]
[null,"Exposure Route:","Systemic: ","Units:"]
[null,"Oral",{"$f":"IF('DNEL Calculation Animal Data'!D151=0,\"\",'DNEL Calculation Animal Data'!D151)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!E151=0,\"\",'DNEL Calculation Animal Data'!E151)","v":""}]
[null,"Dermal",{"$f":"IF('DNEL Calculation Animal Data'!D152=0,\"\",'DNEL Calculation Animal Data'!D152)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!E152=0,\"\",'DNEL Calculation Animal Data'!E152)","v":""}]
[null,"Inhalation",{"$f":"IF('DNEL Calculation Animal Data'!D153=0,\"\",'DNEL Calculation Animal Data'!D153)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!E153=0,\"\",'DNEL Calculation Animal Data'!E153)","v":""}]
[null,"Worker - long term"]
[null,"Exposure Route:","Local:","Units:"]
[null,"Oral",{"$f":"IF('DNEL Calculation Animal Data'!F151=0,\"\",'DNEL Calculation Animal Data'!F151)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!G151=0,\"\",'DNEL Calculation Animal Data'!G151)","v":""}]
[null,"Dermal",null,{"$f":"IF('DNEL Calculation Animal Data'!G152=0,\"\",'DNEL Calculation Animal Data'!G152)","v":""}]
[null,"Inhalation",{"$f":"IF('DNEL Calculation Animal Data'!F153=0,\"\",'DNEL Calculation Animal Data'!F153)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!G153=0,\"\",'DNEL Calculation Animal Data'!G153)","v":""}]
[null,"General population - long term",null,null,null,{"$f":"Scenarios_ScrollDown","v":"Scroll down to see all derived DNEL scenarios. They will be printed as a PDF-file."}]
[null,"Exposure Route:","Systemic: ","Units:"]
[null,"Oral",{"$f":"IF('DNEL Calculation Animal Data'!D156=0,\"\",'DNEL Calculation Animal Data'!D156)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!E156=0,\"\",'DNEL Calculation Animal Data'!E156)","v":""}]
[null,"Dermal",{"$f":"IF('DNEL Calculation Animal Data'!D157=0,\"\",'DNEL Calculation Animal Data'!D157)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!E157=0,\"\",'DNEL Calculation Animal Data'!E157)","v":""}]
[null,"Inhalation",{"$f":"IF('DNEL Calculation Animal Data'!D158=0,\"\",'DNEL Calculation Animal Data'!D158)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!E158=0,\"\",'DNEL Calculation Animal Data'!E158)","v":""}]
[null,"General population - long term"]
[null,"Exposure Route:","Local:","Units:"]
[null,"Oral",{"$f":"IF('DNEL Calculation Animal Data'!F156=0,\"\",'DNEL Calculation Animal Data'!F156)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!G156=0,\"\",'DNEL Calculation Animal Data'!G156)","v":""}]
[null,"Dermal",{"$f":"IF('DNEL Calculation Animal Data'!F157=0,\"\",'DNEL Calculation Animal Data'!F157)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!G157=0,\"\",'DNEL Calculation Animal Data'!G157)","v":""}]
[null,"Inhalation",{"$f":"IF('DNEL Calculation Animal Data'!F158=0,\"\",'DNEL Calculation Animal Data'!F158)","v":""},{"$f":"IF('DNEL Calculation Animal Data'!G158=0,\"\",'DNEL Calculation Animal Data'!G158)","v":""}]

{"sheet":"Language","index":7,"n_rows":175,"n_cols":6,"rows_kept":175,"cut":false,"hidden":true,"merged":[]}
[null,"Language:",1]
[null,1,2,3,4,"If you have translated the tool into your language please contact… for an official next release"]
["Please select:","English","Deutsch","Francais","Italiano"]
["Actual Text"]
[{"$f":"GetLanguageString(B5:O5,$C$1)","v":"General work-flow for DNEL calculation - threshold effects"},"General work-flow for DNEL calculation - threshold effects","Allgemeines Verfahren für die Berechnung von DNELs - Schwellenwert Effekte","Plan de travail général pour le calcul de DNEL - effets de seuil\n\n\n\n","Flusso di lavoro generale per effetti soglia del calcolo DNEL\n\n"]
["Step 1: Select the relevant dose descriptor for the endpoint concerned (e.g. NOAEL, LOAEL).","Step 1: Select the relevant dose descriptor for the endpoint concerned (e.g. NOAEL, LOAEL).","Schritt 1: Auswahl des relevanten Dosisdeskriptors für den betreffenden toxikologischen Endpunkt (z.B: NOAEL, LOAEL).","Etape 1 : Sélectionnez le descripteur de dose pertinent pour le point-limite concerné (par ex. DSENO, DMENO).","Fase 1: Seleziona la dose descrittore rilevante per il punto terminale, concernente (per es. NOAEL, LOAEL).\n"]
["Step 2: Modify, when necessary, the relevant dose descriptor per endpoint to the correct starting point.","Step 2: Modify, when necessary, the relevant dose descriptor per endpoint to the correct starting point.","Schritt 2: Modifizierung, wenn nötig, des relevanten Dosisdeskriptors pro toxikologischen Endpunkt auf den korrekten Startwert.","Etape 2 : Modifiez, le cas échéant, le descripteur de dose pertinent par point-limite au point de départ approprié.","Fase 2: Modifica, se necessario, la dose descrittore rilevante per il punto terminale, al punto iniziale corretto.\n"]
["Step 3: Apply, when necessary, assessment factors to the correct starting point.","Step 3: Apply, when necessary, assessment factors to the correct starting point.","Schritt 3: Anwendung, wenn erforderlich, von Assessmentfaktoren auf den korrekten Startwert.","Etape 3 : Appliquez, le cas échéant, des facteurs d’évaluation au point de départ approprié.\n","Fase 3: Applica, quando necessario, fattori di valutazione al punto iniziale corretto.\n"]
["Results: Endpoint-specific DNEL values.","Results: Endpoint-specific DNEL values.","Resultat: Endpunkt-spezifische DNEL-Werte.","Résultats : Valeurs DNEL spécifiques au point limite.","Risultati: Valori DNEL dello specifico punto terminale."]
["Initial details of the substance and toxicological studies  ","Initial details of the substance and toxicological studies  ","Ausgangsinformationen zum Stoff und den toxikologischen Studien ","Informations de base sur la substance et études toxicologiques","Informazioni iniziali sulla sostanza e sugli studi tossicologici"]
["The white coloured cells require you to enter a value, and the yellow coloured cells offer a selection of options from which one must be selected.","The white coloured cells require you to enter a value, and the yellow coloured cells offer a selection of options from which one must be selected.","Die weiss hinterlegten Zellen erfordern die Eingabe eines Wertes. Die gelb hinterlegten Zellen bieten eine Auswahl an Möglichkeiten, von denen jeweils eine ausgewählt werden muss.","Les cellules blanches requièrent la saisie d’une valeur et les cellules jaunes invitent à sélectionner une option parmi une série de propositions.","Le cellette di colore bianco richiedono l’inserimento di un valore mentre le cellette di colore giallo offrono una selezione di opzioni, di cui una deve essere selezionata."]
[{"$f":"GetLanguageString(B12:O12,$C$1)","v":"Select new scenario for DNEL calculation?"},"Select new scenario for DNEL calculation?","Möchten Sie ein neues Szenarion für die DNEL Berechnung wählen?","Sélectionner un nouveau scénario pour le calcul de DNEL ?","Selezionare un nuovo scenario per il calcolo DNEL?\n"]
["Please enter information on the physical-chemical properties of the substance:","Please enter information on the physical-chemical properties of the substance:","Bitte geben Sie die physikalisch-chemischen Eigenschaften zum Stoff an:","Veuillez saisir des informations sur les propriétés physiques et chimiques de la substance :","Inserisci le informazioni sulle proprietà chimico-fisiche della sostanza:"]
["Product identifier:","Product identifier:","Produktidentifikator:","Identificateur de produit","Identificatore del prodotto:"]
["Substance name","Substance name","Stoffbezeichnung","Nom de la substance","Nome della sostanza"]
["CAS-Nr.","CAS-Nr.","CAS-Nr.","No CAS","N°–CAS"]
[{"$f":"GetLanguageString(B17:O17,$C$1)","v":"EC-Nr."},"EC-Nr.","EC-Nr.","No EC","N°-CE"]
["Physical state","Physical state","Aggregatzustand","Etat physique","Stato fisico"]
["Density [kg/m3]","Density [kg/m3]","Dichte [kg/m3]","Densité [kg/m3]","Densità [kg/m3]"]
["Pure vapour pressure [Pa]","Pure vapour pressure [Pa]","Reiner Dampfdruck [Pa]","Pression de vapeur saturante  [Pa]","Pressione di vapore puro [Pa]"]
["Typical concentration [%]","Typical concentration [%]","Typische Konzentration [%]","Concentration typique [%]","Concentrazione tipica [%]"]
["Log Kow","Log Kow","Log Kow","Log Kow","Log Kow"]
["Molar mass [g/mol]","Molar mass [g/mol]","Molare Masse [g/mol]","Masse molaire [g/mol]","Massa molare [g/mol]"]
["Temperature [ºC]","Temperature [ºC]","Temperatur [ºC]","Température [ºC]","Temperatura [°C]"]
["Pressure [hPa]","Pressure [hPa]","Druck [hPa]","Pression [hPa]","Pressione [hPa]"]
["Please enter details on the leading health effect and the study guideline: ","Please enter details on the leading health effect and the study guideline: ","Bitte geben Sie die relevanten Informationen zum kritischen Effekt und zu den durchgeführten Teststudien:","Veuillez saisir des précisions sur le principal effet sur la santé et les lignes directrices :","Inserisci dettagli sull’effetto salutare principale linee e sulla guida dello studio:"]
["Leading health effects (e.g. kidney effects)","Leading health effects (e.g. kidney effects)","Kritischer Effekt (z.B. Niereneffekte)","Principaux effets sur la santé (par ex. effets sur les reins)","Principali effetti sulla salute (es. patologie renali)"]
[{"$f":"GetLanguageString(B28:O28,$C$1)","v":"Study guideline (e.g. OECD TG 413)"},"Study guideline (e.g. OECD TG 413)","Teststudie (z.B: OECD TG 413)","Lignes directrices (par ex. directive n° 413 de l’OCDE)","Direttiva di studio (es. OCSE TG 413)"]
[{"$f":"GetLanguageString(B29:O29,$C$1)","v":"Study duration (e.g. 90 days)"},"Study duration (e.g. 90 days)","Studiendauer (z.B: 90 Tagen)","Durée de l’étude (par ex. 90 jours)","Durata dello studio (per es. 90 giorni)"]
[{"$f":"GetLanguageString(B30:O30,$C$1)","v":"Species (e.g. rat)"},"Species (e.g. rat)","Spezies (z.B. Ratte)","Espèce (par ex. rat)","Specie (per es. ratto)"]
[{"$f":"GetLanguageString(B31:O31,$C$1)","v":"Number of animals per dose group"},"Number of animals per dose group","Anzahl Versuchstiere pro Dosisgruppe","Nombre d’animaux par groupe de dose","Numero di animali per gruppo dose"]
["Step 1: Please select the relevant dose descriptor for the toxicological endpoint concerned.","Step 1: Please select the relevant dose descriptor for the toxicological endpoint concerned.","Schritt 1: Auswahl des relevanten Dosisdeskriptors für den betreffenden toxikologischen Endpunkt","Etape 1 : Veuillez sélectionner le descripteur de dose pertinent pour le point-limite toxicologique concerné","Fase 1: seleziona la dose descrittore rilevante per il punto terminale tossicologico:"]
["Please select toxicological endpoint:","Please select toxicological endpoint:","Bitte wählen Sie den toxikologischen Endpunkt:","Veuillez sélectionner le point-limite toxicologique :","Seleziona il punto terminale tossicologico:"]
["Please select effect type:","Please select effect type:","Bitte wählen Sie die Art des toxikologischen Effektes:","Veuillez sélectionner le type d’effet :","Seleziona il tipo di effetto:"]
["Please select a dose descriptor:","Please select a dose descriptor:","Bitte wählen Sie einen geeigneten Dosisdeskriptor:","Veuillez sélectionner un descripteur de dose :","Seleziona un descrittore di dose:"]
["Please select an administration route:","Please select an administration route:","Bitte wählen Sie einen Verabreichungsweg:","Veuillez sélectionner une voie d’administration :","Selezione una via di somministrazione:"]
["Please enter a dose descriptor value for the relevant administration route and select the correct units:","Please enter a dose descriptor value for the relevant administration route and select the correct units:","Bitte geben Sie einen Dosisdeskriptor-Wert ein und wählen Sie eine Einheit für den relevanten Verabreichungsweg:","Veuillez entrer une valeur de descripteur de dose pour la voie d’administration pertinente et sélectionner les unités appropriées :","Inserisci un valore per il descrittore di dose per la via somministrativa rilevante e seleziona le corrette unità:"]
["Please enter the effect concentration (EC, %) :","Please enter the effect concentration (EC, %) :","Bitte geben Sie einen Wert für die Effektkonzentration (EC, %) ein :"]
["Please select if the LLNA EC3 dose descriptor shall be considered as a NOAEL or LOAEL for induction:","Please select if the LLNA EC3 dose descriptor shall be considered as a NOAEL or LOAEL for induction:","Bitte wählen Sie, ob der LLNA EC3 Dosisdeskriptor ein NOAEL oder ein NOAEL für Induktion ist:"]
["Exposure route","Exposure route","Expositionsroute","Voie d’exposition","Via di esposizione"]
[{"$f":"GetLanguageString(B41:O41,$C$1)","v":"Value"},"Value","Wert","Valeur","Valore"]
[{"$f":"GetLanguageString(B42:O42,$C$1)","v":"Units"},"Units","Einheit","Unités","Unità"]
["Oral","Oral","Oral","Voie orale\n\n\n","Orale"]
["Dermal","Dermal","Dermal","Voie cutanée","Dermale"]
["Inhalation","Inhalation","Inhalation","Inhalation","Inalazione"]
["Step 2: Please modify the relevant dose descriptor per endpoint to the correct starting point.","Step 2: Please modify the relevant dose descriptor per endpoint to the correct starting point.","Schritt 2: Modifikation des relevanten Dosisdeskriptors auf den korrekten Startwert.","Etape 2 : Veuillez modifier le descripteur de dose pertinent par point-limite du point de départ approprié","Fase 2: modifica il descrittore di dose rilevante per il punto terminale del punto di partenza corretto"]
["Please select the relevant human exposure route:","Please select the relevant human exposure route:","Bitte wählen Sie die relevante Expositionsroute für den Menschen:","Veuillez sélectionner la voie d’exposition humaine pertinente :","Seleziona la via rilevante di esposizione umana:"]
["Please select the relevant population:","Please select the relevant population:","Bitte wählen Sie die relevante Bevölkerungsgruppe:","Veuillez sélectionner la population de référence :","Seleziona la popolazione rilevante:"]
["Bioavailability ","Bioavailability ","Bioverfügbarkeit","Biodisponibilité","Biodisponibilità"]
["Please account for the bioavailability of experimental animals:","Please account for the bioavailability of experimental animals:","Bitte geben Sie einen Wert für die Bioverfügbarkeit des Versuchstieres ein:","Veuillez justifier la biodisponibilité de l’animal de laboratoire :","Giustifica la biodisponibilità dell’esperimento animale:"]
["Please account for the bioavailability of humans:","Please account for the bioavailability of humans:","Bitte geben Sie einen Wert für die Bioverfügbarkeit des Menschen ein:","Veuillez justifier la biodisponibilité de l’humain :","Giustifica la biodisponibilità dell’essere umano:"]
["Please select the experimental animal:","Please select the experimental animal:","Bitte wählen Sie das Versuchstier:","Veuillez sélectionner l’animal de laboratoire :","Seleziona l’animale sperimentale:"]
["Please set consumer exposure duration:","Please set consumer exposure duration:","Bitte geben Sie die Expositionsdauer des Verbrauchers ein:","Veuillez définir la durée d’exposition du consommateur :","Imposta la durata di esposizione del consumatore."]
["Differences experimental/human exposure conditions","Differences experimental/human exposure conditions","Unterschiede experimentelle/reale Expositionsbedingungen","Différences expérimentales/conditions d’exposition humaine","Differenze di condizioni di esposizione sperimentale/umana"]
["Please select whether the toxic effect is\n1. concentration-driven or 2. dose-dependent?","Please select whether the toxic effect is\n1. concentration-driven or 2. dose-dependent?","Ist der toxische Effekt \n1. konzentrationsabhängig oder 2. dosisabhängig?","Veuillez indiquer si l’effet toxique\n1. est induit par la concentration ou 2. dépend de la dose ?\n","«Scegli se l’effetto tossico è 1. In base alla concentrazione oppure 2. a dipendenza dalla dose?»"]
["Experimental exposure conditions:","Experimental exposure conditions:","Experimentelle Expositionsbedingungen:","Conditions d’exposition expérimentales :","Condizioni di esposizione sperimentale:"]
["hours/day","hours/day","Stunden/Tag","heures/jour","Ore/giorno"]
["days/week","days/week","Tage/Woche","jours/semaine","Giorni/settimana"]
[{"$f":"GetLanguageString(B59:O59,$C$1)","v":"Results"},"Results","Resultat","Résultats","Risultati"]
["Oral","Oral","Oral","Voie orale","Orale"]
["Dermal","Dermal","Dermal","Voie cutanée","Dermale"]
["Inhalation","Inhalation","Inhalation","Inhalation","Inalazione"]
["Exposure route","Exposure route","Expositionsroute","Voie d'exposition","Via di esposizione"]
["Value","Value","Wert","Valeur","Valore\n\n"]
["Units","Units","Einheit","Unités","Unità"]
["Step 3: Please apply assessment factors to the correct starting point","Step 3: Please apply assessment factors to the correct starting point","Schritt 3: Anwendung von Assessmentfaktoren auf den korrekten Startwert.","Etape 3 : Veuillez appliquer des facteurs d’évaluation au point de départ approprié","Fase 3: applica i fattori di valutazione al punto di partenza corretto"]
["Interspecies variability","Interspecies variability","Interspezies Variabilität","Variabilité interspécifique","Variabilità interspecie"]
["Please enter an allometric scaling factor:","Please enter an allometric scaling factor:","Bitte geben Sie einen Wert für die allometrische Skalierung ein:","Veuillez saisir un coefficient d’ajustement allométrique :","Inserisci un fattore scalare allometrico:"]
[{"$f":"GetLanguageString(B69:O69,$C$1)","v":"Please account for remaining differences in interspecies variability:"},"Please account for remaining differences in interspecies variability:","Bitte geben Sie einen Wert für die restlichen Unterschiede der Interspezies Variabilität ein:","Veuillez justifier les différences restantes dans la variabilité interspécifique :","Spiega le differenze restanti nella variabilità interspecie:"]
["Intraspecies variability","Intraspecies variability","Intraspezies Variabilität","Variabilité intraspécifique","Variabilità interspecie"]
["Please account for intraspecies differences in the target population:","Please account for intraspecies differences in the target population:","Bitte geben Sie einen Wert für die Intraspezies Variabilität der Zielbevölkerung ein:","Veuillez justifier les différences intraspécifiques dans la population-cible :","Spiega le differenze intraspecie nella popolazione target:"]
["Differences in duration of exposure","Differences in duration of exposure","Unterschiede in der Expositionsdauer","Différences dans la durée d’exposition","Differenze nella durata dell’esposizione"]
["Please account for the differences in the experimental exposure duration and the duration of exposure for the population:","Please account for the differences in the experimental exposure duration and the duration of exposure for the population:","Bitte geben Sie einen Wert ein für die Unterschiede der experimentellen Expositionsdauer und den realen Expositionsbedingungen:","Veuillez justifier les différences dans la durée d’exposition expérimentale et la durée d’exposition pour la population :","Spiega le differenze tra la durata di esposizione sperimentale e la durata di esposizione per la popolazione:"]
["Issues related to dose-response","Issues related to dose-response","Dosis-Wirkungs-Beziehung","Relation dose-effet ","Relazione dose-risposta "]
["Please enter an assessment factor to account for dose-response uncertainties:","Please enter an assessment factor to account for dose-response uncertainties:","Bitte geben Sie einen Wert ein für die Unsicherheiten in den Dosis-Wirkungs-Beziehungen:","Veuillez entrer un facteur d’évaluation pour justifier les incertitudes dose-effet :","Inserisci un fattore di valutazione per spiegare le incertezze della dose-risposta:"]
["Quality of the whole database","Quality of the whole database","Qualität der gesamten Datengrundlage","Qualité de l’ensemble de la base de données","Qualità dell’intero database"]
["Please enter an assessment factor to compensate for the potential remaining uncertainties regarding the quality of the whole database :","Please enter an assessment factor to compensate for the potential remaining uncertainties regarding the quality of the whole database :","Bitte geben Sie einen Wert ein, um die restlichen Unsicherheiten der Qualität der gesamten Datengrundlage abzuschätzen:","Veuillez entrer un facteur d’évaluation pour compenser les éventuelles incertitudes restantes dans la qualité de l’ensemble de la base de données :","Inserisci un fattore di valutazione per compensare le potenziali incertezze residue nella qualità dell’intero database:"]
["Skin sensitation specific assessment factors","Skin sensitation specific assessment factors","Spezifische Assessment Faktoren für hautsensibilisierende Effekte"]
["Please apply an assessment factor for vehicle or matrix effect, e.g. matrix with penetration enhancing properties:","Please apply an assessment factor for vehicle or matrix effect, e.g. matrix with penetration enhancing properties:"]
["Please apply an assessment factor for different exposure conditions, e.g. to account for differences in skin integrity.","Please apply an assessment factor for different exposure conditions, e.g. to account for differences in skin integrity."]
["Please explain and justify, if necessary, any deviation from the default approach (max. 1400 characters):","Please explain and justify, if necessary, any deviation from the default approach (max. 1400 characters):","Bitte erklären Sie, wenn nötig, die Abweichung zum Standardverfahren (max. 1400 Zeichen):","Veuillez expliquer et justifier, le cas échéant, l’écart par rapport à l’approche par défaut (max. 1400 caractères) :","Spiega e giustifica, se necessario, la deviazione dall’approccio standard (max. 1400 caratteri):"]
["Results: Please calculate the DNEL by clicking on the «Run DNEL Tool» button","Results: Please calculate the DNEL by clicking on the «Run DNEL Tool» button","Resultat: Bitte klicken Sie für die Berechnung des DNELs auf die Schaltfläche «Run DNEL Tool».","Résultats : Veuillez calculer le DNEL en cliquant sur le bouton « Run DNEL Tool » (lancer l’outil DNEL)","Risultati: calcola il DNEL cliccando sul tasto « Run DNEL Tool »"]
["Overall assessment factor","Overall assessment factor","Totaler Assessmentfaktor","Facteur d’évaluation global","Fattore di valutazione complessivo"]
["worker-DNEL long term","worker-DNEL long term","Arbeiter-DNEL Langzeit","DNEL travailleur long terme","Lavoratori DNEL a lungo termine"]
["Systemic ","Systemic ","Systemisch","Systémique","Sistemico"]
[{"$f":"GetLanguageString(B86:O86,$C$1)","v":"Local"},"Local","Lokal","Local","Locale"]
["general population-DNEL long term","general population-DNEL long term","Allgemeine Bevölkerung-DNEL Langzeit","DNEL population générale long terme","Popolazione generale -DNEL a lungo termine"]
["Worker - skin sensitising effect","Worker - skin sensitising effect","Arbeiter - Hautsensibilisierender Effekt"]
["General population - skin sensitising effect","General population - skin sensitising effect","Allgemeine Bevölkerung - Hautsensibilisierender Effekt"]
["Leading health effect","Leading health effect","Kritischer Effekt","Principal effet sur la santé","Principale effetto sulla salute"]
["Units","Units","Einheiten","Unités","Unità"]
["Value","Value","Wert","Valeur","Valore"]
[""]
["Please select the langauge:","Please select the langauge:","Bitte wählen Sie die Sprache:","Veuillez sélectionner la langue :","Seleziona la lingua:"]
["The European Union (EU) REACh legislation requires manufacturers and importers to calculate Derived No-Effect Levels (DNELs) for substances produced in quantities above 10 tonnes/year. ","The European Union (EU) REACh legislation requires manufacturers and importers to calculate Derived No-Effect Levels (DNELs) for substances produced in quantities above 10 tonnes/year. ","Die REACh-Verordnung der Europäischen Union (EU) verpflichtet die Hersteller und Importeure Derived No-Effect Levels (DNELs) für Stoffe zu berechnen, welche im Tonnagenband ≥ 10 Tonnen / Jahr hergestellt bzw. importiert werden.","La législation REACh de l’Union européenne (UE) exige des fabricants et des importateurs qu’ils calculent les niveaux dérivés sans effet (DNEL) pour les substances produites en quantités supérieures à 10 tonnes/an.","La legislazione REACh dell’Unione europea esige che produttori e importatori per calcolino i DNEL (derived no-effect level) per sostanze prodotte in quantità sopra le 10 tonnellate/anno."]
["REACh Annex I (1.0.1.) defines DNELs as levels of exposure to the substance above which humans should not be exposed. REACh Annex I (1.4.1.) requires the establishment of DNELs for all relevant exposure patterns, reflecting the likely routes, duration and frequency of exposure. If justified by the exposure scenarios, a single DNEL may be sufficient. However, taking into account the available information and the exposure scenarios in Section 9 of the Chemical Safety Report, it may be necessary to identify different DNELs for each relevant human population (e.g. workers, general population and, if necessary, sub-populations such as children or pregnant women) and for different routes of exposure (oral, dermal, inhalation). Please note that the REACh legislation only requires that DNELs be derived for the leading health effect of a given exposure pattern, i.e. of a specific combination of exposure duration, frequency, route and human population. The leading health effect is defined as the toxic effect that leads to the lowest DNEL for a particular exposure pattern.","REACh Annex I (1.0.1.) defines DNELs as levels of exposure to the substance above which humans should not be exposed. REACh Annex I (1.4.1.) requires the establishment of DNELs for all relevant exposure patterns, reflecting the likely routes, duration and frequency of exposure. If justified by the exposure scenarios, a single DNEL may be sufficient. However, taking into account the available information and the exposure scenarios in Section 9 of the Chemical Safety Report, it may be necessary to identify different DNELs for each relevant human population (e.g. workers, general population and, if necessary, sub-populations such as children or pregnant women) and for different routes of exposure (oral, dermal, inhalation). Please note that the REACh legislation only requires that DNELs be derived for the leading health effect of a given exposure pattern, i.e. of a specific combination of exposure duration, frequency, route and human population. The leading health effect is defined as the toxic effect that leads to the lowest DNEL for a particular exposure pattern.","REACh Anhang I (1.0.1.) definiert DNELs als abgeleitete Expositionshöhen, unterhalb deren der Stoff zu keiner Beeinträchtigung der menschlichen Gesundheit führt. REACh Anhang I (1.4.1.) verlangt die Berechnung von DNELs für alle relevanten Expositionsmuster, wobei die wahrscheinlichsten Expositionswege sowie die wahrscheinlichste Expositionsdauer und -häufigkeit berücksichtigt werden. Sollten die Expositionsszenarien dies rechtfertigen, kann ein einziger DNEL-Wert ausreichen. Unter Berücksichtigung der verfügbaren Informationen und der Expositionsszenarien in Abschnitt 9 des Stoffsicherheitsberichts könnte es jedoch erforderlich sein, verschiedene DNEL-Werte für jede relevante Bevölkerungsgruppe (Arbeitnehmende, allgemeine Bevölkerung und, falls nötig, für Bevölkerungsuntergruppen wie beispielsweise Kinder und Schwangere) und für verschiedene Expositionswege (oral, dermal, inhalativ) zu ermitteln. Beachten Sie bitte, dass die REACh-Verordnung nur einen (kritischen) DNEL für die dominierende gesundheitliche Wirkung pro Expositionsmuster verlangt, d.h. für eine bestimmte Kombination von Expositionsdauer, Häufigkeit, Pfad und exponierte Bevölkerungsgruppe. Die dominierende gesundheitliche Wirkung ist definiert als die toxische Wirkung, die zum tiefsten DNEL für ein bestimmtes Expositionsmuster führt.","L’Annexe I de REACh (1.0.1.) définit le DNEL comme étant le niveau maximal d’exposition auquel l’être humain peut être soumis à une substance. L’Annexe I de REACh (1.4.1.) exige l’établissement de DNEL pour tous les scénarios d’exposition pertinents, reflétant les voies, la durée et la fréquence probables de l’exposition. Si les scénarios d’exposition le justifient, un DNEL unique peut être suffisant. Toutefois, compte tenu des informations disponibles et des scénarios d’exposition mentionnés à la section 9 du rapport sur la sécurité chimique, il peut être nécessaire d’identifier des DNEL différents pour chaque population humaine concernée (par exemple les travailleurs, la population générale et, le cas échéant, des sous-populations comme les enfants ou les femmes enceintes) et pour différentes voies d’exposition (orale, cutanée, inhalation). Veuillez noter que la législation REACh exige uniquement l’établissement d’un DNEL pour le principal effet sur la santé d’un scénario d’exposition donné, c.-à-d. d’une combinaison spécifique entre la durée, la fréquence, la voie d’exposition et la population humaine. Le principal effet sur la santé est défini comme étant l’effet toxique qui entraîne le DNEL le plus faible pour un scénario d’exposition spécifique.","L’Allegato I REACh (1.0.1.) definisce i DNEL come livelli di esposizione alla sostanza al di sopra dei quali gli esseri umani non dovrebbero essere esposti. L’Allegato I REACh (1.4.1.) esige di stabilire DNEL per tutti i modelli di esposizione rilevanti, riflettendo le probabili vie, durata e frequenza dell’esposizione. Se giustificato dagli scenari dell’esposizione, un singolo DNEL può essere sufficiente. Comunque, tenendo conto dell’informazione disponibile e gli scenari di esposizione nella Sezione 9 del Chemical Safety Report può essere necessario identificare differenti DNEL per ogni rilevante popolazione umana (per es. lavoratori, popolazione generale e, se necessario, sotto-popolazioni quali bambini o donne gravide) e per differenti vie di esposizione (orale, dermale, inalazione). Importante: la legislazione REACh esige solamente di ricavare un DNEL per il principale effetto per la salute relativamente a un determinato modello di esposizione, ossia una specifica combinazione di durata di esposizione, frequenza, via e popolazione umana. L’effetto principale per la salute è definito come l’effetto tossico che conduce al DNEL più basso (minimo) per un particolare modello di esposizione."]
["The SECO-DNEL Tool has a modular design. Each module consists of a DNEL scenario. The DNEL scenario comprises a (derived) DNEL and a set of rules used to derive the DNEL. The adoption of these rules are to be based on a broad methodological consensus and be consistent with the rules as set out by ECHA (2012). The current version 1.0 of the SECO-DNEL tool includes the DNEL scenarios for the reproductive toxicity and all non-reprotoxic effects (local or systemic) that arise from repeated exposure to a substance for a particular time span. DNELs may be derived for both workers and the general population. In total, version 1.0 of the tool contains 18 different DNEL scenarios. For more details on the DNEL scenarios, please consult the User's Manual on the SECO-DNEL tool 1.0.\n","The SECO-DNEL Tool has a modular design. Each module consists of a DNEL scenario. The DNEL scenario comprises a (derived) DNEL and a set of rules used to derive the DNEL. The adoption of these rules are to be based on a broad methodological consensus and be consistent with the rules as set out by ECHA (2012). The current version 1.0 of the SECO-DNEL tool includes the DNEL scenarios for the reproductive toxicity and all non-reprotoxic effects (local or systemic) that arise from repeated exposure to a substance for a particular time span. DNELs may be derived for both workers and the general population. In total, version 1.0 of the tool contains 18 different DNEL scenarios. For more details on the DNEL scenarios, please consult the User's Manual on the SECO-DNEL tool 1.0.\n","Das SECO-DNEL Tool ist modular aufgebaut. Jedes Modul des Tools besteht aus einem DNEL Szenario. Dieses besteht seinerseits aus einem abgeleiteten DNEL und den Regeln nach denen er abgeleitet wurde. Die Regeln müssen auf einem breiten methodologischen Konsens abgestützt sein und den Regeln der ECHA (2012) entsprechen. Diese Version 1.0 des Tools enthält DNEL Szenarien für die Reproduktionstoxizität und andere toxischen Effekte (systemisch oder lokal) auf der Grundlage von Tier-Versuchen mit wiederholter Aufnahme. Es können DNELs sowohl für Arbeitnehmende als auch für die allgemeine Bevölkerung berechnet werden. Insgesamt unterstützt das Tool in dieser Version achtzehn verschiedene DNEL-Szenarien. Weitere Einzelheiten zu den DNEL Szenarien finden Sie im Manual zum SECO DNEL Tool.","L’outil SECO-DNEL est conçu de façon modulaire. Chaque module est constitué d’un scénario DNEL. Le scénario DNEL se compose d’un DNEL (établi) et d’une série de règles sur la base desquelles le DNEL est établi. L’adhésion à ces règles doit reposer sur un important consensus méthodologique et être cohérent avec les règles définies par l’ECHA (2012). La version 1.0 actuelle de l’outil SECO-DNEL comprend les scénarios DNEL de toxicité pour la reproduction et d’autres effets toxiques (systémiques ou locaux) basés sur des données par administration répétée dans le cadre d’études sur des animaux. Les DNEL peuvent être établis à la fois pour les travailleurs et la population générale. Au total, la version 1.0 de l’outil peut gérer 18 scénarios DNEL différents. Pour plus de renseignements sur les scénarios DNEL, veuillez consulter le manuel d’utilisation de l’outil SECO-DNEL 1.0.","L’applicazione DNEL-SECO segue una concezione modulare. Ogni modulo consiste di uno scenario DNEL. Lo scenario DNEL consiste di un DNEL (ricavato) e di una serie di regole in base alle quali si ricava il DNEL. L’adozione di queste regole presuppone un ampio consenso metodologico e coerenza con le regole definite dalla ECHA (2012). L’attuale versione 1.0 dell’applicazione DNEL-SECO include gli scenari DNEL per la tossicità riproduttiva e altri effetti tossici (sistemici o locali) che sono basati su dati di studi animali con dosi ripetute. I DNEL possono essere ricavati sia per i lavoratori sia per la popolazione generale. In totale, l’applicazione nella sua versione 1.0 supporta 18 scenari DNEL differenti. Per maggiori dettagli sugli scenari DNEL consultare il Manuale dell’Utente (User’s Manual) dell’applicazione DNEL-SECO 1.0"]
["To start the tool, please press the «Start SECO-DNEL Tool 1.0» button.","To start the tool, please press the «Start SECO-DNEL Tool 1.0» button.","Bitte klicken Sie auf die Schaltfläche «Start SECO-DNEL Tool 1.0», um das Tool zu starten. ","Pour lancer l’outil, veuillez appuyer sur le bouton « Start SECO-DNEL Tool 1.0 ».","Per avviare l’applicazione, premere il tasto «Start SECO-DNEL Tool 1.0»."]
["The methodology used in this tool follows a clear procedure:\n1. Substance-specific information should be used to derive the DNEL wherever possible.\n2. If substance-specific information is not available, the default procedure shall be applied.\nThe default procedure follows the guidance rules developed by ECHA (2012). The SECO-DNEL tool does not support default procedures from other institutions. In all cases, the user of the tool is required to explain and justify any deviations from the rules as set out by ECHA (2012). Because of its modular set-up, the existing DNEL scenarios may be reassessed and revised, or new scenarios may be added to the tool. Therefore, the tool should be regularly consulted for updates. \n\nThe SECO-DNEL Tool is provided free of charge.\n","The methodology used in this tool follows a clear procedure:\n1. Substance-specific information should be used to derive the DNEL wherever possible.\n2. If substance-specific information is not available, the default procedure shall be applied.\nThe default procedure follows the guidance rules developed by ECHA (2012). The SECO-DNEL tool does not support default procedures from other institutions. In all cases, the user of the tool is required to explain and justify any deviations from the rules as set out by ECHA (2012). Because of its modular set-up, the existing DNEL scenarios may be reassessed and revised, or new scenarios may be added to the tool. Therefore, the tool should be regularly consulted for updates. \n\nThe SECO-DNEL Tool is provided free of charge.\n","Die im Tool verwendete Methodik folgt einem klaren Verfahren:\n1. Wenn möglich, sollen stoffspezifische Daten für die Ableitung eines DNELs verwendet werden.\n2. Wenn stoffspezifische Informationen nicht verfügbar sind, wird ein Standardverfahren (Standardwerte, Standardfaktoren) angeboten.\nDas Standardverfahren folgt den von der ECHA (2012) entwickelten Regeln. NEL Tool unterstützt keine Standardverfahren, die von anderen Institutionen entwickelt wurden. In jedem Fall soll der Benutzer des Tools die Abweichung von diesen Regeln rechtfertigen.  In jedem Fall soll der Benutzer des Tools eine Abweichung von diesen Regeln rechtfertigen.  Durch den modularen Aufbau des Tools, können die bestehenden DNEL Szenarien jederzeit neu bewertet und überarbeitet werden oder neue Szenarien in das Tool implementiert werden. Daher sollte das Tool regelmässig nach Updates konsultiert werden.\n\nDas SECO-DNEL Tool kann kostenlos heruntergeladen und verwendet werden.","La méthodologie utilisée dans cet outil est basée sur une procédure claire :\n1. Dans la mesure du possible, l’établissement d’un DNEL nécessite des informations spécifiques à la substance.\n2. En l’absence d’informations spécifiques à la substance, une procédure par défaut sera appliquée.\nLa procédure par défaut suit les lignes directrices élaborées par l’ECHA (2012). Dans tous les cas, l’utilisateur de l’outil est tenu d’expliquer et de justifier l’écart par rapport aux règles définies par l’ECHA (2012). L’outil SECO-DNEL n’accepte aucune autre procédure par défaut d’autres institutions. En raison de sa conception modulaire, les scénarios DNEL existants peuvent être réévalués et révisés ou de nouveaux scénarios peuvent être mis en œuvre dans l’outil. Par conséquent, l’outil doit être consulté régulièrement pour des mises à jour.\n\nL’outil SECO-DNEL est mis à disposition gratuitement.","La metodologia usata in questa applicazione segue una procedura chiara:\n1. Se possibile, l’informazione specifica alla sostanza dovrebbe essere usata per ricavare un DNEL.\n2. Se le informazioni specifiche alla sostanza non sono disponibili, una procedura standard deve essere applicata.\nLa procedura standard segue le regole guida sviluppate dall’ECHA(2012). In ogni caso, l’utente dell’applicazione è obbligato a spiegare e giustificare la deviazione dalle regole come stabilito dall’ECHA (2012). L’applicazione DNEL-SECO non supporterà altre procedure standard di altre istituzioni. Per via della loro impostazione modulare, gli scenari DNEL esistenti possono essere rivalutati e riveduti e corretti oppure possono essere attuati nuovi scenari nell’applicazione. L’applicazione, pertanto, dovrebbe essere regolarmente consultato per aggiornamenti.\n\nL’applicazione DNEL-SECO è gratuito.\n"]
[""]
["Reference: ","Reference: ","Referenz: ","Références :","Referenza:"]
["Acknowledgements","Acknowledgements","Danksagung","Remerciements","Ringraziamenti "]
["We would like to thank the Federal Institute for Occupational Safety and Health (Dortmund, Germany) for technical discussions and advice on the development of the SECO-DNEL Tool and UBit Schweiz AG for their technical support.","We would like to thank the Federal Institute for Occupational Safety and Health (Dortmund, Germany) for technical discussions and advice on the development of the SECO-DNEL Tool and UBit Schweiz AG for their technical support.","Wir danken der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin (Dortmund, Deutschland) für die fachlichen Diskussionen und ihre beratende Unterstützung bei der Entwicklung des SECO-DNEL Tool und der Firma UBit Schweiz AG für die technische Beratung.","Nous remercions l’Institut fédéral pour la sécurité et la santé au travail (Dortmund, Allemagne) pour les discussions techniques et les conseils sur le développement de l’outil SECO-DNEL et UBit pour l’assistance technique.","Ringraziamo l’Istituto Federale per la Salute e la Sicurezza del Lavoro (Dortmund, Germania) per le discussioni tecniche e per i suggerimenti in merito allo sviluppo dell’applicazione DNEL-SECO e UBit per il supporto tecnico."]
["This software was downloaded from the website of the Swiss Federal Administration. All legal conditions regarding the Swiss Federal Administration apply.","This software was downloaded from the website of the Swiss Federal Administration. All legal conditions regarding the Swiss Federal Administration apply.","Diese Software wurde von der Webpage der Schweizer Bundesverwaltung heruntergeladen. Es gelten die rechtlichen Bedingungen der Schweizer Bundesverwaltung.","Ce logiciel a été téléchargé à partir du site Internet de l’Administration fédérale suisse. Les dispositions juridiques s’appliquent eu égard à l’Administration fédérale suisse.","Questo software è stato scaricato dal sito dell’Amministrazione federale svizzera. Si applicano le condizioni legali dell’Amministrazione federale svizzera."]
["Contact:","Contact:","Kontakt:","Contact :","Contatto:"]
[""]
["Starting information","Starting information","Startinformationen","Informations concernant le démarrage.","Informazione per l’avvio"]
["Scroll down to see all derived DNEL scenarios. They will be printed as a PDF-file.","Scroll down to see all derived DNEL scenarios. They will be printed as a PDF-file.","Bitte blättern Sie nach unten, um alle abgeleiteten DNEL Szenarien zu sehen. Diese werden als pdf-Datei gedruckt.","Faites défiler vers le bas pour voir l’ensemble des scénarios DNEL établis. Ils seront imprimés en format pdf.","Scorrere verso il basso per vedere tutti gli scenari DNEL derivati. Saranno stampati come documento pdf."]
["Author","Author","Autor","Auteur","Autore"]
["Section Chemicals and Occupational Health (SECO)","Section Chemicals and Occupational Health (SECO)","Ressort Chemikalien und Arbeit (SECO)","Secteur Produits chimiques et travail (SECO)","Settore Prodotti chimici e lavoro (SECO)"]
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